Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene네바다 환자의 게놈 감시는 RdRp 유전자에 돌연변이가 있는 독특한 SARS-CoV-2 변이체의 유행을 나타냈습니다Article Published on 2021-01-202022-09-11 Journal: Journal of genetics and genomics = Yi chuan xue ba [Category] 변종, [키워드] accessory protein accessory proteins amplification association changed circulating circulation Community COVID-19 COVID-19 patient Culture determine diagnostic domain Evolution Frequency genome coverage Genome enrichment Genomic surveillance geographic locations humans Mutation Nsp12 Occurrence ORF1b orf1b 314. other variant other variants outbreak Patient Phenylalanine Phylogenetic relationship platform polymerase Prevalence proline public health RdRP RdRp gene reported required RNA RNA-dependent RNA polymerase robust RT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequenced Sequencing specimen swabs tested unique variant variants variants of SARS-CoV-2 Viral viral loads Wuhan-Hu-1 [DOI] 10.1016/j.jgg.2021.01.004 PMC 바로가기 [Article Type] Article
Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations3067 SARS-CoV-2 게놈의 대규모 게놈 분석을 통해 핫스팟 돌연변이의 클론 지리 분포와 풍부한 유전적 변이가 밝혀졌습니다.Research Article Published on 2020-11-102022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] accumulation Affect allele Analysis analyzed characterization China collected Comparative genomics country COVID-19 database distribution Evolution frequencies Frequency Genetic variant genetic variants Genetic variation Genomic analysis Genotype geographic location geographic locations global pandemic haplotypes hotspot mechanism mutated Mutation mutations Non-synonymous Non-synonymous mutation phylogeographic analysis Prevalence profile profiles recurrent mutation residue resulting reveal SARS-CoV-2 SARS-CoV-2 genes SARS-CoV-2 genome SARS-CoV-2 genomes selected selective severity shown Spread the epidemic the SARS-CoV-2 the SARS-CoV-2 genome therapeutic targets variant Viral viral infection virus whole-genome Wuhan Wuhan, China [DOI] 10.1371/journal.pone.0240345 PMC 바로가기 [Article Type] Research Article
Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19COVID-19 환자에서 급성 신장 손상의 병태생리 및 병리학Review Published on 2020-09-012022-09-11 Journal: Advances in chronic kidney disease [Category] SARS, 치료제, [키워드] Acute kidney injury AKI Chronic kidney disease Collapsing GN coronavirus COVID-19 deaths etiology geographic locations hospital discharge hospitalized patient hospitalized patients IMPROVE In-hospital Infectious disease Kidney disease Kidney failure Kidney injury knowledge mitigate Occurrence pathology pathology. pathophysiology Patient patients with AKI risk severity severity of illness survival Variability [DOI] 10.1053/j.ackd.2020.09.003 PMC 바로가기 [Article Type] Review
Estimation of SARS-CoV-2 mortality during the early stages of an epidemic: A modeling study in Hubei, China, and six regions in Europe전염병 초기 SARS-CoV-2 사망률 추정: 중국 후베이 및 유럽 6개 지역의 모델링 연구Research Article Published on 2020-07-282022-08-13 Journal: PLoS Medicine [Category] Biology and Life Sciences, COVID-19, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Affect affected age applied baseline biases calculated can be used Case–fatality ratio cause caused causes CFR changed China Clinical prognosis comparison Comparisons compartmental model coronavirus credible interval CrI date of onset death deaths disease early stage Epidemic estimate Estimated estimation Europe Factor Geographic difference Geographic differences geographic locations Germany Health Service healthcare heterogeneity highest IFR IMPROVE individual infected with SARS-CoV-2 Infection Infection transmission infection–fatality ratio investigated Italy less limitation lombardy lowest mathematical mathematical model measure MONITOR Mortality Older Outbreaks overall mortality Policy predict preferential ascertainment proportion public health ranged reduce Region reported required researcher respiratory right-censoring SARS-CoV-2 SARS-CoV-2 epidemic SARS-COV-2 infection sCFR SEIR severe acute respiratory syndrome Coronavirus Severe case severe cases severe symptoms Spain surveillance data susceptible-exposed-infected-removed Switzerland symptomatic case symptomatic case–fatality ratio the SARS-CoV-2 total size Transmission Transmission dynamics Transmission model [DOI] 10.1371/journal.pmed.1003189 PMC 바로가기 [Article Type] Research Article