Potamogeton perfoliatus L. Extract Attenuates Neuroinflammation and Neuropathic Pain in Sciatic Nerve Chronic Constriction Injury-Induced Peripheral Neuropathy in RatsOriginal Research Published on 2021-12-202024-09-02 Journal: Frontiers in Pharmacology [Category] 대상포진, [키워드] CD68 chronic constriction injury GFAp iNOS Potamogeton perfoliatus [DOI] 10.3389/fphar.2021.799444 PMC 바로가기 [Article Type] Original Research
Blood neurofilament light chain and total tau levels at admission predict death in COVID-19 patients입원 시 혈액 신경필라멘트 경쇄 및 총 타우 수치는 COVID-19 환자의 사망을 예측합니다Article Published on 2021-12-012022-09-11 Journal: Journal of Neurology [Category] 바이오마커, [키워드] Acidic Admission Asymptomatic Biomarker Blood Clinical outcome collected COVID-19 death in COVID-19 emergency room Evolution GFAp ICU indicated infected with SARS-CoV-2 intensive care intensive care unit investigated Kaplan-Meier curve Kaplan-Meier curves light chain marker Mild moderate Mortality neurofilament neurofilament light chain outcome Patient predict predictor Prognostic value Protein protein levels ROC SARS-CoV-2 severe disease significantly increased survival Tau tissue damage transfer UCH-L1. [DOI] 10.1007/s00415-021-10595-6 PMC 바로가기 [Article Type] Article
Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19COVID-19 이후 뇌 손상, 내피 손상 및 염증 마커가 증가하고 성별에 따른 변화를 나타냅니다.Research Published on 2021-11-272022-09-10 Journal: Journal of Neuroinflammation [Category] MERS, 바이오마커, [키워드] affected alteration Analysis analyzed association bioinformatics Bioinformatics analysis Brain brain injury chemokine chemokines Control controls COVID-19 COVID-19 cohort COVID-19 hospitalization Cytokines disease severity EIM elevated endothelial injury Express expressed GFAp IL10 IL15 IL1RA IL8 immune response Inflammation Inflammatory Inflammatory cytokine Inflammatory marker inflammatory markers Injury investigated IP10 male MAP2 marker matched controls MCP1 men Mortality multiplex objective organ positive profile respiratory Respiratory disease Result risk robust S100B SARS-CoV-2 Seven Sex sex differences significantly subject supplementary material susceptible syndecan Syndecan-1 TNFα were used women [DOI] 10.1186/s12974-021-02323-8 PMC 바로가기 [Article Type] Research
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Encephalitis Is a Cytokine Release Syndrome: Evidences From Cerebrospinal Fluid Analyses중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 뇌염은 사이토카인 방출 증후군입니다: 뇌척수액 분석의 증거Article Published on 2021-11-022022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, [키워드] Acidic Activation acute respiratory syndrome alteration Blood brain barrier cerebrospinal fluid coronavirus coronavirus 2 COVID-19 CSF CXCL13 Cytokine release syndrome Cytokine storm Cytokine storm syndrome cytokine-release syndrome dysfunction Encephalitis endothelial exhibited expressed GFAp healthy control ICANS IL-6 IL-8 Immune-mediated indicated Inflammatory Inflammatory biomarker investigated marker mechanism mechanisms myeloid cell Necrosis neurological manifestation neuronal Patient polymerase chain Protein Real-time PCR recent Release respiratory SARS-CoV-2 SARS-COV-2 infection Severe case severe cases soluble Triggering Receptor suggested TNF- α YKL-40 [DOI] 10.1093/cid/ciaa1933 PMC 바로가기 [Article Type] Article
Evaluation of Macular Retinal Vessels and Histological Changes in Two Cases of COVID-19Article Published on 2021-10-262022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 ACE2 receptor Acidic Activation alteration Analysis analyzed angiotensin-converting enzyme 2 change changes in collagen confocal microscopy COVID-19 Endothelial cell Endothelium expression GFAp histological immunofluorescence immunological increase in lectin Macula Macular microglia microglial morphology positive Post-mortem processed Protein quantified receptor Retina Retinal SARS-CoV-2 SARS-COV-2 infection subsequent suggested tissue tortuosity Vascular vasculature vessel [DOI] 10.3390/biomedicines9111546 PMC 바로가기 [Article Type] Article
