genetic polymorphisms – Page 2 – Communicable Diseases Research

Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings

Neurology

Published on 2021-08-172022-11-01
Journal: Frontiers in Neurology [Category] COVID-19,

Genomic Association vs. Serological Determination of ABO Blood Types in a Chinese Cohort, with Application in Mendelian Randomization

멘델식 무작위 배정에 적용한 중국 코호트에서 ABO 혈액형의 게놈 연관성 대 혈청학적 결정

Article

Published on 2021-06-242022-09-10
Journal: Genes [Category] MERS, 변종, 유전자 메커니즘,

Association of the host genetic factors, hypercholesterolemia and diabetes with mild influenza in an Iranian population

Research

Published on 2021-03-252023-06-07
Journal: Virology Journal [Category] 신종인플루엔자,

[키워드] diabetes genetic polymorphisms hypercholesterolemia Influenza Iran
[DOI] 10.1186/s12985-021-01486-3 PMC 바로가기 [Article Type] Research

A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach

신종 전염병의 맥락에서 T-세포 에피토프 발견 및 백신 설계를 가속화하기 위한 프로테옴 전체 면역정보학 도구: 민족 중심 접근

Immunology

Published on 2021-02-262022-09-11
Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘,

[키워드] accelerate Accuracy Analysis AUC build caused CD4+ T-cell CD8+ ChAdOx1 ChAdOx1 vaccine clinical trials comparable complicate Context contribute coronavirus country Coverage COVID-19 pandemic criteria disease distribution effective Emerging infectious disease Emerging infectious diseases emerging-infectious disease Epidemics epitope epitope clusters epitope density epitope discovery epitope mapping Epitope-based vaccine Epitopes Ethnic groups Ethnicity frequencies Frequency genetic polymorphisms geographic distributions glycoprotein HLA HLA allele HLA allele frequencies HLA allele frequency HLA alleles human leukocyte antigen immune response immune responses immune responsiveness immune system immunodominant immunoinformatics in silico Infectious diseases investigated Japanese leukocyte Mortality NetMHCpan optimization Pathogens peptide Phase III clinical trials polymorphism Population predicted protein antigen protein antigens proteome Region retrieved SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-like coronavirus spike glycoprotein T-cell T-cell epitope T-cell epitopes the SARS-CoV-2 utility vaccination Vaccination strategy Vaccinations Vaccine vaccine candidates Vaccine design vaccine-induced immune response vaccine-induced immune responses Variability Variation virus
[DOI] 10.3389/fimmu.2021.598778 PMC 바로가기 [Article Type] Immunology

Precision Medicine and Public Health: New Challenges for Effective and Sustainable Health

Review

Published on 2021-02-162022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors

한센병 환자에서의 B형 간염 바이러스 감염: 렉틴 경로 및 보체 수용체 활성화를 저해하는 다형성에 대한 사례

Original Research

Published on 2021-02-112023-06-03
Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, 한센병,

[키워드] complement 3b receptors complement system proteins ficolin genetic polymorphisms hepatitis B leprosy mannose-binding lectin mannose-binding protein-associated serine proteases
[DOI] 10.3389/fimmu.2020.574457 PMC 바로가기 [Article Type] Original Research

Molecular Mechanisms of Vascular Damage During Lung Injury

폐 손상 중 혈관 손상의 분자 메커니즘

Review

Published on 2021-01-012022-09-11
Journal: Advances in experimental medicine and biology [Category] 유전자 메커니즘,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ADRS alveolar epithelium ARDS association behavioral risk factors change contribute COVID-19 Cytokines damage disease disease risk Disruption DNA DNA methylation endothelial activation Enzyme inhibitor Enzyme inhibitors Epigenetic epigenetics epithelial Epithelial barrier evaluate experimental model experimental models explained Factor focus Genetic genetic factors Genetic polymorphism genetic polymorphisms Genetic predisposition high mortality rate histone Histone acetylation, DNA methylation Hospitalization humans increased vascular permeability Inflammation Inflammatory response Injury intensive care lung endothelial Lung injury mechanism Modification molecular mechanism molecular mechanisms Mortality occur offer Pathogenesis phenotypic potential therapeutic target Prevent pro-inflammatory cytokines promote Research respiratory distress Respiratory distress syndrome Risk factors susceptibility syndrome systemic and local treat variety Vascular damage Vascular endothelium vascular permeability
[DOI] 10.1007/978-3-030-68748-9_6 PMC 바로가기 [Article Type] Review

