Gene ontology – Page 2 – Communicable Diseases Research

Serum Proteome Signatures of Anti-SARS-CoV-2 Vaccinated Healthcare Workers in Greece Associated with Their Prior Infection Status

Article

Published on 2022-09-052022-11-15
Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, 진단,

RNA sequence analysis of nasopharyngeal swabs from asymptomatic and mildly symptomatic patients with COVID-19

Research article

Published on 2022-09-012022-10-05
Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] Analysis Asymptomatic autophagy Bacterial Cell changes in Coinfection complement COVID-19 Differential gene expression disease severity dysregulation Epigenetic gene expression profile Gene ontology group identify in both group investigated involved mildly symptomatic patient Modification modulation mRNA Nasopharyngeal swab objective outcome Patient patients performed profile progression proportion reduction in Result retrieved RNA RNA sequence SARS-CoV-2 SARS-COV-2 infection Sequence analysis Sequencing Streptococcus pneumoniae symptomatic symptomatic individuals Symptomatic patients the disease transcriptomic transcriptomics translation Transport upregulation Viral genome assembly viral variant with COVID-19
[DOI] 10.1016/j.ijid.2022.06.035 [Article Type] Research article

Discovering common pathogenetic processes between COVID-19 and sepsis by bioinformatics and system biology approach

Article

Published on 2022-08-312022-11-15
Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome addition Analysis approach bioinformatics Biomarker Blood caused clinical manifestations Clinical practice Coagulopathy Corona Coronavirus-2 COVID-19 Critically ill Critically ill patient Cytokine storm database DEGs demonstrated diagnostic differentially expressed differentially expressed gene differentially expressed gene (DEG) disease drug molecule enrichment analysis functional functional enrichment Gene Expression Omnibus gene expression profile Gene ontology gene regulatory network genetic link genetic mechanism GEO high mortality rate hub gene hypercoagulable Inflammatory response Interaction ITGAM molecular docking molecular mechanism multiple organ dysfunction neutrophil dysfunction pandemic Pathogenesis pathogenesis of COVID-19 pathway potential therapeutic agents progesterone protein-protein interaction Protein–protein interaction protein–protein interaction (PPI) receptor Regulatory Research respiratory infectious disease resulting risk SARS-CoV-2 screened Sepsis sepsis patient Septic shock severe COVID-19 signaling pathway similarity Spread syndrome System biology Systems biology Treatment were used with COVID-19
[DOI] 10.3389/fimmu.2022.975848 PMC 바로가기

Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysis

COVID-19에 대한 새로운 호스트 기반 진단 바이오마커 패널 식별: 전혈/비인두 전사체 메타 분석

Meta-Analysis

Published on 2022-08-032022-09-11
Journal: Molecular Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술,

[키워드] Accuracy acute respiratory illness acute respiratory illnesses Analysis applied ARI bioinformatics Biomarker Blood Cell cell cycle Characteristics Combination complementary controls COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 sample cross cytokine cytokine production Data integration dataset Defense detect diagnose diagnostic diagnostic biomarker Diagnostic biomarkers Diseases eight enhancement feature gene expression profile Gene ontology HCs healthy control healthy controls Host host gene host response identifying Immune cell improvement Improvements independent indicated induce Infection Inflammatory interferon introduced lack machine learning algorithm Machine learning algorithms marker Meta-analysis nasopharyngeal Nasopharyngeal swab Ontology Pathogenesis pathway pathway enrichment patients with COVID-19 proportion Random forest respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis selected swab sample System Systems biology Transcriptome upregulation Viral virus Whole blood
[DOI] 10.1186/s10020-022-00513-5 PMC 바로가기 [Article Type] Meta-Analysis

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience [Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2

SARS-CoV-2에 대한 인간 신경모세포종 세포의 전사적 풍경

Article

Published on 2022-07-062022-09-11
Journal: BMC neuroscience [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis applied approach Cell cells Central nervous system changes in chemokines contagious coronavirus Cytokines decrease differentially expressed gene Differentially expressed genes downregulated function functions Gene ontology host mRNA identify Infection Injury involved knowledge Kyoto mechanism mRNA mRNAs Neuroinflammation Neurological symptom Neurological symptoms NF-κB pathogenic Pathways Patient performed receptors reported RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly SK-N-SH cells. transcriptional profile transcriptional profiles transcriptomic Treatment upregulated
[DOI] 10.1186/s12868-022-00728-6 PMC 바로가기 [Article Type] Article

Screening the hub genes and analyzing the mechanisms in discharged COVID-19 patients retesting positive through bioinformatics analysis

