Autoantibodies – enemies, and/or potential allies?Article Published on 2022-10-192022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] antibody Antigen autoantibodies autoantibody Autoimmune Autoimmune disease Autoimmune diseases binding Biomarker Cancer caused COVID COVID - 19 COVID-19 Diagnosis diagnostics disease Disease diagnosis disease-associated global pandemic Host include positive predict Prognosis self-antigens stability Symptom therapy Treatment Treatment. [DOI] 10.3389/fimmu.2022.953726 PMC 바로가기
ATP enhances the error-prone ribonucleotide incorporation by the SARS-CoV-2 RNA polymeraseArticle Published on 2022-10-152022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Analysis ATP biochemical caused Concentration conserved contribute coronavirus 2 COVID-19 COVID-19 patients develop effective ENhance function Genome global pandemic in vitro inhibitors intrinsic nucleotide nucleotides outbreak physiological Proofreading provided replicated replication-transcription complex respiratory reveal ribonucleotide RNA RNA polymerase RNA proofreading RNA replication-Transcription complex RNA-dependent RNA polymerase robust RTC SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2. specificity Structure the SARS-CoV-2 therapeutic strategy treated [DOI] 10.1016/j.bbrc.2022.07.087 PMC 바로가기
Deep Transfer Learning for COVID-19 Detection and Lesion Recognition Using Chest CT ImagesArticle Published on 2022-10-152022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy addition AUC automated can be used caused Chest CT image Chest CT images Chest CT scans CNN Complete Computed tomography coronavirus disease COVID-19 COVID-19 diagnosis CT-scan datasets death deep deep learning detection diagnose Diagnosis Diagnostic method false discovery rate FDR global pandemic heatmap highlight identify Image IMPROVE introduced learning lesion plague radiologist Recognition sensitivity shown specificity starting time-consuming transformer [DOI] 10.1155/2022/4509394 PMC 바로가기
Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell linesArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] Activation affected antibody binding cell line cell types Colon contribute COVID-19 COVID-19 patients described disease epithelial expression galectin-3 global pandemic identify IL-6 IL-6 expression inflammatory cells Intervention lung epithelial marker monoclonal antibody pathophysiology pro-inflammatory cytokine Protein receptor Research SARS-CoV-2 severe cases severe COVID-19 patients severe disease severity stimulate stimulated susceptible cell the cytokine storm therapeutic targets Treatment was reduced [DOI] 10.1038/s41598-022-20852-x PMC 바로가기
In-person training on COVID-19 case management and infection prevention and control: Evaluation of healthcare professionals in BangladeshArticle Published on 2022-10-042022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI age average Care collected conducted Consequences covariate COVID-19 COVID-19 case COVID-19 illness COVID-19 pandemic enrolled Factor global pandemic Government group HCW Health healthcare Healthcare professional Healthcare system healthcare worker help hospital Infection prevention knowledge less management morbidity Nurses organization pandemic Pandemics participant participated plan response SARS-COV-2 infection Sex shown variants with COVID-19 [DOI] 10.1371/journal.pone.0273809 PMC 바로가기
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proof-of-Concept Model Development for RemdesivirArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerate Administered antibody approach calibrated calibration clinical Clinical data Clinical outcome clinical setting clinical study Clinical trial design coronavirus disease Course COVID-19 COVID-19 disease COVID-19 therapeutics Cytokines development disease drug candidate example global pandemic immune responses immunological in silico include intravenously lymphopenia metabolism metabolite Mild Model Patient pharmacological Pharmacology Placebo predict provide quantitative framework Remdesivir responses severe COVID-19 System the disease the primary endpoint Therapies therapy Time to recovery translate validation viral titer virus infection [DOI] 10.1002/cpt.2686 PMC 바로가기
Molecular aspects of Omicron, vaccine development, and recombinant strain XE: A review오미크론의 분자적 측면, 백신 개발 및 재조합 균주 XE: 검토Review Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] ACE2 affinity antibody resistance B.1.1.529 booster Booster vaccine COVID-19 CRISPR decrease dosage Efficiency elicited epidemiological Evolution feature genomic global pandemic Infection Mutation omicron Omicron variant Prevalence rate of infection RBD region recombinant variants reduce Research research and development several variant several variants South Africa specific mutations spike region strain T-cell immunity Transmission utilization Vaccine Vaccine development Vaccines variant variant of COVID-19. variant-specific vaccine variant-specific vaccines virus with COVID-19 [DOI] 10.1002/jmv.27936 PMC 바로가기 [Article Type] Review
Brequinar and dipyridamole in combination exhibits synergistic antiviral activity against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19Research article Published on 2022-10-012022-10-05 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] acute respiratory syndrome Antiviral antiviral activity Antiviral treatment B.1.351 B.1.617.2 Beta Brequinar cellular Combination coronavirus coronavirus disease COVID-19 de novo deaths Delta DHODH Dihydroorotate dehydrogenase (DHODH) Dipyridamole drug treatments effective enzyme evade Evolution of SARS-CoV-2 exhibit global pandemic Host host cell in vitro Infection infections inhibitor maintain medical need monoclonal antibody nucleotide pathway rationale Replication required resulting RNA virus SARS-CoV-2 SARS-COV-2 infection selective shown Support synergistic therapy treat Treatment Vaccine variants viral replication [DOI] 10.1016/j.antiviral.2022.105403 [Article Type] Research article
Human coronaviruses: The emergence of SARS-CoV-2 and management of COVID-19Review article Published on 2022-10-012022-10-05 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] acute respiratory syndrome circumvent coronavirus coronavirus disease COVID-19 Cross-species transmission deaths disease severity global pandemic Healthcare system highlight Human human coronavirus human coronaviruses implication Infection Long COVID management Mutation Respiratory pathogens SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seven Strains transmission of SARS-CoV-2 Treatment Vaccines variants of concern zoonotic transmission [DOI] 10.1016/j.virusres.2022.198882 [Article Type] Review article