MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granulesResearch Article Published on 2022-02-062022-10-28 Journal: Virulence [Category] COVID-19, [키워드] Act Actinomycin Analysis Antigen presentation Cell Cell migration cells cellular complex death downregulated downregulating explain Genes Granule impair Inflammatory inhibit LLPS Lysosomes mass spectrometry mechanism MERS-CoV MERS-CoV infection metabolic processe metabolic processes Middle East mRNA non-structural protein nsp1 oxidative phosphorylation P-bodies Protein Regulatory respiratory syndrome coronavirus ribosomal protein ribosome RNA sensitivity Sequencing shown stress granule stress granules transcriptional transgenic mice upregulated viability [DOI] 10.1080/21505594.2022.2032928 PMC 바로가기 [Article Type] Research Article
Lianhua Qingwen Capsules Reduced the Rate of Severity in Patients with COVID-19: A System Review and Meta-Analysis of Randomized Controlled TrialsReview Article Published on 2022-02-022022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] 95% CI 95%CI affecting analysis association Capsule Chinese Clinical efficacy conducted Controlled coronavirus disease COVID-19 Critical database Effect exclusion criteria Granule identify Inclusion Infectious disease Meta-analysis Mild moderate Moderate COVID-19 Mortality Patient Prognosis Randomized controlled trial Rate RCT RCTs reducing Result review searched Severe case severity supported System therapy treating COVID-19 Treatment [DOI] 10.1155/2022/9617429 PMC 바로가기 [Article Type] Review Article
COVID-19 Knowledge/Practices, Mental Status, and Return-To-Work Concerns Among Healthcare Workers in Huangzhou District, Huanggang City, ChinaPublic Health Published on 2022-01-142022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Adverse reaction alleviate Analysis Anxiety anxiety symptom anxiety symptoms asymptomatic infections China Chinese city Clinical efficacy concern concerning country COVID-19 cross-sectional District female form Good Granule HCW HCWs healthcare worker high risk hospital hospitals indicated investigated knowledge male Mild moderate participant preference Prevent preventative measures promotion protective factor psychological Impact Psychological state psychological support Public Hospital Quantitative recruit reduce Region reported required response Return to work risk factor risk of infection SAS Self-Rating Anxiety Scale significantly higher status TCM throat swab Traditional Chinese medicine treat Trial was used were used while worker [DOI] 10.3389/fpubh.2021.723118 PMC 바로가기 [Article Type] Public Health
Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling pathwayYindan Jiedu 과립은 NF-κB 신호 전달 경로를 억제하여 신종 코로나바이러스 감염증(COVID-19) 환자에서 항염증 효과를 나타냅니다.Randomized Controlled Trial Published on 2022-01-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] SARS, 유전자 메커니즘, 임상, [키워드] accompanied Activation acute lung injury amyloid A Analysis animals anti-inflammatory effect Anti-inflammatory effects assigned caused CD4 cells clinical Clinical research Compound compounds control group coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 progression Cytokines death decrease disease dissipation docking Effect enrichment analysis erythrocyte sedimentation erythrocyte sedimentation rate evaluate evaluated Factor Granule high-performance liquid chromatography histological HPLC IL-1β IL-6 immune in vitro increase in Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines inflammatory factors inhibit inhibiting Interaction IκBα kaempferol lesion Ligand ligands lipopolysaccharide lung Lung injury Luteolin mass spectrometry mechanism mechanism of action molecular docking Negative conversion network model NF-κB NF-κB pathway NF-κB signaling NF-κB signaling pathway nuclear translocation nucleic acid overlapping p65 pandemic participant pathway Patient Pharmacology Pharmacology analysis Phosphorylation progression propensity score matching PSM quercetin Randomly recruited sedimentation rate serum serum amyloid significantly strong interaction suppressed T cell Tandem mass spectrometry target targets therapeutic effect therapeutic effects TNF-α viral nucleic acid were measured Yindan jiedugranules. [DOI] 10.1016/j.phymed.2021.153784 PMC 바로가기 [Article Type] Randomized Controlled Trial
Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in HumansArticle Published on 2021-11-112022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] alteration anti-viral activity approach Brain candidate coronavirus COVID-19 COVID-19 infection DCTN1 disorder dissect drug DYNC1H1 enrichment analysis Granule Health host response Human identify impair innate immune insight involved LMNA Lung disease Manifestations microRNA miRNAs Mortality network performed Protein protein-protein interaction protein–protein interaction Proteins regulatory network SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein Signaling stress granule stress granule proteins translation Treatment viral replication [DOI] 10.3390/pathogens10111459 PMC 바로가기 [Article Type] Article
