The Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory PandemicReview Published on 2021-11-152022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] “cytokine storm” affected alveolar edema characterized clinical Clinical outcome Clinical severity Complication COVID-19 Cytokine storm determine disorder H1N1 H1N1 influenza Hemostasis Human hypoxia immune dysregulation immune response involved mechanism MERS Multiorgan dysfunction Pandemics Pathogenesis Potential respiratory Respiratory disease respiratory diseases respiratory viral Respiratory virus infections role SARS Spanish flu storm Symptoms systemic inflammation the cytokine storm triggered [DOI] 10.3390/biomedicines9111688 PMC 바로가기 [Article Type] Review
Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamicsResearch Article Published on 2021-10-252022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis antiviral response Cell Cell culture coefficients condition coronavirus COVID-19 cultures cytokine cytokine signaling Cytokine storm diffusion drug candidates early stage epithelial evaluated evidenced excessive inflammation exhibit experiment Factor flu form growth H1N1 influenza H3N2 help highlight immune immune response immunopathology IMPROVE in some in vitro include induce Infection inflammatory condition Inflammatory response Influenza inhibit innate immune response interferon interferon response interferon signaling interferons involved JAK/STAT pathway lesion linear local concentration lung lung cell Lung epithelial cells Lung infection Lungs manifestation mechanism molecular multicellular Occurrence pandemic Pandemics parameter pathway performed plaque plaques protective effect public health radial growth Replication respiratory Respiratory disease respiratory infection responsible reveal RNA virus RNA viruses SARS-CoV-2 severe cases severe inflammation severity Signaling signaling molecule Spanish the disease tissue Treatment Trigger type I interferons understanding Variation viral growth Viral load viral replication virus virus-infected cell [DOI] 10.1371/journal.pcbi.1008874 PMC 바로가기 [Article Type] Research Article
Fulminant H1N1 and severe acute respiratory syndrome coronavirus-2 infections with a 4-year interval without an identifiable underlying cause: a case report전격성 H1N1 및 중증급성호흡기증후군 코로나바이러스-2 감염, 4년 간격으로 뚜렷한 근본 원인 없이: 증례 보고Case Reports Published on 2021-10-082022-09-10 Journal: Journal of Medical Case Reports [Category] MERS, SARS, 변종, 신종인플루엔자, [키워드] acute kidney acute respiratory syndrome Admission age Analysis Antiviral asymptomatic infection autoantibody Case report challenge clinical picture clinical recovery Comorbidity contributing to Coronavirus-2 Course COVID-19 demonstrated disease disease-causing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Exome expression Factor fulminant genetic change Genetic changes genetic defect genetic defects Genetic variant genetic variants H1N1 H1N1 influenza healthy ICU immune immunological impairment indicate Infection infections Influenza intensive care intensive care unit admission interferon Interferon (INF) interferon pathway interferon response interferon-stimulated gene mechanical ventilation mononuclear cell mononuclear cells Pathways Patient Peripheral blood Perturbation reduced respiratory risk factor Risk factors SARS-CoV-2 Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity suffered susceptibility the interferon the patient triggered type I Variation Viral viral infection viral infections virus infection [DOI] 10.1186/s13256-021-03113-9 PMC 바로가기 [Article Type] Case Reports
Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset증상 발병 전 인플루엔자 및 감기를 감지하기 위해 비침습적 웨어러블 생체 모니터링 센서를 사용하는 것의 타당성 평가Research Published on 2021-09-292022-09-25 Journal: JAMA Network Open [Category] Fulltext, 신종인플루엔자, 임상, 진단, [키워드] 24 hour Accuracy age Analysis assessment AUC Can characteristic chronic respiratory Cohort cohort study Cold collected common conducted Contagion COVID-19 criteria Culture detect evaluate exposure feasibility feasible finding General population H1N1 H1N1 influenza help Human rhinovirus identify Importance individual Infection infectious dose Influenza inoculated Intervention intranasal limit measure men Mild moderate monitoring noninvasive objective Onset participant Patient Performance metrics Point Precision predict presymptomatic prevent disease spread primary outcome measure random recruited Relevance resource respiratory virus Result rhinovirus screening method sensitivity sensor Separate serum antibodies setting severity specificity Spread strain type Support Symptom symptom onset TCID50 the median tissue took place trajectory viral challenge viral infection viral respiratory infection viral respiratory infections virus [DOI] 10.1001/jamanetworkopen.2021.28534 PMC 바로가기 [Article Type] Research
