CYP6P9-Driven Signatures of Selective Sweep of Metabolic Resistance to Pyrethroids in the Malaria Vector Anopheles funestus Reveal Contemporary Barriers to Gene FlowCYP6P9에 의해 주도되는 피레스로이드에 대한 대사 저항성의 선택적 선택의 서명은 말라리아 매개체인 Anopheles funestus에서 유전자 흐름에 대한 현대적 장벽을 드러낸다.Article Published on 2020-11-052024-08-11 Journal: Genes [Category] 말라리아, [키워드] Africa Anopheles funestus CYP6P9a gene gene flow resistance [DOI] 10.3390/genes11111314 PMC 바로가기 [Article Type] Article
Phylogenetic background and habitat drive the genetic diversification of Escherichia coli계통발생적 배경과 서식지가 대장균의 유전적 다양화를 주도Research Article Published on 2020-06-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adaptation adaptive Analysis analyzed Antibiotic resistance association Author Bacteria Bacterial birds clinical isolates clone commensal contribute determine Divergence driven by E . coli early stage element elements epidemiological epidemiologically Escherichia coli Evolution explain facilitate Factor fecal fecal contaminations Frequency gene flow gene transfer Genes Genetic genetic background genetic diversity genetic information Genome group gut bacteria habitat heterogeneous highest horizontal gene Horizontal gene transfer Human humans information investigated isolate isolates Isolation lead lineages linear mammals marker mechanism opportunistic pathogen paradigm pathogen pathogenic Phylogenetic Phylogeny poultry previous study sequence species strain Strains These data traits transfer Variation variations virulence virulence factors water while whole genome widespread wild animal wild animals [DOI] 10.1371/journal.pgen.1008866 PMC 바로가기 [Article Type] Research Article
An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons말라리아 매개체 Anopheles funestus의 살충제 저항성의 아프리카 전역 게놈 진화에는 선택적 스윕, 복제 수 변이, 유전자 전환 및 트랜스포존이 포함됩니다Research Article Published on 2020-06-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] alleles Analysis Anophele approach bed net complex copy number cytochrome P450 driven by Effectiveness Evidence evidence of Evolution exhibited gene conversion gene flow Genes genetic diversity genomic genomic change genomic region glutathione greater haplotypes highlighting independent insecticide insecticides insertion Intervention Local loci locus malaria malaria control malaria vector management metabolic Metabolic resistance molecular molecular evolution Multiple performed Population pyrethroid respond risk selection pressure selective sweep selective sweeps signature Spread Temporal transposon Variation variations vector control whole genome [DOI] 10.1371/journal.pgen.1008822 PMC 바로가기 [Article Type] Research Article
Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria나이지리아 라고스 지역 인구에서 말라리아 백신 후보인 플라스모디움 팔시파룸 망상적혈구 결합 단백질 유사체-5의 유전적 다형성Research Published on 2020-01-062024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] gene flow haplotypes histocompatibility linkage Polymorphisms Reticulocyte-binding protein homologue-5 Unstructured regions [DOI] 10.1186/s12936-019-3096-0 PMC 바로가기 [Article Type] Research
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the “endemic Burkitt Lymphoma belt”"풍토병 Burkitt 림프종 벨트"의 사하라 사막 이남 인구에서 유전자 흐름과 말라리아에 의한 자연 선택의 유전 적 특징Research Article Published on 2019-03-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Affect African Analysis association ATP2B4 baseline Burkitt lymphoma calcium Cancer characterization characterized chronic infection coding complex confluence determine disease East Effect Endemic erythrocytes event Evidence evidence of expressed facilitate gene flow Genetic genomic genomic data genotyped Great Lake Great Lakes group groups highest Hypothesis incidence individual intensity malaria Migration mixture natural natural selection North occurred Occurrence opposite pediatric Population populations Positive selection predominant SNP sub-Saharan Africa Support Transmission Uganda West [DOI] 10.1371/journal.pgen.1008027 PMC 바로가기 [Article Type] Research Article
Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens재결합 병원체에서 개체군 역학 및 선택을 측정하기 위한 혈통별 식별 분석Research Article Published on 2018-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] added addition Analysis antimalarial antimalarial drug Artemisinin Asia can be used clonal expansion comparison Comparisons country Critical critical regions dataset descent determine disease disease control disease transmission Diseases distributions drug resistance Efficacy effort evaluate events Exploratory analysis gene flow genetic diversity genetic study Genome genomes genomic genomic data genomic region Haplotype IBD identification identify independent infections Infectious disease Infectious diseases isolate isolates lack loci malaria methodology microorganism microorganisms multiple infections natural selection Organisms overlap pathogen Pathogens Plasmodium Plasmodium falciparum population bottleneck population bottlenecks populations Positive selection reduced regions selected selection pressure sequencing data Spread statistical methodologies statistical methodology statistical model Transmission Treatment whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007279 PMC 바로가기 [Article Type] Research Article
Evolutionary history of Tibetans inferred from whole-genome sequencing전체 게놈 시퀀싱으로 추론한 티베트인의 진화사Research Article Published on 2017-04-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive addition allele altitude adaptation Analysis candidate gene Candidates conducted demography demonstrated Denisovan detect EGLN1 EPAS1 Evidence evidence of gene flow Genes Genetic genetic variants Genome Haplotype haplotypes individuals involved KCTD12 Local natural selection no evidence of performed Population Positive selection PTGIS recent sequenced similarity subject subpopulation Tibetan Plateau unique variant VDR whole-genome whole-genome sequencing [DOI] 10.1371/journal.pgen.1006675 PMC 바로가기 [Article Type] Research Article
Restriction to gene flow is associated with changes in the molecular basis of pyrethroid resistance in the malaria vector Anopheles funestusArticle Published on 2017-01-102024-08-27 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] Anopheles funestus cytochrome P450 gene flow malaria pyrethroid resistance.
Evolutionary Dynamics of Influenza A Viruses in US Exhibition SwineArticle Published on 2016-01-152023-06-02 Journal: The Journal of Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Evolution exhibition animals gene flow Genomics Human-animal interface influenza A virus swine United States [DOI] 10.1093/infdis/jiv399 PMC 바로가기
Adaptive introgression in an African malaria mosquito coincident with the increased usage of insecticide-treated bed netsArticle Published on 2015-01-202024-08-29 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] Anopheles gambiae gene flow hybridization KDR knockdown resistance.