The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule FormationCellular Response to Infection Published on 2021-10-132022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] activate activated activating Activation acute respiratory syndrome addition antiviral drugs antiviral role Betacoronavirus cause caused Cell Characteristics coronavirus coronavirus Coronavirus replication coronavirus-infected cell coronavirus-infected cells Coronaviruses decrease disease Diseases double-stranded eIF2α eIF2α Encephalomyelitis Endoplasmic reticulum endoplasmic reticulum stress ER stress facilitate Facilitating Formation Granule high mortality rate Host Human in vitro in vivo infected cells Infection inhibited innate response Interaction interferon invading pathogen mechanism MERS-CoV Middle East modulate nerve cell neurotropic new treatment strategy Occurrence outcome pathogenic pathway Phosphorylation PKR porcine hemagglutinating encephalomyelitis virus promoted Protein protein translation regulate regulated Replication repressed respiratory syndrome coronavirus reveal SARS-CoV SARS-CoV-2 signaling pathway specific treatment stress granule suppressed target translation attenuation triggered turn unfolded protein response UPR viral proliferation viral replication virus [DOI] 10.1128/JVI.01695-21 PMC 바로가기 [Article Type] Cellular Response to Infection
Efficacy of Jinhua Qinggan Granules Combined With Western Medicine in the Treatment of Confirmed and Suspected COVID-19: A Randomized Controlled TrialMedicine Published on 2021-10-122022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] anti-infective drugs antiviral drug antiviral drugs China Chinese medicinal clinical Clinical efficacy clinical symptom Clinical symptoms clinical trial collected Combined Confirmed control group Controlled Controlled clinical trial coronavirus disease COVID-19 COVID-19 patient COVID-19 patients diarrhea disease Effect evaluate fatigue Fever Granule groups information Jinhua Qinggan granules Medicine Negative conversion rate no significant difference nucleic acid participated Patient patients Prognostic value Randomized Randomized controlled trial randomly divided reduce registry significantly lower Suspected suspected patient Symptom treated Treatment two groups use of antibiotics [DOI] 10.3389/fmed.2021.728055 PMC 바로가기 [Article Type] Medicine
Clinical and virological outcomes with baloxavir compared with oseltamivir in pediatric patients aged 6 to < 12 years with influenza: an open-label, randomized, active-controlled trial protocolStudy Protocol Published on 2021-08-092022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] administration all subject Antiviral treatment approved baloxavir baloxavir marboxil Child clinical Clinical trial protocol Complication conducted cough criteria demonstrated dose Efficacy and safety Endpoint Evidence Granule include Infection Influenza influenza infection influenza treatment Influenza virus inhibit intention-to-treat Japan Japanese median time Mild multicenter nasal Open-label oseltamivir outcome pediatric Pediatric patient primary analysis population Randomized Randomly receive registry safety population single dose study drug subject sustained Symptom Transmission Trial trial protocol virological outcome [DOI] 10.1186/s12879-021-06494-w PMC 바로가기 [Article Type] Study Protocol
Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patientsResearch article Published on 2021-08-012022-10-05 Journal: International immunopharmacology [Category] 바이오마커, [키워드] CD38 CD8 CD8 T cell cells characterisation chemokine contribute convalescent convalescent patient convalescent phase COVID-19 COVID-19 case COVID-19 pathogenesis COVID-19 patient Critical Critically ill Cytokines /chemokines deficiency dendritic cell dysregulation evidenced expressed flow cytometry Frequency Granule granzyme B Hospital admission Host host immune system IL-10 IL-6 ill patient Immune cell immunoassay Inflammatory Inflammatory response IP-10 MCP-1 MIG multiplex natural killer NK cells pandemic pathogenesis of COVID-19 Patient plasmacytoid DCs plasmacytoid dendritic cell potential therapeutic target profile proportion reached restored Result severe patients Severe/critical infection significantly higher subset was reduced with COVID-19 [DOI] 10.1016/j.intimp.2021.107685 [Article Type] Research article
Current status of traditional Chinese medicine for the treatment of COVID-19 in ChinaReview Published on 2021-07-272022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] acute respiratory syndrome antiviral drug caused Characteristics China Chinese clinical Clinical characteristics clinical manifestation Clinical symptoms Clinical treatment commenced coronavirus disease COVID-19 current determine drug early stage feature genome sequence Granule H1N1 immunoassay include influenza pandemic injection nucleic acid amplification outbreak Pneumonia Practitioner presenting Protein Respiratory Coronavirus SARS-CoV-2 severe respiratory illness TCM the antibody the disease Traditional Chinese medicine treat Treatment Trial virus was used [DOI] 10.1186/s13020-021-00461-y PMC 바로가기 [Article Type] Review