SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identificationArticle Published on 2022-10-252022-11-16 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Accuracy analysis approach association Blood build complex component COVID-19 severity dataset eQTL etiology explain expression Gene Expression Genetic Genome-wide association study identify IMPROVE loci low expression modeling moderate proportion provided Quantitative regulated severity Simulation study Statistical power traits transcriptome-wide transcriptomic data with COVID-19 [DOI] 10.1038/s41467-022-34016-y PMC 바로가기
HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infectionsArticle Published on 2022-10-172022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alteration Analysis antigenic Cell cells changes in co-morbidities COVID-19 COVID-19 patient COVID-19 patients decrease DNA DNA methylation dysregulation enhancer enhancer transcriptional regulation evade expression Gene Expression gene expression profile genes encoding healthy controls HLA-C Host immune evasion immune response immune system implicated Infection inhibit Intervention involved mechanism memory response Methylation modify overlap Pathogens presenting Prognosis Prognostic marker Protein respiratory infection SARS-CoV-2 shown significantly symptomatic and asymptomatic symptomatic and asymptomatic COVID-19 T-cell therapeutic target transcriptional upper airway upper airways cells. viral antigens virus [DOI] 10.3389/fimmu.2022.1011829 PMC 바로가기
A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin DArticle Published on 2022-10-142022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Apoptosis changes in Chromatin structure contribute COVID-19 COVID-19 infections disease risk drug Effect Epigenetic epigenetic modification epigenetics Evidence Gene Expression Health help highlight Host immune response Immunity immunomodulatory effect indicate individual Infection Inflammation involved mechanisms Modification modulated multifunctional outcomes pathophysiology Prevent proliferation receptor receptor function reduced regulate SARS-CoV-2 target therapeutic therapeutic drug Treatment Vaccine viral outbreak virus Vitamin D vitamin D. while [DOI] 10.3390/ijms232012292 PMC 바로가기
Amikacin-loaded niosome nanoparticles improve amikacin activity against antibiotic-resistant Klebsiella pneumoniae strainsArticle Published on 2022-10-032022-11-16 Journal: World journal of microbiology & biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Amikacin analyzed antibiotic Antibiotic-resistance Antibiotics Bacteria Bacterial infection Bacterial infections calculated Cell cholesterol Concentration Coverage cytotoxicity drug resistance drug-resistant evaluated Gene Expression highest hospitalized patients IMPROVE inhibited Klebsiella Klebsiella pneumoniae less MBC MDR mechanism mRNA expression multi-drug resistant Niosome Niosome. occur positive ranged reduced SARS-CoV-2 significantly Spread stability strain Strains Toxicity Treatment were measured [DOI] 10.1007/s11274-022-03405-2 PMC 바로가기
Quantitative Assay of SARS-CoV-2 RNA and Level of Proinflammatory Protein Gene Transcripts in Peripheral Blood Leukocytes after a Novel Coronavirus InfectionArticle Published on 2022-10-012023-07-10 Journal: Bulletin of experimental biology and medicine [Category] COVID19(2023년), [키워드] droplet digital PCR Gene Expression Inflammation Novel coronavirus infection. SARS-CoV-2 [DOI] 10.1007/s10517-022-05621-0 PMC 바로가기
Social connection and gene regulation during the COVID-19 pandemic: Divergent patterns for online and in-person interactionArticle Published on 2022-10-012022-11-15 Journal: Psychoneuroendocrinology [Category] 치료제, [키워드] absence analyzed antibody production antiviral immunity antiviral response association blood sample characterized connection conserved COVID-19 COVID-19 pandemic CTRA disease risk down-regulation Effect eudaimonia examined experience Factors female Gene Expression Health healthy Immune cell immune system Interaction Linear model loneliness measure Multiple offset Online social interaction profile proinflammatory gene quantified question reduced Regulation RNA Social genomics. social interaction transcriptional response [DOI] 10.1016/j.psyneuen.2022.105885 PMC 바로가기
Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflowArticle Published on 2022-10-012022-11-16 Journal: Functional & integrative genomics [Category] meta-analysis, [키워드] analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes. upregulated utility [DOI] 10.1007/s10142-022-00881-5 PMC 바로가기
Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesisArticle Published on 2022-10-012022-11-16 Journal: Experimental & Molecular Medicine [Category] 변종, 유전자 메커니즘, [키워드] analysis ChIP chromatin chromatin architecture classical monocytes clinical impact COVID-19 dissect element exacerbating exhibited facilitate Gene Expression gene expression signature Hematopoiesis highlight hyperinflammation IFN-γ immunological individual Inflammation inflammatory immune response Inflammatory responses interactions mechanism methylated mononuclear cells Patient Peripheral blood putative target gene Region Regulatory reported severe COVID-19 severe COVID-19 patients severity single-cell susceptibility Transcriptome with COVID-19 [DOI] 10.1038/s12276-022-00866-1 PMC 바로가기
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expressionArticle Published on 2022-09-262022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 analysis approach bioinformatics Concordance COVID-19 debatable differentially expressed gene expressed expression Gene Expression hACE2 Human immune signature Immunity immunopathology inflammatory pathway K18-hACE2 lung damage Lungs mice mouse model orthologue overlap promoter SARS-CoV-2 single copy transcriptional profile transcriptional response Treatment Viral load virus wild-type [DOI] 10.1371/journal.ppat.1010867 PMC 바로가기
Antiviral Immunoglobulins of Chicken Egg Yolk for Potential Prevention of SARS-CoV-2 InfectionArticle Published on 2022-09-262022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료제, [키워드] addition amplification analyzed anti-RBD antibody Antiviral antiviral strategy. assays Cell chicken clinical development cytokine domain Egg ELISA examined expression of SARS-CoV-2 Gene Expression golden hamster Host IgY immune immunization immunized immunoblot in vitro in vivo interval layer lung management monoclonal antibody neutralization capacity neutralized neutralizing antibody outbreak Outbreaks polyclonal Potential prevention purified qRT-PCR RBD SARS-CoV-2 SARS-COV-2 infection Syrian golden hamster target the S protein VERO-E6 Vero-E6 cell viability viral outbreak viral RBD Viral RNA virus virus variant viruses was measured yolk [DOI] 10.3390/v14102121 PMC 바로가기