Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90SARS-CoV-2 Orf9b의 인산화는 TOM70의 2개 결합 부위에 대한 표적화 및 Hsp90 모집을 조절합니다Article Published on 2021-08-262022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association B.1.1.7 binding binding site C-terminal domain cascade causative agent chaperone chaperones characterized complex coronavirus COVID19 decrease domain ENCODE expression Glutamate Hsp90 IFN-I indicate infected cells inhibit interferon interferons involved leads mechanism Mitochondria mitochondrial mitochondrial outer membrane N-terminal N-terminal domain Orf9b pandemic Phosphorylation position Protein Proteins recruitment reduced regulated respiratory SARS-CoV-2 SARS-CoV-2 genome Serine severe acute respiratory syndrome Coronavirus Signaling Site target targeting TOM70 TPR type I interferon type I interferons variant variant of concern Viral Viral protein [DOI] 10.3390/ijms22179233 PMC 바로가기 [Article Type] Article
Comprehensive investigation of RNA-sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndromeRNA 시퀀싱 데이터 세트에 대한 포괄적인 조사는 코로나바이러스 질병 2019 급성 호흡 곤란 증후군의 허브 유전자 및 분자 메커니즘을 보여줍니다Article Published on 2021-08-012022-09-11 Journal: IET systems biology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS ARDS patients CD4 Cell complement Comprehensive comprehensive analysis control group coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 ARDS patient cytokine dataset DEGs differentially expressed gene Differentially expressed genes drug eosinophil eosinophils follicular Functional enrichment analysis G-protein Glutamate GSE163426 hub genes Immune cell infiltration infiltration involved Macrophage macrophages mechanism molecular mechanism molecular mechanisms network analysis pathway patients potential molecular receptor respiratory distress Respiratory distress syndrome reveal RNA sequencing RNA-sequencing significantly syndrome T cell T cells was obtained [DOI] 10.1049/syb2.12034 PMC 바로가기 [Article Type] Article
The oxygen dissociation curve of blood in COVID-19코로나19 혈액의 산소 해리 곡선Review Published on 2021-08-012022-09-11 Journal: American journal of physiology. Lung cellular and [Category] SARS, 치료기술, [키워드] affinity Anemia ATP Blood blood sampling calculated caused Cell change Concentration contrary COVID-19 dissociation curve distribution equilibration erythropoietin Factors functional Glutamate glutathione half-saturation pressure hemoglobin hemoglobin oxygen affinity Hemolysis in vivo in vivo oxygen dissociation curve increase interstitial fluid Lactate lung Lungs methemoglobin Methylene Methylene blue oxygen oxygen affinity oxygen dissociation reduce reduced reduction saturation saturation pressure therapy tissue tissues Transport Volume [DOI] 10.1152/ajplung.00079.2021 PMC 바로가기 [Article Type] Review
Kynurenic acid may underlie sex-specific immune responses to COVID-19Research Resource Published on 2021-07-062022-10-28 Journal: Science Signaling [Category] COVID-19, SARS, [키워드] Activation age Analysis chemokine Clinical outcome clinically Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cytokine abundance disease enzyme examined expression female females gene encoding Glutamate Health care worker immune response immune responses individuals Inflammation Inflammatory cytokine inhibit Kynurenic acid male Male sex males metabolism metabolite metabolites metabolome metabolomics Mortality Older outcome Patient patients performed positive positively correlated regulated reveal risk factor SARS-COV-2 infection serum T cell responses the disease underlie uninfected was reduced [DOI] 10.1126/scisignal.abf8483 PMC 바로가기 [Article Type] Research Resource
Incomplete Systemic Recovery and Metabolic Phenoreversion in Post-Acute-Phase Nonhospitalized COVID-19 Patients: Implications for Assessment of Post-Acute COVID-19 Syndrome급성기 비입원 COVID-19 환자의 불완전한 전신 회복 및 대사성 표현 전환: Post-Acute COVID-19 증후군 평가에 대한 시사점Article Published on 2021-06-042022-09-11 Journal: Journal of Proteome Research [Category] SARS, 치료기술, [키워드] acute COVID-19 acute respiratory syndrome adaptive amino acids Analysis analyzed Anosmia approach assessment Asymptomatic biochemical Biomarker Biomarkers blood sample Blood samples Chronic fatigue Control controls Correlation analysis cough COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients discriminant analysis Dyspnea elevated exhibiting Follow-up functional Functional assessment Glutamate Glutamine Glycoproteins greater healthy control healthy controls Hospitalized immune immune function in some Incomplete Infection joint joint pain Kynurenine Lipoproteins liver long-COVID long-COVID syndrome mass spectrometry metabolic Metabolic data metabolites Multiorgan multiorgan disease multiple parameter multiple parameters myalgia NMR nuclear magnetic resonance Other Pain parameter pathophysiology pathway Patient patients PCA phenoconversion phenoreversion phenotype plasma plasma samples Post-acute COVID-19 syndrome Principal component principal component analysis reduced reduction in remained resonance respiratory-related symptom respiratory-related symptoms rhinorrhea SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patient Severe acute respiratory syndrome Significant