Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers케냐 유아와 산모의 SARS-CoV-2 감염 전 및 후 풍토성 코로나바이러스에 대한 독특한 항체 반응Article Published on 2022-07-122022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] alphacoronavirus antibody Antibody binding association Betacoronavirus betacoronavirus boosting cause Cohort coronavirus COVID-19 cross-react cross-reactive cross-reactive antibody cross-reactivity Endemic endemic human coronavirus Evidence HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 highly pathogenic IgG IgG antibody titer Infant Infants Kenya lack levels of antibody memory response mother mothers. response risk SARS-CoV-1 SARS-CoV-1 infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection Seroconversion unlikely women [DOI] 10.3390/v14071517 PMC 바로가기 [Article Type] Article
TiO2 Nanostructures That Reduce the Infectivity of Human Respiratory Viruses Including SARS-CoV-2Article Published on 2022-07-112023-07-09 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), [키워드] antibacterial surfaces antiviral surfaces HCoV-NL63 HRV-16 Human coronavirus nanostructured surfaces SARS-CoV-2 Titanium dioxide. [DOI] 10.1021/acsbiomaterials.2c00326 PMC 바로가기
From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease용도 변경에서 재설계까지: SARS-CoV-2 주요 프로테아제의 강력한 억제제에 대한 보세프레비르의 최적화Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 3C-like protease activities activity addition alpha-ketoamides alphacoronavirus approach Betacoronavirus boceprevir complexes Complexes coronavirus COVID-19 coxsackievirus Coxsackievirus B3 crystal structure crystal structures Crystallography enterovirus enterovirus 3C protease exhibited Glutamine HCoV HCoV-NL63 hepatitis C hepatitis C virus inhibitor lactam M pro main protease moderate NL63 optimization potency potent protease Protease inhibitor Proteases replacing repurposing resulting SARS-CoV-2 starting structure-based design Structure-based drug design telaprevir telaprevir. the SARS-CoV-2 treatments for COVID-19 Validity virus X-ray X-ray crystallography [DOI] 10.3390/molecules27134292 PMC 바로가기 [Article Type] Article
Repurposing dyphylline as a pan-coronavirus antiviral therapy범 코로나 바이러스 항 바이러스 요법으로 디필린 용도 변경Article Published on 2022-05-012022-09-11 Journal: Future Medicinal Chemistry [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Alpha Antiviral antiviral agent antiviral therapy bind catalytic dyad Cell culture coronavirus COVID-19 pandemic CoVs Cystine Drug discovery dyphylline FDA-approved drug functional enzyme functional enzymes HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs highly pathogenic histidine Human human coronavirus human coronaviruses human coronaviruses (HCoVs) humans inhibited life cycle Mild MPro NL63 OC43 protease repurposing repurposing. respiratory diseases SARS-CoV-2 severe respiratory disease severe respiratory diseases structures Support targets therapeutically target viral replication Virtual screening virus Virus life cycle viruses xanthine zoonotic [DOI] 10.4155/fmc-2021-0311 PMC 바로가기 [Article Type] Article
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2미세유체 항체 친화성 프로파일링은 SARS-CoV-2에 대한 방어에서 기억 재활성화 및 교차 반응성의 역할을 보여줍니다Article Published on 2022-04-082022-09-12 Journal: ACS Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute SARS-CoV-2 infection ADE adverse effect affinity Against antibody antibody affinity antibody concentration antibody profiling Antibody-dependent enhancement Antigen Concentration convalescent coronavirus Course COVID-19 COVID-19 convalescent patient COVID-19 patient cross-reactive antibodies cross-reactive antibody cross-reactivity Determining detrimental effect effort ELISAs endemic human coronavirus enzyme-linked immunosorbent assay evaluate HCoV-HKU1 HCoV-NL63 humoral immune response Immunity Infection memory memory B-cell memory immunity microfluidics. new SARS-CoV-2 nine parameter Pathogens Profiling Reactivation recent role SARS-CoV-2 SARS-COV-2 infection sequence similarity sera seropositive severity Spike protein the SARS-CoV-2 [DOI] 10.1021/acsinfecdis.1c00486 PMC 바로가기 [Article Type] Article
