Heterologous adenovirus-vector/messenger RNA regimen is associated with improved severe acute respiratory syndrome coronavirus 2 humoral response in liver transplant recipientsArticle Published on 2022-10-012022-11-15 Journal: Hepatology communications [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Analysis analyzed Anti-spike anti-Spike IgG Antibody Response AstraZeneca BBIBP-CorV BMI booster response ChAdOx1 Clinical data collected Combination Concentration Control coronavirus correlation different dose dose evaluate evaluated Future groups healthy volunteer Heterologous homologous humoral IgG immunized Immunoglobulin inactivated information liver LTR LTRs Messenger RNA MMF neutralizing antibody nucleocapsid protein Odds ratio positive positive serology Probability prospective cohort study R 2 receiving recipient reduced reduction regimen reported RNA SARS-CoV-2 SARS-CoV-2 anti-spike IgG Serious Adverse Event Side effects significant difference significantly significantly higher Sinopharm Vaccine vaccine dose vaccine platform [DOI] 10.1002/hep4.2034 PMC 바로가기
Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods studyArticle Published on 2022-10-012022-11-15 Journal: Health technology assessment (Winchester, England) [Category] 진단, [키워드] administration assessment carried Characteristics Consensus COVID-19 pandemic drug duration of symptom Effectiveness evaluate experiment experiments Factor Future greater Health personnel health-care highlight IMPROVE Inflammatory bowel disease influence information journal lack less library Necrosis NHS NIHR offered over Patient Patient preference patients per day predicted Prednisolone preference preferences Probability professional professionals qualitative research randomised controlled trial Randomised controlled trials recommendation Research respond risk sample sizes secondary care Selection bias severity Side effect Side effects subject surveys and questionnaires Symptoms technology therapeutic benefits Tofacitinib Treatment ulcerative ulcerative colitis ulcerative colitis. undergo website [DOI] 10.3310/RHXR5192 PMC 바로가기
Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19Article Published on 2022-09-252022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, 치료기술, [키워드] acute phase Affect Brain changes in clinical evidence clinical study cognitive Cognitive impairment Combination Complication complications of COVID-19 COVID COVID-19 COVID-19 patients Demyelination detect disorders Factor fatigue Future help impairment include Inflammation Injury Insomnia knowledge lesions Long COVID manifestation mechanism Mental mental sequelae MRI Neuroimaging neurological neurological consequences Numerous Patient physiological post-COVID syndrome. psychiatric disorder Psychological Quality of life quantification Quantitative Research role SARS-CoV-2 syndrome virus [DOI] 10.3390/ijms231911291 PMC 바로가기
Digital PCR Applications in the SARS-CoV-2/COVID-19 Era: a Roadmap for Future OutbreaksArticle Published on 2022-09-212022-11-15 Journal: Clinical microbiology reviews [Category] SARS, 치료기술, [키워드] acute respiratory syndrome Affect affecting application caused Clinical diagnosis coronavirus coronavirus disease Course COVID-19 ddPCR Detection limit Diagnosis diagnosis and monitoring Digital digital PCR effective Factor false-negative Future global public health gold standard help infected patient Infectious disease knowledge magnitude Mutation outbreak Outbreaks pandemic PCR Precision quantification reproducibility RT-dPCR RT-qPCR SARS-CoV-2 selected sensitivity shown specificity subject tested Viral load Viral load. [DOI] 10.1128/cmr.00168-21 PMC 바로가기
SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concernArticle Published on 2022-09-182022-10-06 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] absence ACE2 acute respiratory syndrome ADK antibody BA.2 BA.5 Beta BNT162b2 breadth Breakthrough infection cell line change circulating clade Clinical effect cohorts contributed convalescent convalescent sera coronavirus COVID-19 COVID-19 hospitalisation Delta development disease severity Donor donors dose foundation Future genetic difference greater humoral Humoral response IgG in vitro isolate Lineage lineages Live virus management monitoring monoclonal antibody mortality rates nafamostat nasopharyngeal sample nasopharyngeal swabs neutralisation neutralisation assay Neutralising Antibodies neutralising antibody New observation of BNT162b2 omicron Omicron BA.1 other variant pathway peak plasma potency recorded reduced reduction reduction in Research response responses SARS-CoV-2 sensitivity significantly Sotrovimab South Spread Support supported tested Testing therapeutic Therapies TMPRSS2 TMPRSS2 inhibitor TMPRSS2. Transmission utilised vaccination Vaccine variant viral lineage viral variant [DOI] 10.1016/j.ebiom.2022.104270 PMC 바로가기 [Article Type] Article