Biomarkers for central nervous system injury in cerebrospinal fluid are elevated in COVID-19 and associated with neurological symptoms and disease severity뇌척수액의 중추신경계 손상에 대한 바이오마커는 COVID-19에서 상승하고 신경학적 증상 및 질병 중증도와 관련이 있습니다Article Published on 2021-10-012022-09-11 Journal: European journal of neurology [Category] MERS, SARS, 바이오마커, 진단, [키워드] Acidic Altered mental status Analysis autoantibody Biomarker Biomarkers Central nervous system cerebrospinal fluid CNS consciousness coronavirus disease Coronavirus disease 2019 correlated COVID-19 Critical CSF demonstrated disease severity elevated examined Extensive feature GFAp headache hospitalized patient hospitalized patients Immunoglobulin Immunoglobulin G Increased Injury intensive care level of consciousness light chain Mild neurological neurological manifestation neurological manifestations Neurological symptom Neurological symptoms NfL pathological finding pathological findings pathology Patient patients patients with COVID-19 plasma pleocytosis Protein reported SARS-CoV-2 small sample size total tau. Two patient two patients was performed weakness [DOI] 10.1111/ene.14703 PMC 바로가기 [Article Type] Article
Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up급성 COVID-19에서 성상세포 및 신경세포 손상의 신경화학적 징후는 장기 추적 관찰 중에 정상화됩니다Research Paper Published on 2021-07-292022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 바이오마커, 진단, [키워드] accompanied Acidic acute COVID-19 acute phase analysed association Biomarker Biomarkers blood sample Blood samples changes in Clinical research CNS Cognition collected Concentration Control controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 determine disease severity fatigue feature finding Follow-up foundation funding GDF-15 GFAp group growth indicate individual individuals Injury IQR Knut Long-term follow-up manifestation median Mild moderate moderate disease Neurochemical neurologic neurological Neurological symptom Neurological symptoms neuronal NfL no correlation normalization normalized Patient plasma biomarker plasma concentration plasma concentrations Protein provided reported SARS-CoV-2 severe COVID-19 significantly increased state Swedish the disease were recorded [DOI] 10.1016/j.ebiom.2021.103512 PMC 바로가기 [Article Type] Research Paper
Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective studyCOVID-19 환자의 중대 질환 다발신경병증, 근육병증 및 신경 바이오마커: 전향적 연구Observational Study Published on 2021-07-012022-09-11 Journal: Clinical neurophysiology : official journal of the [Category] MERS, 바이오마커, 임상, 진단, [키워드] Acidic Adult patients amplitudes Biomarker Characteristics cohort study coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness Critical illness neuropathy Critical illness polyneuropathy develop early phase feature GFAp had more ICU ICU care ICU patient ICU Patients intensive care intensive care unit invasive ventilation light chain Myopathy neurofilament neuronal Neuropathy NfL Non-COVID-19 non-COVID-19 cohort Patient plasma biomarker Polyneuropathy Predictive prevalent Prospective Study Protein SARS-CoV-2 significantly higher thromboembolic Thromboembolic event treated Uppsala Uppsala University weakness [DOI] 10.1016/j.clinph.2021.03.016 PMC 바로가기 [Article Type] Observational Study
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19입원 시 혈액 신경섬유 광 농도: COVID-19의 잠재적인 예후 마커Original Communication Published on 2021-03-202022-09-10 Journal: Journal of Neurology [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Acidic adjusted analyses Adjusted analysis Admission Analysis analyzed Biomarker Biomarkers Blood blood sample Blood samples clinical outcomes Clinical signs CNS Concentration COVID-19 COVID-19 patient COVID-19 patients detect discharged disease severity Effects GFAp Glial fibrillary acidic protein hypothese hypotheses Increased increased mortality Inflammatory biomarker inflammatory biomarkers Injury Inpatient intensive care intensive care unit light chain Linear model linear models measurement MONITOR Mortality nervous system Neurofilament light non-survivor Non-survivors objective on admission overall mortality Patient Prognostic marker Protein repeated Result risk SARS-CoV-2 serum serum biomarker serum biomarkers serum concentrations significantly higher Simoa subgroups survivor Symptoms the patient [DOI] 10.1007/s00415-021-10517-6 PMC 바로가기 [Article Type] Original Communication
LncRNA KCNA2-AS regulates spinal astrocyte activation through STAT3 to affect postherpetic neuralgiaResearch Article Published on 2020-11-232024-09-02 Journal: Molecular Medicine [Category] 대상포진, [키워드] GFAp LncRNA KCNA2-AS Postherpetic neuralgia pSTAT3 Spinal astrocytes [DOI] 10.1186/s10020-020-00232-9 PMC 바로가기 [Article Type] Research Article