Colonic expression of Ace2 , the SARS-CoV-2 entry receptor, is suppressed by commensal human microbiotaArticle Commentary Published on 2021-10-102022-10-31 Journal: Gut Microbes [Category] COVID-19, [키워드] association bowel colonic coronavirus COVID-19 pandemic Dysbiosis Effect entry receptor enzyme expressed expression germ-free mice GI Tract healthy highlight humanized IBS Infection intestinal investigated mechanism microbial microbiota Patient receptor Regulation responsible SARS-CoV-2 significantly suppressed syndrome the SARS-CoV-2 [DOI] 10.1080/19490976.2021.1984105 PMC 바로가기 [Article Type] Article Commentary
Physical Activity Reduction and the Worsening of Gastrointestinal Health Status during the Second COVID-19 Home Confinement in Southern ItalyArticle Published on 2021-09-102022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] 95%CI activity Apulia association Calabria Campania change Christma consequence COVID-19 COVID-19 pandemic Diseases Energy expenditure females Gastrointestinal gastrointestinal tract GI symptoms GI Tract Government Health Health status healthy individuals healthy subject home increase in Italian Italy offered physical activity reduce reduced scale second severity statistical significance statistically significant status subject subjects Support survey platform Symptoms total score WhatsApp worsening [DOI] 10.3390/ijerph18189554 PMC 바로가기 [Article Type] Article
What GI Physicians Need to Know During COVID-19 PandemicCOVID-19 팬데믹 동안 소화기 의사가 알아야 할 사항Review Published on 2021-09-012022-09-11 Journal: Digestive diseases and sciences [Category] SARS, 치료기술, [키워드] abnormality ACE-2 receptor anorexia appear caused cell line clearance confounding factor COVID-19 detected in stool diarrhea elevated enzyme Evidence General population GI symptom GI symptoms GI Tract host cells hypoxia infection rate infection rates involved liver Liver disease liver enzyme liver enzymes Liver manifestations: GI symptoms Loss of Smell management medications Mild morbidity and mortality Mortality nausea Patient patients patients with COVID-19 pharyngeal physician proportion recommendation Respiratory illness RNA SARS-CoV-2 Sepsis severe disease Severity of disease Stool Transmission Viral RNA virus vomiting worldwide pandemic [DOI] 10.1007/s10620-020-06625-4 PMC 바로가기 [Article Type] Review
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cellsResource and Technical Advance Published on 2021-08-232022-10-30 Journal: JCI Insight [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression AIDS/HIV analyzed antiviral genes antiviral response canonical cause change chronic controls COVID-19 disease severity downregulation Enterocyte epithelial cell expression fatality GI Tract Gut highest HIV infection homeostasis impair increased risk individual individuals infect Innate immunity interferon response interferon signaling intestinal lymphoid mucosal Prevent Protein reduction SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 receptor single-cell small intestine Symptoms target cell target cells tissue TMPRSS2 TMPRSS4 transcriptional profile treated uninfected upregulation vaccine response [DOI] 10.1172/jci.insight.148920 PMC 바로가기 [Article Type] Resource and Technical Advance
The eyes see what the mind seeks: a systematic review of abdominal imaging findings in patients with COVID-19Systematic Review Published on 2021-08-012022-10-27 Journal: The British Journal of Radiology [Category] COVID-19, MERS, [키워드] advance association bowel Coronavirus disease-19 COVID-19 database described distribution Evidence eye feature Final GI symptoms GI Tract Google Ground glass opacity help hepatic steatosis highlight imaging imaging abnormality increasingly Infarction Ischemia lung majority manifestation Manifestations nine organ Other pandemic pathophysiology Patient patients with COVID-19 positive predominant Prospective Study provide reported Research systematic literature search systematic review the disease the SARS-CoV-2 thrombosis Transmission vasculature was performed World Health Organization [DOI] 10.1259/bjr.20201220 PMC 바로가기 [Article Type] Systematic Review
Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier어린이의 다기관 염증 증후군은 장 점막 장벽의 조눌린 의존성 상실에 의해 유발됩니다Article Published on 2021-07-152022-09-11 Journal: The Journal of Clinical Investigation [Category] Coronavirus, SARS, 바이오마커, 치료기술, 치료제, [키워드] acute COVID-19 analyzed Antigen antigen detection antigenemia Biomarker biospecimen biospecimens bloodstream breakdown Cardiac complications characterized children children with MIS-C Clinical improvement controls COVID-19 decrease develop diagnosing disease driven by examined Gastrointestinal GI Tract Gut hyperinflammation Hyperinflammatory immune response immune responses increasingly Inflammation Inflammatory Inflammatory marker inflammatory markers intestinal permeability junctions larazotide life-threatening marker mechanistic data MIS-C mucosal mucosal barrier Pathogenesis Patient plasma probe proof proof of concept reverse transcription PCR RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 spike antigen stools subsequent Symptom syndrome target targets the patient tight junctions treated was used were assessed [DOI] 10.1172/JCI149633 PMC 바로가기 [Article Type] Article