Clinical Characteristics and Implications of Bradycardia in COVID-19 Patients Treated with Remdesivir: A Single-Center Retrospective Cohort StudyArticle Published on 2022-09-012022-11-15 Journal: Clinical drug investigation [Category] SARS, 치료제, [키워드] administration age analyzed antiviral drug blockers bradycardia bradycardic cardiac complication cardiac effect cause Characteristics clinical Clinical characteristics Cohort conducted coronavirus disease COVID-19 COVID-19 patient D-dimer level elimination half-life Endotracheal intubation examined excluded Frame Future hyperlipidemia in-hospital mortality inclusion criteria initiated investigated Mortality occur outcomes Patient predictor previous study Remdesivir reported Retrospective study serum Sex significant difference significantly more statistical test treat Treatment undergo [DOI] 10.1007/s40261-022-01187-x PMC 바로가기
Impact of the COVID-19 Pandemic on Korean Adolescents’ Mental Health and Lifestyle FactorsResearch article Published on 2022-09-012022-10-05 Journal: The Journal of adolescent health : official public [Category] 진단, [키워드] Adolescent adolescents affected analyses Analysis Behavior caused changes in Cohort collected conducted coronavirus disease COVID-19 COVID-19 outbreak COVID-19 pandemic cross-sectional Depression depressive determine Effect emotional Factor Future ideation Impact Internet Korean KYRBS Lifestyle factors long-lasting mental health National pandemic Perceived stress physical activity levels Research Result Satisfaction Suicide survey thought Youth [DOI] 10.1016/j.jadohealth.2022.05.020 [Article Type] Research article
COVID-19 mRNA vaccine effectiveness against hospitalisation and death in veterans according to frailty status during the SARS-CoV-2 delta (B.1.617.2) variant surge in the USA: a retrospective cohort studyResearch article Published on 2022-09-012022-10-05 Journal: The Lancet. Healthy longevity [Category] SARS, 변종, 임상, [키워드] 95% CI Affair age Antigen assessment B.1.617.2 baseline category Cemetery center clinical COVID-19 COVID-19 vaccination COVID-19 vaccine death Department diagnosed education effective Effectiveness finding frailty funding Future hazard ratio hospitalisation information males medical condition Miami mRNA vaccine Odds ratio Older Patient populations positive Positive test preventing infection Primary outcome recruit reduced retrieved retrospective cohort study robust RT-PCR SARS-CoV-2 SARS-CoV-2 test shown Sociodemographic characteristics System tested the SARS-CoV-2 the vaccine used data vaccination Vaccine variant variant of SARS-CoV-2 veteran White people [DOI] 10.1016/S2666-7568(22)00166-0 [Article Type] Research article
Pilot study for immunoglobulin E as a prognostic biomarker in coronavirus disease 2019Article Published on 2022-09-012022-11-15 Journal: Internal medicine journal [Category] SARS, 바이오마커, 진단, [키워드] Admission age Analysis average baseline Biomarker C-reactive protein changes in clinical progression clinically Concentration coronavirus disease COVID-19 COVID-19 infection COVID-19 infections COVID-19 patient COVID-19 patients cut-off determine Disease progression enrolled eosinophil evaluate the effect ferritin Future hospitalisation hospitalised IgE immune Immunoglobulin independent predictors individual inflammatory parameter males Negative predictive value outcome pandemic parameter Patient patients pilot study Positive predictive value predisposition prognostic biomarker Prognostic factor progression required resource risk factor sensitivity serum severity significantly lower specificity to define total IgE. were measured were recorded with COVID-19 worsened worsening [DOI] 10.1111/imj.15728 PMC 바로가기
COVID-19 infection after two doses of SARS-CoV-2 mRNA vaccine in multiple sclerosis, AQP4-antibody NMOSD and MOGADObservational Study Published on 2022-09-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] Analysis anti-CD20 calculated conducted COVID-19 COVID-19 infection demographics disease disorder dose Follow-up Future help highest increased risk infected patients infected with COVID-19 Infection infection rate infection risk interferons investigated majority Mild MOGAD mRNA vaccination mRNA vaccine Multiple multiple sclerosis Neuromyelitis Neuromyelitis Optica observation oxygen supplementation Patient patients Prednisolone Prevent prospective observational study recruited required risk of COVID-19 robust SARS-CoV-2 Severe infection Singapore subsequent symptomatic therapy vaccinated individual vaccination Vaccinations vaccine. was collected were recorded [DOI] 10.1016/j.msard.2022.104003 PMC 바로가기 [Article Type] Observational Study