significantly significantly lower Spectrum Symptom symptomatic symptomatic patient Symptomatic patients syndrome systemic systemic inflammatory Taurine the healthy the patient tissue repair Tryptophan was normalized [DOI] 10.1021/acs.jproteome.1c00224 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cellsResearch Article Published on 2021-05-282022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] 1H-NMR Acetate acute respiratory distress ARDS autologous CD8 CD8+ T cells change characterized convalescent COVID-19 patients convalescent patient Convalescent patients COVID-19 Cytometry cytotoxic function elevated expression Flow flow cytometry Glutamate granzyme Granzyme A Immune cell immune cells immune response infectious disease outbreak interfere investigated Lactate metabolic function metabolites Mild moderate Moderate COVID-19 mononuclear cell Patient patients PBMCs perforin Peripheral blood SARS-COV-2 infection SARS-CoV-2 virus significantly suggested syndrome T cell T cells Taurine virus [DOI] 10.1016/j.heliyon.2021.e07147 PMC 바로가기 [Article Type] Research Article
Study protocol for a phase II randomised, double-blind, placebo-controlled trial of perampanel as an antiepileptogenic treatment following acute stroke급성 뇌졸중 후 항간질 치료제로서 페람파넬에 대한 2상 무작위, 이중 맹검, 위약 대조 시험을 위한 연구 프로토콜Article Published on 2021-05-102022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 adverse event adverse events analysed approved baseline Cognitive function collected Concentration correlation cortical double-blind dysregulation Efficacy and safety enrolled epilepsy Ethics ethics committee evaluate Evidence Fisher Fisher's exact test Glutamate high risk HREC Human include ischaemic stroke life lobar magnetic resonance imaging Magnetic resonance spectroscopy matching placebo mechanism of action medication mood MRI outcome outcomes participant Patient perampanel performed Placebo placebo-controlled trial plasma Primary prevention proportion protocol Quality quantification Questionnaires randomisation randomised receive reference registration number Research Ethics scale secondary Secondary outcomes Seizure Seizures stratified stroke stroke medicine study period Support titration transfer Treatment unique Withdrawal [DOI] 10.1136/bmjopen-2020-043488 PMC 바로가기 [Article Type] Article
Susceptibility of neuroblastoma and glioblastoma cell lines to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 신경모세포종 및 교모세포종 세포주의 감수성Article Published on 2021-05-012022-09-11 Journal: Brain research [Category] SARS, 치료기술, [키워드] Analysis Apoptosis Cell cell line cell lines cell type cells Coronavirus-2 CTSB CTSL Cytopathic effect death demonstrated described downregulation epithelial cell epithelial cells Express Gene Expression Genes Glioblastoma Glutamate idea In situ hybridization infected cell infected cells Infection maintain MOI MOIs Neuroblastoma neuronal neurotropism Perspective quantification replicate retinoic acid RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe acute respiratory coronavirus Severe acute respiratory coronavirus-2 SH-SY5Y susceptibility tropism upregulation Vero E6 VERO E6 cells virus were expressed were infected [DOI] 10.1016/j.brainres.2021.147344 PMC 바로가기 [Article Type] Article
Correlation of Low Levels of α -1 Antitrypsin and Elevation of Neutrophil to Lymphocyte Ratio with Higher Mortality in Severe COVID-19 Patients중증 COVID-19 환자에서 낮은 수준의 α-1 항트립신과 호중구 대 림프구 비율 상승과 사망률의 상관관계Observational Study Published on 2021-04-282022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] accounted Admission alterations antitrypsin arterial oxygen saturation blood count blood sugar C-reactive protein CBC Chain Reaction cohort study Comorbidities complete blood count COVID-19 COVID-19 illness COVID-19 patient CRP CRP level CRP values dysregulated immune response dysregulation Elevation erythrocyte sedimentation erythrocyte sedimentation rate ESR etiology explanation form Glutamate groups Hospitalization hospitalized patient hospitalized patients hyperinflammation immune dysregulation immune response immunomodulatory effect individual Individual differences inflammation response involved Level lymphocyte marker mechanism mortality rate MOST neutrophil NLR not significantly different O2sat Observational cohort study Oxaloacetate oxygen oxygen saturation patients PCR percentage percentages plasma protein polymerase chain polymerase chain reaction positive COVID-19 Prevalence pyruvate random Ratio RBC Result retrospective sedimentation rate serum Serum level severe COVID-19 severe COVID-19 illness severe COVID-19 patient severe COVID-19 patients severe forms of COVID-19 severe symptoms severity SGOT SGPT sugar the patient troponin troponin level troponin levels with COVID-19 [DOI] 10.1155/2021/5555619 PMC 바로가기 [Article Type] Observational Study
Novel Mechanism for Memantine in Attenuating Diabetic Neuropathic Pain in Mice via Downregulating the Spinal HMGB1/TRL4/NF-kB Inflammatory AxisArticle Published on 2021-04-012024-09-02 Journal: Pharmaceuticals [Category] 대상포진, [키워드] Glutamate HMGB1/TRL4/NF-kB axis Memantine mouse diabetic neuropathy sciatic pathology [DOI] 10.3390/ph14040307 PMC 바로가기 [Article Type] Article