TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction
TMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다
Research Article
[키워드] acquisition
Activation
Antiviral
Antiviral effect
antiviral effects
ATPase
biological significance
Cell
cell surface
characterized
cleavage
coactivator
concomitant use
consequence
coronavirus
Critical
cytoplasmic
dysregulation
ectopic expression
Effect
effector
endocytic
Endosomal acidification
epithelial cells
evade
furin
furin cleavage
furin cleavage site
gene knockout
HCoV
HCoV-229E
HCoV-NL63
highly pathogenic
Host immune response
host immune responses
IFN
IFN treatment
IFNs
immune responses
Inborn errors
Infection
infections
inhibit
inhibit SARS-CoV-2
inhibited
inhibitor
innate immune response
innate immune responses
interact
interferon
interferons
ISG
ISGs
isoform
lentivirus
less
Lung epithelial cells
lysosomal protease
mechanism
MERS
MERS-CoV
NCOA7
NL63
nuclear
nuclear receptor
option
overexpression
Particle
pathway
patients with COVID-19
plasma membrane
polybasic
promote
protease
Protein
pseudotyped
Pseudotyped viruses
receptor
removal
repertoire
Research
RNA
robust
SARS-CoV-1
SARS-CoV-2
SARS-CoV-2 entry
SARS-COV-2 infection
SARS-CoV-2 spike
seasonal
severe COVID-19
spike
Spike protein
Support
the interferon
TMPRSS
TMPRSS2
TMPRSS2 protease
Trigger
vacuolar
Vesicle
Viral
viral spike protein
virus
virus
virus entry
virus infection
virus infections
viruses
[DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article