Screening the hub genes and analyzing the mechanisms in discharged COVID-19 patients retesting positive through bioinformatics analysis생물정보학 분석을 통해 퇴원한 코로나19 환자 재검사에서 허브 유전자 스크리닝 및 기전 분석Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] 유전자 메커니즘, [키워드] ALKBH6 AMBRA1 Analysis analyzed ANAPC1 Apoptosis ATP1A1 ATP1A1-AS1 bioinformatics Bioinformatics analysis convalescent COVID-19 COVID-19 patient COVID-19 patients cytoHubba differentially expressed gene discharge discharged DISP1 DOCK4 down-regulated down-regulated gene enrichment analysis expression data FAM149B1 FAM241B Gene Expression Omnibus Gene ontology Genes genomes GEO healthy control hub genes IGLV1-40 immune immune response KEGG Kyoto LRRC69 management mechanism MICAL3 Microarray MIR1249 mRNA Pathogenesis Patient patients PLPPR2 positive PPI PPI network Prognosis prognostic protein-protein interaction PSMG1 R software Rab11b RAB11B-AS1 retesting positive after discharged. Ribonucleic acid risk screened Screening selected significant enrichment SNRPD1 SNRPD2 SORT1 TP53BP1 TRAV18 two group two groups up-regulated virus was performed [DOI] 10.1002/jcla.24495 PMC 바로가기 [Article Type] Article
Analysis of mechanisms of Shenhuang Granule in treating severe COVID-19 based on network pharmacology and molecular dockingResearch article Published on 2022-07-012022-10-05 Journal: Journal of integrative medicine [Category] 유전자 메커니즘, 임상, [키워드] ABCB1 acute respiratory syndrome Analysis Calcium signaling CAMP Chinese complex component coronavirus coronavirus disease COVID-19 CXCL8 Cytokine storm database DNMT1 docking effective enrichment analysis expected experiments Functional enrichment analysis Gene Expression Omnibus GEO Granule HDAC3 Helicase HSP90AA1 IFNg indicated inhibit Interaction Invasion MDM2 mechanism mechanisms mild cases MMP9 molecular docking Molecular dynamics simulation Multiple network pharmacology neuroactive objective pathway performed platform predicted protein targets Protein–protein interaction provide PTGS2 randomized clinical trial regulated Result Safe SARS-CoV-2 severe COVID-19 Shenhuang granule shown Signaling signaling pathway stability SwissTargetPrediction target therapeutic target therapeutic targets Treatment TYMS virus were used worse prognosis [DOI] 10.1016/j.joim.2022.07.005 [Article Type] Research article
Identification of critical genes and molecular pathways in COVID-19 myocarditis and constructing gene regulatory networks by bioinformatic analysis코로나19 심근염의 핵심 유전자 및 분자경로 규명 및 생물정보분석을 통한 유전자 조절 네트워크 구축Article Published on 2022-06-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] adjusted Algorithms Analysis bioinformatic analysis bioinformatics biological processe biological processes CDC20 CDK1 Cell cell cycle Compound correlation COVID-19 Critical Cytoscape dataset DEGs differentially expressed gene down-regulated genes drug drugs enrichment analysis etoposide Evidence evidence of fold Functional enrichment analyses Functional enrichment analysis Gene Expression Gene Expression Omnibus gene regulatory network Genes GEO highlighting hydrolysis identification identify in vitro indicated infected with SARS-CoV-2 Interaction KIF20A KIF2C mechanism methotrexate molecular myocarditis network analysis overlapped P-value Pathogenesis pathway Patient PBK performed Perspective pluripotent stem cell Potential biomarker potential biomarkers PPI probe protein-protein interaction provide R software Regulatory signature target transcription factor Treatment Troglitazone turquoise module UBE2C up-regulated was used website were assessed WGCNA with COVID-19 [DOI] 10.1371/journal.pone.0269386 PMC 바로가기 [Article Type] Article
XGBoost-Based Feature Learning Method for Mining COVID-19 Novel Diagnostic MarkersCOVID-19 신규 진단 마커 마이닝을 위한 XGBoost 기반 기능 학습 방법Article Published on 2022-06-222022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] analyzed biological function Biological functions China Classifier coronavirus coronavirus disease Coronavirus pneumonia COVID-19 database demonstrated diagnostic Diagnostic biomarkers Diagnostic markers downloaded effective enrichment analyses expression profiling Gene Expression Omnibus Genes GEO Health identify involved KEGG learning machine learning marker MCC negative patients novel Novel coronavirus novel coronavirus pneumonia outbreak pathway Pathways Patient patients Pneumonia positive Principal component principal component analysis selected signaling pathway signaling pathways Spread SVM throat swab Viral viral gene expression viral transcription was used Wuhan XGBoost [DOI] 10.3389/fpubh.2022.926069 PMC 바로가기 [Article Type] Article
Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)치주염은 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 프라이밍 프로테아제인 치은 막횡단 세린 프로테아제 2(TMPRSS2)의 발현을 촉진합니다Article Published on 2022-06-012022-09-11 Journal: Journal of oral biosciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome Analysis analyzed anti-TMPRSS2 antibody cell membrane ChIP coronavirus correlation COVID-19 dataset datasets ESR1 Estrogen estrogen receptor Express expressed expression Gene Expression Gene Expression Omnibus GEO GEO dataset Gingiva Human increase increased expression investigated keratinocytes Ligand oral cavity Periodontitis priming promote promoter promoter region protease Quantitative responsible reverse transcription SARS-CoV-2 SARS-CoV-2 spike protein screened Serine Spike protein the SARS-CoV-2 tissue tissues TMPRSS2 TMPRSS2 expression transcription factor transcription factors transmembrane serine protease transmembrane serine protease 2 was performed western blot Western blot analysis [DOI] 10.1016/j.job.2022.04.004 PMC 바로가기 [Article Type] Article
Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related StrokeCOVID-19 관련 뇌졸중의 잠재적 생물학적 과정 및 주요 유전자를 식별하기 위한 가중 유전자 공동 발현 네트워크 분석Article Published on 2022-05-092022-09-11 Journal: Oxidative Medicine and Cellular Longevity [Category] 유전자 메커니즘, [키워드] Analysis Biological biological processe Cell coronavirus disease COVID-19 Critical Cytoscape Cytoscape software cytosolic database dataset datasets elevated enrichment analysis Extracellular matrix FIVE Functional enrichment analysis gene co-expression network Gene Expression Omnibus Gene ontology Genes GEO hub genes identify indicated integrin integrin signaling Interaction Intervention involved ITGA2B ITGB3 KEGG Kyoto Lineage network pathway Pathways PI3K PI3K-Akt signaling Platelet platelet activation Potential receptor Research screened stroke target was used [DOI] 10.1155/2022/4526022 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13기도 세포의 SARS-CoV-2 감염은 IL-13에 의해 영향을 받는 두 가지 확산 메커니즘인 강력한 바이러스 및 세포 방출을 유발합니다Article Published on 2022-04-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected airway airways Allergic asthma Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Asthma asthmatic cause caused Cell Cell culture cell cultures cell tropism cells ciliated cell ciliated cells coronavirus COVID-19 COVID-19 severity down-regulated gene down-regulated genes electron microscopy enzyme epithelial epithelial cells examined expression gene expression analyses Gene Expression Omnibus Genes glycoprotein HAE high risk host–virus interaction human airway human airway epithelial human airway epithelial cells IL-13 IL-13 cytokine immunohistochemistry In situ hybridization infected cells Infection interferon interleukin interleukin-13 Intracellular involved keratan sulfate Lung disease mechanism Messenger RNA Microscopy MUC5AC mucin Mucus number of infected primary human airway reduced removal Replication RNA RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shedding shielding significantly Spread sulfate susceptibility Transmission Transport TRAP treated up-regulated viral egress viral entry Viral load Viral reservoir viral spread viral titers virions viruses were infected [DOI] 10.1073/pnas.2119680119 PMC 바로가기 [Article Type] Article
New Approach for Targeted Treatment of Mild COVID-19 by Honeysuckle through Network Pharmacology Analysis네트워크 약리학 분석을 통한 인동덩굴의 경증 COVID-19 표적 치료를 위한 새로운 접근 방식Research Article Published on 2022-02-212022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] COVID19(2023년), MERS, SARS, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] Analysis Cell Chinese CIBERSORT collected complex component coronavirus disease Coronavirus disease 2019 correlated Correlation analysis COVID-19 Data quality database differentially expressed differentially expressed gene effective enrichment analysis evaluated expression expressions FIVE Gene Expression Omnibus Genes GEO hematopoietic stem cells honeysuckle Immune cell infiltration immune cells immune signaling pathways Infection infiltration ingredient MAP3K7 mechanism Medicine Mild molecular natural killer network New NK cell NK cells objective overlapping Patient pharmacokinetics pharmacological Pharmacology positive correlation predict proportion protective effect RELA Result Safe screened Seven significantly statistically significant suggested target targets TCMSP toolkit Traditional Traditional Chinese medicine Transcriptome was related [DOI] 10.1155/2022/9604456 PMC 바로가기 [Article Type] Research Article
Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma카텝신 B는 폐 선암종을 가진 코로나바이러스 질병 2019 환자를 위한 잠재적인 치료 표적입니다Article Published on 2022-02-012022-09-11 Journal: Chemico-biological interactions [Category] 바이오마커, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Atla available data Basigin bioinformatics cancers cathepsin cathepsin B cause Cell coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CTSB database determine diagnosed with COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 drug therapy explain expressed expression Gene Expression Omnibus GEO global public health Hyperinflammatory Hyperinflammatory response identify Immune cell infiltration implicated lung adenocarcinoma lung cancer lung cancer patient lung cancer patients mortality rate outcome Patient patients patients with COVID-19 positively correlated potential therapeutic target presenting Proinflammatory cytokine SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility the SARS-CoV-2 therapeutic target therapy for COVID-19 tissue upregulation [DOI] 10.1016/j.cbi.2022.109796 PMC 바로가기 [Article Type] Article
Molecular Mechanisms of Cardiac Injury Associated With Myocardial SARS-CoV-2 InfectionCardiovascular Medicine Published on 2022-01-202022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] activated acute respiratory syndrome Analysis Apoptosis Bioinformatics analysis cardiac cardiac injury caused Cell cellular coronavirus Coronavirus disease 2019 COVID-19 Cytokine activation dataset DEGs differentially expressed gene drug enrichment analysis excessive inflammatory response expression profiling functional Gene Expression Omnibus Genes Genome GEO GSEA hypoxia immune Inflammation inhibited Injury involved KEGG Kyoto myocardial injury Ontology Pathogenesis Pathway analysis patients with COVID-19 PPI Protein–protein interaction reduction response resulting RNA-Seq SARS-CoV-2 SARS-COV-2 infection Spread upregulated gene was obtained [DOI] 10.3389/fcvm.2021.643958 PMC 바로가기 [Article Type] Cardiovascular Medicine