Use of Thiols in the Treatment of COVID-19: Current EvidenceReview: Use of Thiols in Treatment of Covid-19 Published on 2021-08-272022-10-31 Journal: Lung [Category] COVID-19, MERS, SARS, [키워드] alveolar damage anti-inflammatory properties antioxidant Bacteria Blood Cell Characteristics characterized complex coronavirus disease COVID-19 COVID-19 pneumonia patient current death in COVID-19 deficiency distress drug drugs dysregulation effective Erdosteine free radical GSH Infection Influenza virus intravenous manifestation N-acetylcysteine NAC NF-kB oral oxidative stress patients pharmacological precursor reactive oxygen specy responsible ROS syndrome the cytokine storm Therapeutic approach thiol thrombosis Treatment variety [DOI] 10.1007/s00408-021-00465-3 PMC 바로가기 [Article Type] Review: Use of Thiols in Treatment of Covid-19
SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathioneResearch Paper Published on 2021-06-102022-10-28 Journal: Redox Biology [Category] COVID-19, MERS, SARS, [키워드] Abstract Activation alteration Analysis Antiviral antiviral drug antiviral potency Cell cellular change COVID-19 CPE Cytopathic effect demonstrated ER stress expression data generate glutathione GSH GSSG homeostatic host cell hpi Image impair in vitro in vitro model in vitro study Increased infected cells Infection investigated marker membrane transporter metabolism NAC nelfinavir Nrf2 occurred oxidized glutathione precursor Prevent produced Protein Protein glutathionylation Proteins reduced Replication reported SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection Schematic thiol Thiols transcription factor Treatment upregulation VERO E6 cells viral replication virus [DOI] 10.1016/j.redox.2021.102041 PMC 바로가기 [Article Type] Research Paper
The Impact of Diet on the Involvement of Non-Coding RNAs, Extracellular Vesicles, and Gut Microbiome-Virome in Colorectal Cancer Initiation and ProgressionReview Published on 2020-12-142023-08-30 Journal: Frontiers in Oncology [Category] E형 간염, [키워드] cancer prevention Colorectal cancer diet Extracellular vesicles GSH MGMT Microbiome ncRNAs [DOI] 10.3389/fonc.2020.583372 PMC 바로가기 [Article Type] Review
Centrality of G6PD in COVID-19: The Biochemical Rationale and Clinical ImplicationsMedicine Published on 2020-10-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Achille aldosterone (Ald) Analysis antimalarial antioxidant Asymptomatic biochemical biochemical pathway Biomarker clinical Clinical data clinical manifestation clinical observations Cohort Course COVID-19 COVID-19 pathogenesis Critical dataset Defense deficiency develop disease epidemiological Europe explain Fact G6PD Glucose-6-phosphate glucose-6-phosphate dehydrogenase (g6pd) glutathione GSH health condition immune response increase Inflammatory investigated manifestation mechanism metabolic syndrome MONITOR mortality rate nitric oxide nitric oxide - NO observation pathway Patient PMC RAAS rationale reactive oxygen species reactive oxygen specy ROS SARS-CoV-2 syndrome Treatment Trigger unique were used [DOI] 10.3389/fmed.2020.584112 PMC 바로가기 [Article Type] Medicine
Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness?Pharmacology Published on 2020-10-072022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 airway angiotensin-converting enzyme 2 anti-inflammatory drug antioxidant Antiviral authority bacterial superinfection cells COVID-19 COVID-19 pandemic COVID-19 patient depleting disease symptoms drug early phase effort Fever glutathione GSH Hospitalized Host Hypothesis increased risk Inflammation management medication Non-steroidal anti-inflammatory drugs NSAID NSAIDS oxidative damage Pain Paracetamol question raise raised receptor Research Risk factors SARS-CoV2 severely ill patients Symptoms the disease treat Treatment viral infection viral infections [DOI] 10.3389/fphar.2020.579944 PMC 바로가기 [Article Type] Pharmacology
Glutathione Supplementation as an Adjunctive Therapy in COVID-19Review Published on 2020-09-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] caused coronavirus disease COVID-19 COVID-19 patients Cytokine storm Cytokines decrease dysregulated Effect Epidemiology Evidence glutathione GSH HIV Human immunodeficiency virus hypercoagulable IFN-α IFN-β IL-6 immune response inhibit interferon Mortality multi-organ failure Necrosis oxidative stress Pathogenesis patients pulmonary disease the disease TNF-α TNF-α Transmission Treatment Tuberculosis viral replication [DOI] 10.3390/antiox9100914 PMC 바로가기 [Article Type] Review
Synthesis of N , N ′-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide that ameliorate osteoarthritis symptoms and improve bone marrow matrix structure and cartilage alterations induced by monoiodoacetate in the rat model: “Suggested potent anti-inflammatory agent against COVID-19”Articles Published on 2020-08-252022-10-31 Journal: Human & Experimental Toxicology [Category] Coronavirus, [키워드] activity addition Alpha alteration animal model Anti-inflammatory anti-inflammatory agent antioxidant enzymes ATP biological activity Blood blood corpuscle Bone marrow C-reactive protein cartilage chloride complex COVID-19 cytochrome c oxidase declining effective elevated Factors Gene Expression GSH histological IL-6 IMPROVE Infection Inflammation male marker membrane mitochondrial Mitochondrial function mitochondrial potential myeloperoxidase Necrosis Osteoarthritis parameters pathophysiological Randomly reactive oxygen species screened serum Severe infection significant effect Symptom synthesis three group TNF-a Transmission treated with COVID-19 xanthine [DOI] 10.1177/0960327120945779 PMC 바로가기 [Article Type] Articles
The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19Review Published on 2020-07-162022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] acute respiratory distress affecting angiotensin-converting enzyme (ACE) Angiotensin-converting enzyme 2 (ACE2) appear Asymptomatic biochemical Chloroquine clinically competing condition COVID-19 COVID-19 pandemic Critical Cytokine storm described diabete Drawing event Evidence exacerbated feasibility glutathione glycine GSH highlight homeostasis hypertension Inflammation many case mechanism Mild N-acetylcysteine Organ failure Paracetamol pathway Patient Prevent progression PROTECT Protecting provide reactive oxygen specy reduced response responsible role ROS SARS-CoV-2 severe COVID-19 severe disease severe symptom subject syndrome the disease tissues Trigger virus with COVID-19 [DOI] 10.3390/antiox9070624 PMC 바로가기 [Article Type] Review
A novel chitosan based antimalarial drug delivery against Plasmodium berghei infectionarticle Published on 2013-12-312024-09-01 Journal: Family process [Category] 말라리아, [키워드] 5′5′-dithio(bis)-2-nitrobenzoic acid anti-malarial drug C-reactive proteinase chitosan Chloroquine CQ CRP DTNB EDTA ethylene diamine tetra acetate FACS fluorescence activated cell sorter glutathione reductase GR GSH GSSG H(2)O(2) hydrogen peroxide IC infected control lactate dehydrogenase LDH Lymphocytes malaria malondialdehyde MDA NADPH Nanochloroquine NCQ Nicotinamide adenine dinucleotide phosphate O-diamisidine OPD oxidized glutathione PBS Phosphate buffer saline Plasmodium berghei reactive oxygen species reduced glutathione ROS serum glutamate oxalate transaminase serum glutamate pyruvate transaminase SGOT SGPT TBA TBARS TCA thiobutiric acid thiobutiric acid reactive substance trichloro acetic acid [Article Type] article