A Novel Method to Reduce ELISA Serial Dilution Assay Workload Applied to SARS-CoV-2 and Seasonal HCoVsArticle Published on 2022-03-092023-06-14 Journal: Viruses [Category] MERS, SARS, [키워드] Bayesian analysis ELISA endpoint assay HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 hierarchical modelling inflection titer SARS-CoV-2 [DOI] 10.3390/v14030562 PMC 바로가기 [Article Type] Article
Effective presence of antibodies against common human coronaviruses in immunoglobulin medicinal products면역글로불린 의약품에서 일반적인 인간 코로나바이러스에 대한 항체의 효과적인 존재Article Published on 2022-03-012022-09-12 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, [키워드] 229E acute respiratory syndrome administration antibodies antibody cells Concentration conducted contribute Coronavirus-2 cross-reactivity Czech Republic donors ELISA ELISAs enzyme-linked immunosorbent assay explain expressed Germany HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 Human Human coronavirus human coronavirus Immunoglobulin Immunoglobulins. intramuscular intravenous knowledge Neutralization assay NL63 OC43 patients plasma presence of antibody product severity Spain tested the antibody USA [DOI] 10.1016/j.ijid.2021.12.329 PMC 바로가기 [Article Type] Article
Classical and Next-Generation Vaccine Platforms to SARS-CoV-2: Biotechnological Strategies and Genomic VariantsSARS-CoV-2에 대한 고전 및 차세대 백신 플랫폼: 생명공학 전략 및 게놈 변이Review Published on 2022-02-182022-09-10 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] aAPC Ad5-nCoV adaptive Amino acid amino acids animals antibody applied B.1.1.7 B1.351 BBIBP-CorV bind Biotechnology BNT Cell classical clinical trial consequence CoronaVac coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs D614G Deletion demonstrated dendritic cell dendritic cells domain escape Evolution genomic variant genomic variants HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 high affinity HKU1 hosts Human humans inactivated incorporation inhibit INO-4800 JNJ-78436735 lentiviral Lentiviral vector LV-SMENP-DC MERS-CoV molecular mRNA mRNA-1273 mutated nCoV New new SARS-CoV-2 new strain NL63 NVX-CoV2373 vaccine P.1 pathogen Pathogens platform Protein RBD receptor ACE2 Receptor-binding domain recombinant vaccine recombinant vaccines replacement residue responsible RNA vaccines S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants strain Strains Strategy subunits technological platforms tested the S protein Transmissibility trials Vaccine vaccine production Vaccines variant variants variety Viral virus-like particles β-coronavirus β-CoV β-CoVs [DOI] 10.3390/ijerph19042392 PMC 바로가기 [Article Type] Review
Full Genome of batCoV/MinFul/2018/SriLanka, a Novel Alpha-Coronavirus Detected in Miniopterus fuliginosus , Sri LankaArticle Published on 2022-02-072022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] Miniopterus fuliginosus Amino acid bat bat alphacoronavirus bats cave cave-dwelling collected conserved coronavirus CoV full genome Genetic genome sequence HCoV-229E HCoV-NL63 Host humans identity Infection information Mild Miniopterus novel nucleotide one health populations potential transmission Prevalence rectal swab Research resulting risk selected severe respiratory symptoms specificity Sri Lanka strain structural protein sympatric colony Transmission Variation virus β-CoV β-CoVs [DOI] 10.3390/v14020337 PMC 바로가기 [Article Type] Article
Evolution of Viral Pathogens Follows a Linear OrderResearch Article Published on 2022-02-022022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, 신종인플루엔자, [키워드] acute respiratory syndrome addition Amino acid Analysis contribute coronavirus coronavirus coronavirus disease COVID-19 dengue virus determine distribution Evidence Evolution H1N1 H3N2 HCoV-229E HCoV-NL63 HCoV-OC43 Infectious disease influenza A linear linear order MERS MERS-CoV Microbiology Middle East outbreak Outbreaks predict random reveal SARS-CoV SARS-CoV-2 serotype shown subsequent syndrome triggering Vaccine variants of concern viral family viral genome viral mutation viral pathogen virus Zaire Zika [DOI] 10.1128/spectrum.01655-21 PMC 바로가기 [Article Type] Research Article