Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19성숙한 호중구와 NF-κB에서 IFN으로의 전환은 COVID-19에서 통합된 질병 회복 역학을 결정합니다Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] 바이오마커, 유전자 메커니즘, [키워드] Blood Cell cell deconvolution cellular cellular and molecular Cellular and molecular mechanisms changes changes in clinically courses COVID-19 decrease determine differentiation disease disease modeling disease recovery Effect framework Gene regulation heterogeneous homeostasis immune immunology implication indication interferon Kinetics mechanisms Medicine neutrophil NF-κB other disease other diseases outcome Patient presenting Regulatory restoration resulting severe COVID-19 Systems biology T cell T cell activation the disease tissues transcriptomes viral infection [DOI] 10.1016/j.xcrm.2022.100652 PMC 바로가기 [Article Type] Article
Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체Article Published on 2022-04-142022-09-11 Journal: Genome Biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 3D genome organization 3p21.31 association CCR1 CCR2 CCR5 Chemokine receptor chromatin Control COVID-19 CTCF elevated epigenomic Gene regulation Genes Genetic genetic association Genome Genome-wide association studies GWAS hallmark Hospitalization increased expression infiltration inflammatory monocyte inflammatory monocytes locus Macrophage macrophages mechanism monocyte Monocytes organ rationale Regulatory regulatory element risk SARS-CoV-2 SARS-COV-2 infection severe COVID-19 SNP variant [DOI] 10.1186/s13059-022-02669-z PMC 바로가기 [Article Type] Article
In silico analysis highlighting the prevalence of BCL2L1 gene and its correlation to miRNA in human coronavirus (HCoV) genetic makeupArticle Published on 2022-02-282023-06-15 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), MERS, SARS, [키워드] CDC, Control and Prevention COVID-19 COVID-19, coronavirus disease DNA, Deoxyribonucleic acid Gene regulation HCoV, human coronavirus IFN, interferon miRNA miRNA-gene regulation MiRNA, MicroRNA ncRNA, Non-coding RNA PPI analysis PPI, Protein-Protein Interaction SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SFN, Steiner Forest Network TF, Transcription factor TRRUST, Transcriptional regulatory relationships unraveled by sentence-based text-mining WHO, World Health Organization [DOI] 10.1016/j.meegid.2022.105260 PMC 바로가기 [Article Type] Article
Crosstalk between Hepatitis B Virus and the 3D Genome StructureReview Published on 2022-02-212023-06-02 Journal: Viruses [Category] B형 간염, [키워드] DNA viruses Gene regulation HBV HBV cccDNA spatial nuclear organization [DOI] 10.3390/v14020445 PMC 바로가기 [Article Type] Review
Immune Response Is Key to Genetic Mechanisms of SARS-CoV-2 Infection With Psychiatric Disorders Based on Differential Gene Expression Pattern Analysis면역 반응은 차등 유전자 발현 패턴 분석을 기반으로 한 정신 장애를 가진 SARS-CoV-2 감염의 유전 기전의 핵심입니다Immunology Published on 2022-02-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 approach bioinformatics Bipolar disorder brain tissue clinical manifestation collected comprehensive analysis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set data sets DEGs depressive depressive disorder differentially expressed gene disorder enrichment analysis enzyme Evidence expressed functional enrichment Gene regulation gene regulation networks Genetic genetic mechanism genetic mechanisms identify immune-related gene immune-related genes incidence individual infected with SARS-CoV-2 infecting Infection infection with SARS-CoV-2 Inflammatory responses Interaction lead leads major depressive disorder MAPK mechanism Mental disorder Mental Disorders mental health disorders Mortality overlapping pathway Patient patients with COVID-19 pattern performed Peripheral blood peripheral blood cell peripheral blood cells Protein–protein interaction Psychiatric psychiatric diagnose psychiatric disorder Psychiatric disorders psychiatric illness receptor reported Research respiratory Respiratory system response SARS-CoV-2 Schizophrenia severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly higher susceptible susceptible cell Systems biology TGF-β Therapies Treatment various tissues were used Whole blood [DOI] 10.3389/fimmu.2022.798538 PMC 바로가기 [Article Type] Immunology
Betacoronavirus-specific alternate splicingArticle Published on 2022-01-222023-06-14 Journal: Genomics [Category] MERS, SARS, [키워드] alternative splicing Betacoronavirus COVID-19 Gene regulation SARS-CoV-2 [DOI] 10.1016/j.ygeno.2022.110270 PMC 바로가기 [Article Type] Article
Mga Spn is a negative regulator of capsule and phosphorylcholine biosynthesis and influences the virulence of Streptococcus pneumoniae D39article Published on 2021-12-312024-09-01 Journal: Virulence [Category] 폐렴구균 감염증, [키워드] Capsule Gene regulation MgaSpn Phosphorylcholine Streptococcus pneumoniae [Article Type] article
Immuno-Endocrinology of COVID-19: The Key Role of Sex HormonesCOVID-19의 면역 내분비학: 성 호르몬의 주요 역할Review Published on 2021-12-022022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response androgen Clinical studies clinical study coronavirus coronavirus 2019 disease COVID-19 COVID-19 pathogenesis COVID-19 severity Cytopathic effect disease severity element Estrogen Evidence Factor Factors fatality Gender Gene regulation hormone hyper-inflammatory response identify immune response immune responses immuno-endocrinology include Infection Injury involved mechanism optimization Pathogenesis personalised regulated Regulation role SARS-CoV2 severity Sex sex hormone Sex hormones susceptibility target targets therapeutic intervention tissue injury tissue specific Treatment outcome Trial [DOI] 10.3389/fendo.2021.726696 PMC 바로가기 [Article Type] Review
Role of microRNAs in COVID-19 with implications for therapeutics치료제에 대한 의미와 함께 COVID-19에서 microRNA의 역할Review Published on 2021-12-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alleviate Anti-miRNA therapy approved biological processes caused changes in Complication Control coronavirus COVID-19 diabetes disease dysregulation effort FDA focus Gene regulation heart failure Host human disease humans immune response implication increased risk infect kidney kidney problems majority microRNA miRNA miRNA therapy miRNAs pathogenic pathogenicity Patient problems progression Regulation respiratory respiratory diseases RNA virus role SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease severity of COVID-19 shown the patient Therapies [DOI] 10.1016/j.biopha.2021.112247 PMC 바로가기 [Article Type] Review
The role of microRNAs in solving COVID-19 puzzle from infection to therapeutics: A mini-reviewReview Published on 2021-11-142022-10-04 Journal: Virus research [Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Affect Biomarker caused circulating miRNA Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 patient demonstrated develop diagnose disease disorders dysregulation expressed expression expression level future therapeutic Gene Expression Gene regulation Health Host Infection inhibit involved lung adenocarcinoma microRNA MicroRNAs miRNA miRNA-based therapeutics miRNAs modulate molecular mechanism non-coding RNA nucleotides Pathogenesis Potential biomarker Proteins regulate researcher SARS-CoV-2 SARS-CoV-2 variants severity the disease therapeutic target TMPRSS2 Treatment type 2 diabetes Vaccine viral disease virus [DOI] 10.1016/j.virusres.2021.198631 PMC 바로가기 [Article Type] Review