Residence, Clinical Features, and Genetic Risk Factors Associated with Symptoms of COVID-19 in a Cohort of Older People in Madrid

마드리드의 노인 집단에서 COVID-19의 증상과 관련된 거주, 임상 특징 및 유전적 위험 요인

Observational Study

Published on 2021-01-012022-09-11
Journal: Gerontology [Category] 변종, 임상, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 affected alcohol allele ApoE APOE gene association clinical clinical condition Clinical features Clinical severity coffee cognitive cognitive deterioration Cognitive impairment Cohort collected Comorbidities coronavirus Coronavirus infection COVID-19 Deterioration died disease severity Diseases exploratory study Factor Fatality rate frailty genetic polymorphisms incidence indicate Madrid males Measures Mortality mortality rate neurodegenerative Nursing nursing home Older older people older population overall mortality pandemic potential risk reported symptom residence respiratory risk factor Risk factors severe acute respiratory syndrome Coronavirus severity significantly smoking Spain symptomatic symptomatic COVID-19 symptoms of COVID-19 Systolic blood pressure telephone survey Vallecas Project. variant Volunteer
[DOI] 10.1159/000513182 PMC 바로가기 [Article Type] Observational Study

Strong Correlation between the Case Fatality Rate of COVID-19 and the rs6598045 Single Nucleotide Polymorphism (SNP) of the Interferon-Induced Transmembrane Protein 3 ( IFITM3 ) Gene at the Population-Level

인구 수준에서 코로나19의 치사율과 인터페론 유도 막관통 단백질 3(IFITM3) 유전자의 rs6598045 단일 뉴클레오티드 다형성(SNP) 사이의 강한 상관관계

Brief Report

Published on 2020-12-302022-09-10
Journal: Genes [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 1000 Genomes Project ABO ABO gene ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition allele allele frequency angiotensin angiotensin I best Biomarker calculated Case fatality rate case fatality rates caused coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 case COVID-19 cases death distribution enzyme ethnic group Ethnic groups evaluated Fatality rate Genes Genetic Genetic polymorphism genetic polymorphisms Health Organization identify IFITM3 IL6 Infection interferon Interferon-induced transmembrane protein 3 interleukin 6 knowledge leucine LZTFL1 mechanism nucleotide pandemic disease Pathogenesis pathogenesis of COVID-19 performed polymorphism Polymorphisms protease Protein protein 3 Rate regression analysis reported respiratory risk SARS-CoV-2 SAS version 9.4 Serine serine 2 severe acute respiratory syndrome Coronavirus single nucleotide Single nucleotide polymorphism SNP Strong TMPRSS2 Transcription transmembrane transmembrane protein WHO World Health Organization
[DOI] 10.3390/genes12010042 PMC 바로가기 [Article Type] Brief Report

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

인터페론 신호 전달의 게놈 전체 단백질 정량적 형질 유전자좌 매핑에 의해 밝혀진 다발성 경화증 보호 HLA 클래스 I 대립 유전자의 기능

Research Article

Published on 2020-10-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addition Affect allele alleles Analysis Antigen presentation antigen-presenting function associations Autoimmune B and T cells B cell B cells CD27 Cell characterization contribute cytokine Cytokines demonstrated disease disease-associated Diseases Effect function functions genetic association Genetic association studies genetic associations genetic data Genetic polymorphism genetic polymorphisms genome-wide significant genotyped healthy individual healthy individuals HLA class I HLA class I alleles HLA locus HLA-A HLA-A*02 HLA-B HLA-J Host identify IFN IFNAR2 IFNs IGD Immune cell immune cells immune system immune-mediated disease immune-mediated diseases independent Infectious diseases Inflammatory interferon interferon receptor interferons interferons (IFNs interferons (IFNs) loci memory B cells microorganisms molecular mechanism molecular mechanisms mRNA expression multiple sclerosis neurologic nucleotide other disease other diseases Pathogenesis pathogenic patients performed protein level pseudogene receptor reduced regulated replicated response sclerosis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs specific type T cell T cells These data to define transcriptional regulation Type I IFN type I interferon type II IFN virus viruses
[DOI] 10.1371/journal.pgen.1009199 PMC 바로가기 [Article Type] Research Article