Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysisArticle Published on 2022-02-032022-10-04 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, [키워드] analyses Analysis Apolipoprotein A association associations asymptomatic infection attenuate Biomarker Blood BMI clinical evaluation clinical manifestations conducted correlation COVID-19 pandemic COVID-19 severity death diabete Epidemiology Genetic genetic architecture Genetic predisposition to disease Genome-wide association studies genomic genomic region HDL Hospitalization Linkage disequilibrium Mendelian randomization study parameter parameters Phenotypes positive produced Protective provide regression analysis Removing Research retinol risk factor robust sensitivity analysis severe COVID-19 Shortness of breath smoking therapeutic target [DOI] 10.1038/s41598-022-05832-5 PMC 바로가기 [Article Type] Article
Diminished amplification of SARS-CoV-2 ORF1ab in a commercial dual-target qRT-PCR diagnostic assay상업용 이중 표적 qRT-PCR 진단 분석에서 SARS-CoV-2 ORF1ab의 증폭 감소Article Published on 2022-02-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (RdRp) amplification Cobas Ct-value Ct-values diagnostic diagnostics diminished discrepancy Dual-target assay E-gene false-negative false-negative results genomic region highlight house limit molecular molecular diagnostics Molecular diagnostics SARS-CoV-2 nsp10 nucleotide nucleotide mutation ORF ORF1 ORF1ab ORF1ab mutations PCR PCR amplification primer probe qRT-PCR RdRP resulting SARS-CoV-2 SARS-CoV-2 PCR tests SARS-CoV-2 variant SARS-CoV-2. Surveillance target region target regions unique [DOI] 10.1016/j.jviromet.2021.114397 PMC 바로가기 [Article Type] Article
Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging Research Published on 2022-01-202022-10-05 Journal: Nature Aging [Category] 바이오마커, 유전자 메커니즘, [키워드] Blood level component detect detrimental drug target ENhance Evidence exceptional Finnish frailty Genetic genetic architecture genetics Genome-wide association study genomic region HTT identify independent Japanese Length loci LPA MAML3 mendelian randomization Mental mother phenotype physical Quality of life robust survival target vascular cell adhesion VCAM1 [DOI] 10.1038/s43587-021-00159-8 [Article Type] Research
Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and ReplicationArticle Published on 2022-01-182022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] A97V antiviral activity autonomous BAC Bacterial Cell culture chromosome clone coronavirus COVID-19 COVID-19 pandemic decrease drug Efficacy exhibited experiments F480L facilitated fluorescent full-length SARS-CoV-2 functional Genes genomic region genomic RNA GFP growth Healthcare system in vitro infectious virus inhibited membrane modify molecular clone Mutation nanoluciferase non-infectious Nsp12 P323L phenotype platform polymerase polymorphism Protein provide recombinant Remdesivir Replication replicon reporter Research resistance RNA virus SARS-CoV-2 SARS-CoV-2 mutants SARS-CoV-2 susceptibility SARS-CoV-2 variants sequence Substitution susceptibility System transcript Treatment utility Vaccines Vero E6 cell viral gene virus virus isolate [DOI] 10.3390/v14020172 PMC 바로가기 [Article Type] Article
Sequence analysis for SNP detection and phylogenetic reconstruction of SARS-cov-2 isolated from Nigerian COVID-19 casesResearch article Published on 2022-01-012022-10-05 Journal: New Microbes and New Infections [Category] 변종, 유전자 메커니즘, 치료기술, [키워드] 2019-nCoV 3′UTR accounted addition Analysis average base causative pathogen characteristic characterized clade Clustering community transmission conserved Coronaviridae COVID-19 COVID-19 case Culture D614G D614G mutation disease distribution family Frequency GenBank genome sequence Genome sequence data genomic genomic region genus Betacoronavirus GISAID GISAID database highest include index case Intensive likelihood Lineage MAFFT morbidity and mortality Multiple mutants New coronavirus Nigeria Novel coronavirus ORF10 ORF1ab pandemic Phylogenetic Phylogenetic tree Phylogeny reference genome Region regions Result retrieved SARS-CoV-2 SARS-CoV-2 genome sequence severe respiratory symptom significantly higher similarity SNP SNPs spike gene Treatment Version viral sequences virus was done were used widespread [DOI] 10.1016/j.nmni.2022.100955 [Article Type] Research article
A novel SARS-CoV-2 related coronavirus in bats from Cambodia캄보디아 박쥐의 신종 SARS-CoV-2 관련 코로나바이러스Article Published on 2021-11-092022-09-10 Journal: Nature Communications [Category] MERS, SARS, 치료기술, [키워드] Asia bat China coronavirus coronavirus Coronaviruses COVID-19 pandemic distribution Epidemiology genomic region Geographic distribution identify identity indicate metagenomic sequencing metagenomics molecular evolution MOST nucleotide related virus related viruses reported reservoir responsible SARS-CoV-2 Sequencing Surveillance these viruses virus viruses [DOI] 10.1038/s41467-021-26809-4 PMC 바로가기 [Article Type] Article
Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR유연한 CFDR을 사용하여 GWAS 발견을 향상시키기 위해 임의의 분포에서 보조 데이터 활용Research Article Published on 2021-10-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach association associations Asthma auxiliary boost can be used category complex complex diseases Conditioning Control correlation covariate detect distribution distributions error rate Evidence evidence of experiments extension false discovery rate FDR functional Genetic genetic association genetic associations Genetic variant genetic variants Genome-wide association studies genomic genomic data genomic region GWAS Human genome identify implementation IMPROVE increase independent Interpretation iterations motivation not significant P -value Pleiotropy power provide Region required resource robust Sample size sensitivity SNP SNPs Statistical power Support Test statistics threshold traits UK Biobank data while [DOI] 10.1371/journal.pgen.1009853 PMC 바로가기 [Article Type] Research Article
Analysis of SARS-CoV-2 Genomes from West Java, IndonesiaArticle Published on 2021-10-182022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] analyses Analysis analyzed B.1.617.2 carried collected decrease Delta distribution dominant variant examined female Frequency genomic region GISAID highest hotspot Indonesia lack male Mutation non-structural protein Non-synonymous mutation nucleocapsid ORF3a protein prevalent Protein protein stability required Research retrieved SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-CoV-2 protein sequence sequenced stability submitted variant VoC West West Java [DOI] 10.3390/v13102097 PMC 바로가기 [Article Type] Article
COVID-19: Impact on linguistic and genetic isolates of IndiaCOVID-19: 인도의 언어 및 유전적 분리에 대한 영향Brief Communication Published on 2021-10-112022-09-12 Journal: Genes and Immunity [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] affected analysed Asia Brazil Community coronavirus SARS-CoV-2 COVID-19 ethnic group extreme General population genetic isolate genomic region greater group homozygosity homozygous Impact impacted increase India Infectious disease Isolation knowledge management pandemic Population rapid expansion reached reported risk Sery shown South South Asian Structural variation suggested susceptibility Till viral infection [DOI] 10.1038/s41435-021-00150-8 PMC 바로가기 [Article Type] Brief Communication
A more accurate method for colocalisation analysis allowing for multiple causal variants다중 인과 변이체를 허용하는 공동 국소화 분석을위한보다 정확한 방법Research Article Published on 2021-09-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy analysis Analysis approach association assumption can be used causal variant Combination Conditioning disease risk Effect evaluated Evidence Genetic genetic association Genetic association studies genetic variants Genome-wide association studies Genome-wide association study genomic region GWAS help human disease lead question Research risk statistical Support variant variants [DOI] 10.1371/journal.pgen.1009440 PMC 바로가기 [Article Type] Research Article