Hypopharyngeal Ulcers in COVID-19: Histopathological and Virological Analyses – A Case ReportCOVID-19의 하인두 궤양: 조직병리학적 및 바이러스학적 분석 – 사례 보고서Case Reports Published on 2021-07-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Analysis Autopsy bowel can not CD68 cells Cells expressing composed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients demonstrated DNA esophagus excluded FIBRIN foci gastrointestinal tract GI Tract Hemorrhagic herpes simplex herpes simplex virus Herpes Simplex Virus 1 Histopathologic analysis histopathological Histopathology HSV HSV-1 hypopharynx immunohistochemistry infiltration Inflammation Inflammatory involved lesion Local microthrombi molecular molecular analysis mucosal mucosal injury muscle fibers Necrosis negativity oral cavity oropharynx Perspective pharyngeal Platelet positive cells posterior walls producing question report reported respiratory RNA SARS-CoV-2 SARS-CoV-2 spike Severe acute respiratory syndrome Skeletal muscle stomach subunit supported ulcer ulcerative ulcerative lesions virus viruses [DOI] 10.3389/fimmu.2021.676828 PMC 바로가기 [Article Type] Case Reports
A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 DeficiencyPharmacology Published on 2021-06-112022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor addition angiotensin-converting enzyme 2 binding blood pressure clinical trial Comorbidity component contribute COVID-19 COVID-19 pathology Critical deficiency diabete disease dysregulation Effect Effects Endocrine Evidence expressed function functions Gastrointestinal infection gastrointestinal problem GI Tract Gut hypertension increasingly inhibitor involved Kidney disease Local lung microbiota Mortality Multiorgan obesity organ-specific RAAS RAAS inhibitors receptor Regulation respiratory tract respiratory virus SARS-CoV-2 severity Therapeutic approach tissue while [DOI] 10.3389/fphar.2021.684610 PMC 바로가기 [Article Type] Pharmacology
Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms위장 증상이 있는 환자의 SARS-CoV-2 감염 및 COVID-19 결과에 대한 장 숙주 반응Multicenter Study Published on 2021-06-012022-09-11 Journal: Gastroenterology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] absence age analyses Analysis circulation Clinical significance Cohort comorbid conditions comparable COVID-19 COVID-19 case CXCL2 CXCL8 Cytometry dendritic cell dendritic cells disease severity down-regulation electron microscopy epithelial cells Europe examined Frequency Gastrointestinal GI infection GI symptom GI symptoms GI tissue GI tissues GI Tract highlight Hospitalization hospitalized patient hospitalized patients Host Host immune response Human IFNg IL1B illness immune immunofluorescence immunofluorescence staining independent independent of individual individuals infection with SARS-CoV-2 Inflammation inflammatory gene inflammatory genes inflammatory protein inflammatory proteins intestinal intestinal biopsy intestinal epithelial cell investigated logistic regressions microscopic examination Microscopy Mortality nasopharyngeal outcomes Pathogenesis Patient patients with COVID-19 presenting proinflammatory Proinflammatory response reduced reduction in response RNA sequencing SARS-CoV-2 SARS-CoV-2 viral loads Sex staining Symptom the United State These data tissue uninfected control United States Viral was reduced [DOI] 10.1053/j.gastro.2021.02.056 PMC 바로가기 [Article Type] Multicenter Study
Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders2형 면역 및 연령은 호산구성 위장 장애에서 코로나바이러스 유발 질병 2019 수용체의 유전자 발현을 수정합니다Article Published on 2021-05-012022-09-11 Journal: Journal of pediatric gastroenterology and nutritio [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus age airway analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 atopic caused children Coronavirus-2 COVID-19 datasets decreased expression disease disorder Effect enzyme Eosinophilic eosinophilic gastritis esophagitis expression gastritis Gastrointestinal gastrointestinal tract Gene Expression GI Tract host cell host cells Immunity Infection Inflammation Inflammatory inflammatory condition inflammatory conditions no difference pediatric portal Protective RNA-sequencing SARS-CoV-2 Serine serine protease serine protease TMPRSS2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significantly lower tissue TMPRSS2 Type viral entry [DOI] 10.1097/MPG.0000000000003032 PMC 바로가기 [Article Type] Article