Emergence of circulating influenza A H3N2 viruses with genetic drift in the matrix gene: be alert of false-negative test resultsArticle Published on 2022-10-012023-06-23 Journal: Apmis [Category] 신종인플루엔자, [키워드] assay diagnostic genetic drift H3N2 M gene mutations RT-PCR Sequencing surveillance. [DOI] 10.1111/apm.13262 PMC 바로가기
A Recombinant VSV-Based Bivalent Vaccine Effectively Protects against Both SARS-CoV-2 and Influenza A Virus InfectionArticle Published on 2022-09-282022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 신종인플루엔자, 진단, [키워드] Amino acid animal Bivalent bivalent vaccine C-terminal Cellular immune response conserved contagious COVID-19 Delta delta variant develop domain Ebola ectodomain Efficacy Evidence fused global public health glycoprotein H1N1 H3N2 hamster humoral immunization infections Infectious disease Influenza influenza A virus influenza virus influenza viruses M2 protein mice Neutralizing neutralizing antibody Point mutation PROTECT Protein provide recombinant reduced Respiratory disease respiratory droplet respiratory viral S2 domain SARS-CoV-2 SARS-CoV-2 Delta variant SARS-CoV-2 SP SARS-CoV-2 variant shown significantly Spike protein spike protein. the RBD threat transmitted Vaccine vaccine candidate vaccine platform variant vesicular stomatitis virus VSV VSV vector [DOI] 10.1128/jvi.01337-22 PMC 바로가기
Simultaneous Detection of RIG-1, MDA5, and IFIT-1 Expression Is a Convenient Tool for Evaluation of the Interferon-Mediated ResponseArticle Published on 2022-09-212022-11-15 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] A549 cell acute phase assumed both virus clinical Course cytosolic cytosolic sensors detection disease onset Disease progression donors elevated evaluated expression Genes H3N2 immune response in vitro in vitro transcribed RNAs influenza A influenza A virus inhibit interferon-stimulated gene interferons ISGs MDA5 Mild-to-moderate mRNA expression mRNA level multiple mechanism multiplex not differ observation onset of symptoms pathogenesis of SARS-CoV-2 patients with influenza post infection qPCR qPCR assay qPCR. remained response RNA RNAs SARS-CoV-2 SARS-CoV-2 patient Signaling Simultaneous SOCS-1 the disease transcribed transfected with type I virus White blood cell White blood cells worsening [DOI] 10.3390/v14102090 PMC 바로가기
Developing a Loop-Mediated Isothermal Amplification Assay for the Rapid Detection of Seven Respiratory Viruses including SARS-CoV-2Article Published on 2022-09-052022-11-15 Journal: Medicina [Category] SARS, 신종인플루엔자, 치료기술, 치료제, [키워드] Accuracy acute respiratory syndrome Adenovirus amplification caused coronavirus coronavirus disease COVID-19 cross-reactivity detection develop Developing diagnosis of COVID-19 evaluate facilitate Final H1N1 H3N2 heat-inactivated include Infection Influenza initial symptom isothermal isothermal amplification material median multiplex Nasopharyngeal swab objective overlap pandemic Patient patients PCR performed point-of-care polymerase chain Quantitative quantitative PCR Rapid reagent respiratory respiratory infection respiratory syncytial virus respiratory virus respiratory virus Respiratory virus. respiratory viruses RSV RT-PCR RT-qLAMP RT-qPCR RT-qPCR assay SARS-CoV-2 Sensitivity and specificity Seven specimen strain Symptom target specificity time-consuming Treatment Volume was performed were used [DOI] 10.3390/medicina58091224 PMC 바로가기
The Spanish fluArticle Published on 2022-09-012023-06-23 Journal: La Presse Médicale [Category] 신종인플루엔자, [키워드] Asian flu 1957 Encephalitis lethargica H1N1 H2N2 H3N2 hemagglutinin Hong-Kong flu 1968 Influenzae Myxovirus influenzae neuraminidase pandemic Pandemic H1N1 flu 2009 Spanish flu Von Economo. [DOI] 10.1016/j.lpm.2022.104127 PMC 바로가기
Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmissionArticle Published on 2022-09-012022-11-15 Journal: Biomaterials [Category] COVID19(2023년), SARS, 신종인플루엔자, 치료기술, [키워드] Chewing clinical trial Corona Debulking decrease dose-dependent double-blinded evaluate expressed H1N1 H3N2 HCoV-OC43 IND Infection Influenza investigated linear magnitude N-antigen nasal nasopharyngeal OC43 overlapping Particle phase placebo-controlled plant cells Protein purified reduced reduction Saliva SARS-CoV-2 delta significantly Spike protein strain Transmission transmission of SARS-CoV-2 Viral load virus virus load virus strain [DOI] 10.1016/j.biomaterials.2022.121671 PMC 바로가기
Evidence for deleterious effects of immunological history in SARS-CoV-2SARS-CoV-2에서 면역학적 병력의 유해한 영향에 대한 증거Article Published on 2022-08-242022-09-11 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] Amino acid amino acid change antibodies binding antibody Antigen antigenic association binding binding assay Binding assays blood sample COVID-19 disease COVID-19 disease severity COVID-19 infections cross-reactive cross-reactivity deleterious effect demonstrated epitope H3N2 hallmark hallmarks homologous identify IgG immunological Immunological memory Infection Influenza influenza A influenza A virus influenza infection influenza strain influenza vaccine Injury Patient presence of antibody Protein SARS-CoV-2 SARS-CoV-2 nucleocapsid sequence severe COVID-19 infections underlie upregulation Vaccine widespread [DOI] 10.1371/journal.pone.0272163 PMC 바로가기 [Article Type] Article
M2-Deficient Single-Replication Influenza Vaccine-Induced Immune Responses Associated With Protection Against Human Challenge With Highly Drifted H3N2 Influenza StrainArticle Published on 2022-08-122023-06-14 Journal: The Journal of Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] challenge drift H3N2 Influenza vaccine. [DOI] 10.1093/infdis/jiab374 PMC 바로가기
Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링Article Published on 2022-08-042022-09-11 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제, [키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication [DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article
Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects짧은 이중 가닥, 평활 말단 RNA의 서열 특이적 특징은 RIG-I 및 유형 1 인터페론 의존성 또는 독립적 항바이러스 효과를 갖는다Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] adaptors Adenovirus Anti-viral anti-viral effect Antiviral Antiviral agents Antiviral effect antiviral effects assays Cell cell cycle cell cycle genes cell line cells cellular complementary cytoplasmic DNA DNA virus downregulated dsRNA dsRNAs Effect elicited fibroblast Gene Expression H3N2 human airway IFN IFN-alpha IFN-I IFNAR2 independent independent of indicated Infection Influenza influenza A influenza A virus Influenza virus interferon knock-out library MDA5 mechanism mimicking molecular patterns MYD88 organism Organisms pathogen pathogen-associated molecular patterns Pathogens Randomized receptor required retinoic acid retinoic acid-inducible gene I RIG-I RNA RNA therapy RNA virus RNAs SARS-CoV-2 sequence short double-strand blunt-end RNA. transcriptomics transfection Type ZNFX1 [DOI] 10.3390/v14071407 PMC 바로가기 [Article Type] Article