The Relationship Between COVID-19 Infection Rates and Social Determinants of Health in Broward and Miami-Dade Counties, FloridaInternal Medicine Published on 2021-08-282022-10-31 Journal: Cureus [Category] COVID-19, [키워드] adjusted African American age Akaike information criterion association black census Combination coronavirus COVID-19 COVID-19 case death Department determinant determine evaluated example explained female Florida Gender H1N1 influenza Health highest Hispanic increased risk independent variable individual investigator Latino male management MathWorks MATLAB median age Natick objective other variables outcomes pandemic Pandemics per capita income predicted predictor predictors race inequities Rate Regression regression analysis relationship Result Retrospective cross-sectional study SARS-CoV scaled Sex socio-economic factors South statistically significant tested The United States USA used data variable variables was performed was selected [DOI] 10.7759/cureus.17524 PMC 바로가기 [Article Type] Internal Medicine
Disability-Adjusted Life Years for the COVID-19 Pandemic in the Mexican PopulationPublic Health Published on 2021-08-172022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] affected age all age group caused causes confirmed case country COVID-19 COVID-19 case COVID-19 disease DALYs died disease global burden of disease H1N1 influenza highest Impact individual information life México median age men Ministry of Health pandemic Population Registered released reported risk of death SARS-CoV-2 the disease Year YLDs YLLs [DOI] 10.3389/fpubh.2021.686700 PMC 바로가기 [Article Type] Public Health
The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of InfectionsReview Published on 2021-07-232022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] arising B.1.1.7 CCL2 changes in clinical Clinical treatment clinical trial clotting factor community transmission convalescent Convalescent plasma therapy coronavirus Coverage COVID-19 COVID-19 convalescent therapy COVID-19 therapy COVID-19 vaccine cytokine diagnosis of COVID-19 disease disease severity Ebola effective H1N1 influenza host response human antibodies IL-17 IL-1β IL-2 IL-6 IL-8 immunological impacted IMPROVE include Infection initial Major management mitigate multiple mutation Neutralizing antibodies novel outbreak pandemic pandemic progresses PCR plasma resulting risk role SARS-CoV-2 SARS-COV-2 infection successive wave survival rate therapy TNFα Treatment Trial unvaccinated population vaccination variant variants of concern viral challenge virulence virulent virus [DOI] 10.3390/life11080734 PMC 바로가기 [Article Type] Review
Which National Factors Are Most Influential in the Spread of COVID-19?Article Published on 2021-07-162022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, 신종인플루엔자, [키워드] age Analysis caused conditions confirmed case country COVID-19 cumulative death death rate Diseases distributions environmental factors example expected extreme Factor global pandemic Growth Curve growth curve models H1N1 influenza Health help investigated Logistic median age MOST National Older outbreak pandemic parameter parameters predicted public health threat resource respiratory virus SARS-CoV-2 selected Spread spread of COVID-19 statistical analysis total population Travel Variation WHO [DOI] 10.3390/ijerph18147592 PMC 바로가기 [Article Type] Article
Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus in the absence of UV-activation in vitro메틸렌 블루는 시험 관내 UV- 활성화의 부재하에 SARS-COV-2 및 H1N1 인플루엔자 바이러스에 대한 강력한 항 바이러스 활성을 갖는다.Article Published on 2021-07-122022-09-01 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] absence Activation addition antiviral activity Antiviral agents approved blood product blood products blue Cell Clinical studies clinical study Concentration Degradation drug effective EMA European Medicines Agency evaluated examined FDA food genomic RNA H1N1 H1N1 influenza immune Immune Serum in vitro infected with SARS-CoV-2 Influenza influenza virus H1N1 malaria mechanism methemoglobinemia Methylene Methylene blue presence or absence safety profile SARS-CoV-2 SARS-CoV-2 infections serum shown Support therapeutic activity therapeutic efficacy Treatment UV light viral infection virucidal virus viruses [DOI] 10.1038/s41598-021-92481-9 PMC 바로가기 [Article Type] Article
Intra-species sialic acid polymorphism in humans: a common niche for influenza and coronavirus pandemics?Review Article Published on 2021-06-142022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, 신종인플루엔자, [키워드] 1918 H1N1 pandemic acute respiratory syndrome Asymptomatic co-evolution confirmed case coronavirus CoV COVID-19 pandemic CoVs death Epidemic Epidemics Evolution Fatality rate General population H1N1 influenza H1N1 pandemic Host impacted infected individual Influenza Influenza and coronavirus Influenza virus mild illness mild symptoms pandemic Pandemics polymorphism receptor recognize severe cases sialic acid sialic acid receptor the United State Variation virus [DOI] 10.1080/22221751.2021.1935329 PMC 바로가기 [Article Type] Review Article