Broadly Neutralizing Antibodies to SARS-CoV-2 Provide Novel Insights Into the Neutralization of Variants and Other Human CoronavirusesSARS-CoV-2에 대한 광범위 중화 항체는 변이체 및 기타 인간 코로나바이러스 중화에 대한 새로운 통찰력 제공Article Published on 2022-06-162022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Abstract alphacoronaviruses betacoronaviruses broadly neutralizing antibodies domain fusion peptide Human human coronaviruses insight Neutralizing Neutralizing antibodies novel Other peptide Receptor binding Receptor binding domain SARS-CoV-2 stem-helix domain. [DOI] 10.3389/fcimb.2022.928279 PMC 바로가기 [Article Type] Article
Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles널리 알려진 교차 반응성 SARS-CoV-2 CD4 T 세포 에피토프는 인간 코로나바이러스 전반에 걸쳐 고도로 보존되어 있으며 일반적인 HLA 대립유전자에 의해 제시됩니다Article Published on 2022-06-142022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Affect animal coronavirus binding CD4 CD4 T cell CD4 T cells common-cold conserved Contact convalescent COVID-19 CP: Immunology CP: Microbiology cross-reactive cross-reactivity Donor donors driven by epitope explained fusion peptide Heterologous heterologous immunity highlight HLA allele homology human coronavirus human populations Infection major histocompatibility complex memory response MHC class mRNA vaccine overlapping preference Protein proximal raise recipients residue SARS-CoV-2 SARS-CoV-2 sequence seasonal coronavirus spike fusion peptide proximal region. Substitution T cell T cell epitope T cell receptor T cell receptor repertoire T cell response TCR TCR sequencing TCRs uninfected [DOI] 10.1016/j.celrep.2022.110952 PMC 바로가기 [Article Type] Article
Structural diversity of the SARS-CoV-2 Omicron spikeSARS-CoV-2 오미크론 스파이크의 구조적 다양성Article Published on 2022-06-022022-09-11 Journal: Molecular Cell [Category] COVID19(2023년), SARS, 변종, [키워드] affecting Analysis changes in communication conformational conformational change Critical cryo Cryo-electron microscopy cryo-EM structure cryo-EM structures Crystallography Delta delta variant determine domain dominant electron microscopy epitope fusion peptide immune immune evasion Impact interprotomer communication intraprotomer communication Mutation Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron spike peptide RBD Receptor-binding domain SARS-CoV-2 evolution spike Spike protein the SARS-CoV-2 Transmissibility variant vector analysis. virus transmissibility X-ray X-ray crystallography [DOI] 10.1016/j.molcel.2022.03.028 PMC 바로가기 [Article Type] Article
Circularized fluorescent nanodiscs for probing protein-lipid interactions단백질-지질 상호작용을 조사하기 위한 원형 형광 나노디스크Article Published on 2022-05-262022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] binding biochemical events fluorescent fusion peptide GFP HIV-1 intensity Interaction involved membrane neurotransmission peptides Protein Reactions Research respond robust SARS-CoV-2 Signal transduction signaling pathways synaptotagmin synuclein translational transmembrane [DOI] 10.1038/s42003-022-03443-4 PMC 바로가기 [Article Type] Article
Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus Research Published on 2022-05-022022-10-05 Journal: Nature Communications [Category] 변종, 신종인플루엔자, 치료제, [키워드] Amino acid antibody antigenic antiviral drugs binding characterized circulating conformational conserved Critical cross-neutralization dependent on determinant determine effective ENhance epitope functional fusion peptide germline gene H1N1 H3N2 IAV in vitro in vivo influenza A virus influenza A virus influenza vaccine influenza virus Lineage MOST neutralize neutralizing antibody reactivity residue selected strain virus virus [DOI] 10.1038/s41467-022-29950-w [Article Type] Research
Recombinant subunits of SARS-CoV-2 spike protein as vaccine candidates to elicit neutralizing antibodies중화 항체를 유도하기 위한 백신 후보로서의 SARS-CoV-2 스파이크 단백질의 재조합 소단위Article Published on 2022-05-012022-09-12 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 antibody anti-spike antibody antibody Antibody titer checked Combination COVID-19 COVID-19 patient Critical effective Efficiency elicit evaluated fusion peptide in silico in vitro in vivo experiments Infection injected injection Live virus long-lasting mice neutralization neutralize Neutralizing neutralizing antibody neutralizing antibody responses produced Protein Proteins RBD recombinant Recombinant protein recombinant proteins reported robust S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virus serum serum samples shown Spike protein stimulate subunit Subunit vaccine target the SARS-CoV-2 vaccination against COVID-19 Vaccine vaccine candidate Vaccine design vaccine. VNT was increased were measured were used [DOI] 10.1002/jcla.24328 PMC 바로가기 [Article Type] Article
Omicron variant (B.1.1.529) of SARS-CoV-2: understanding mutations in the genome, S-glycoprotein, and antibody-binding regionsSARS-CoV-2의 오미크론 변이체(B.1.1.529): 게놈, S-당단백질 및 항체 결합 영역의 돌연변이 이해Article Published on 2022-04-012022-09-11 Journal: GeroScience [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Ab binding region ACE2 affinity Amino acid amino acid substitution analyzed antibody antibody affinity B.1.1.529 binding D614G domain evaluated examined fusion peptide Genome H655Y Interaction K417N Mutation mutations N501Y Neutralizing antibodies neutralizing antibody New NTD omicron Omicron variant overlapping P681H peptide Region reveal S-glycoprotein. S477N Spike protein Spike proteins stability T478K variant [DOI] 10.1007/s11357-022-00532-4 PMC 바로가기 [Article Type] Article
A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients이란 환자 중 SARS CoV-2 스파이크 당단백질에서 확인된 돌연변이에 대한 포괄적인 개요Article Published on 2022-03-012022-09-11 Journal: Gene [Category] MERS, SARS, 변종, 진단, [키워드] Alpha analysis Beta Complete database Delta delta variant Delta variants disease spread dominant variant drugs expected functional consequence fusion peptide Gamma GenBank GISAID Iran membrane fusion Mutation N-terminal domain Neutralizing antibodies neutralizing antibody NTD other variants Patient performed Phylogenetic tree protein level protein levels reference sequence Region reported retrieved S glycoprotein SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences sequence spike spike glycoprotein Spike protein submitted Vaccine variables variant variants variants of concern variants of concern (VOC) variants of interest Variants of interest (VOI). VoC Wuhan [DOI] 10.1016/j.gene.2021.146113 PMC 바로가기 [Article Type] Article
Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infectionSARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.Comparative Study Published on 2022-01-242022-09-10 Journal: eLife [Category] 변종, 치료기술, 치료제, [키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type [DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study
Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion PeptideSARS-CoV-2 융합 펩티드에 대한 인간 및 고양이 코로나바이러스 교차 반응성 항체의 기능 분석Immunology Published on 2022-01-052022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, [키워드] Against Alpha alpha- analysis antibody Antigen being betacoronaviruses binding broadly neutralizing antibodies conserved coronavirus Coronavirus infection Coronaviruses COVID-19 patients cross-reactive antibody demonstrated disease elicited endemic human coronaviruses epitope exhibited Fc-mediated effector function Fc-mediated effector functions fusion fusion peptide Human human sera immunogenic Infection Kinetics N-terminal Neutralizing activity pepscan peptide Protective S2 subunit SARS-CoV-2 SARS-CoV-2 variants sera severity spike the SARS-CoV-2 therapeutic Viral viral spike [DOI] 10.3389/fimmu.2021.790415 PMC 바로가기 [Article Type] Immunology