생물정보학 분석을 통해 퇴원한 코로나19 환자 재검사에서 허브 유전자 스크리닝 및 기전 분석

Article

Published on 2022-07-012022-09-11
Journal: Journal of Clinical Laboratory Analysis [Category] 유전자 메커니즘,

[키워드] ALKBH6 AMBRA1 Analysis analyzed ANAPC1 Apoptosis ATP1A1 ATP1A1-AS1 bioinformatics Bioinformatics analysis convalescent COVID-19 COVID-19 patient COVID-19 patients cytoHubba differentially expressed gene discharge discharged DISP1 DOCK4 down-regulated down-regulated gene enrichment analysis expression data FAM149B1 FAM241B Gene Expression Omnibus Gene ontology Genes genomes GEO healthy control hub genes IGLV1-40 immune immune response KEGG Kyoto LRRC69 management mechanism MICAL3 Microarray MIR1249 mRNA Pathogenesis Patient patients PLPPR2 positive PPI PPI network Prognosis prognostic protein-protein interaction PSMG1 R software Rab11b RAB11B-AS1 retesting positive after discharged. Ribonucleic acid risk screened Screening selected significant enrichment SNRPD1 SNRPD2 SORT1 TP53BP1 TRAV18 two group two groups up-regulated virus was performed
[DOI] 10.1002/jcla.24495 PMC 바로가기 [Article Type] Article

Computational modeling of human-nCoV protein-protein interaction network

Article

Published on 2022-07-012023-07-07
Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년),

[키워드] drug target Fuzzy model Gene ontology High-quality interactions Human-nCoV interactions Protein interaction network analysis SARS-CoV2 Spreadability index Spreader nodes Susceptible-infected-susceptible model.
[DOI] 10.1016/j.ymeth.2021.12.003 PMC 바로가기

Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?

SARS-CoV-2가 표적으로 하는 고혈당증, 당뇨병 합병증 및 인간 단백질의 유전자 네트워크: 동반 질환의 분자적 근거는 무엇입니까?

Article

Published on 2022-06-292022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘,

[키워드] ACE2 ANDSystem Angiogenesis applied approach associative Basis Beta beta cell Beta cells bioinformatics Bioinformatics analysis BRD2 Cell Comorbidity Complication complications COMT COVID-19 CTSB CTSL defined degranulation determine diabete diabetes Diabetic diabetic complications disorder DNMT1 DPP4 dysfunction enrichment analysis ERP44 expand F2RL1 GDF15 gene networks Gene ontology General population GPX1 HDAC2 HMOX1 Human HYOU1 hyperglycemia hypoxia IDE identify immune Inflammatory response insulin insulin resistance intracellular protein involved LOX mechanism metabolism molecular basis molecular network network NUTF2 organ damage oxygen pathophysiological patients with diabetes PCNT PLAT Platelet protease Proteins RAB10 reactive oxygen specy reconstructed Regulation RHOA SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry receptor SCARB1 SELENOS severe COVID-19 TMPRSS2 Vascular
[DOI] 10.3390/ijms23137247 PMC 바로가기 [Article Type] Article

Potential Material Basis of Yupingfeng Powder for the Prevention and Treatment of 2019 Novel Coronavirus Pneumonia: A Study Involving Molecular Docking and Molecular Dynamic Simulation Technology

2019년 신종 코로나바이러스 폐렴의 예방 및 치료를 위한 Yupingfeng 분말의 잠재적 재료 기반: 분자 도킹 및 분자 동적 시뮬레이션 기술 관련 연구

Article

Published on 2022-06-242022-09-11
Journal: BioMed Research International [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] 2019 novel coronavirus 2019 novel coronavirus pneumonia Algorithm Analysis analyzed AutoDock Basis binding Chinese common disease complexes component Coronavirus pneumonia Cytoscape software database disease DisGeNET docking dynamic enrichment analysis free energy Free energy calculation Free energy calculations Gene ontology GeneCard generate HIF-1 hydrogen Hydrogen bond identify ingredient Interaction investigated Involving KEGG pathway MAPK material mechanism molecular molecular docking molecular dynamic simulations novel Novel coronavirus novel coronavirus pneumonia Pathways performed Pneumonia Potential potential mechanism powder predict Predictive prevention protease Protein protein-protein interaction receptor retrieved SARS-CoV-2 selected Simulation STRING database T cell T cell receptor target target gene Target genes TCMSP technology TNF Toll-like receptor Topology Traditional Chinese medicine Treatment VEGF VEGF signaling was used were used
[DOI] 10.1155/2022/7892397 PMC 바로가기 [Article Type] Article