Very early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial고위험 비-ST 상승 심근경색증에서 초기 침습성 혈관조영술과 표준 치료 비교: 전향적 다기관 무작위 대조 RAPID N-STEMI 시험을 위한 연구 프로토콜Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] 임상, [키워드] all-cause mortality Analysis approved bleeding Cambridge Clinical outcome clinical outcomes completion Coronary coronary angiography Coronary heart disease coronary intervention COVID-19 pandemic defined determine East East of England England enrolled enrolment Ethics ethics committee event event rates expected heart disease heart failure Hospital admission Hypothesis IMPROVE include Infarct invasive Ischaemic heart disease major bleeding mechanistic data multicentre Myocardial Myocardial infarction Neutral Open-label participant Patient patients Percutaneous coronary intervention Pragmatic Primary outcome proportion randomised randomised controlled recommendation registration number registry Research Ethics retrospective secondary outcome Sponsor Standard of care stroke Study protocol submitted Trial trials within 6 months [DOI] 10.1136/bmjopen-2021-055878 PMC 바로가기 [Article Type] Article
Possibility as role of ginseng and ginsenosides on inhibiting the heart disease of COVID-19: A systematic reviewReview article Published on 2022-05-012022-10-05 Journal: Journal of Ginseng Research [Category] 바이오마커, [키워드] ACE2 receptor antioxidant Asymptomatic blood flow blood pressure cardiovascular complication cardiovascular complications caused China Coronavirus infection COVID-19 death disease Efficacy Evidence ginseng heart disease heart failure inhibiting mechanism Myocardial infarction Prevent Previous studies protection reduce reduce mortality Research respiratory risk SARS-CoV-2 severe pneumonia subclinical infection suppress systematic review Treatment Vascular [DOI] 10.1016/j.jgr.2022.01.003 [Article Type] Review article
Associations Between Recently Diagnosed Conditions and Hospitalization due to COVID-19 in Patients Aged 50 Years and Older-A SHARE-Based Analysis50세 이상 환자의 최근 진단된 상태와 COVID-19로 인한 입원 간의 연관성-A SHARE 기반 분석Article Published on 2022-04-012022-09-11 Journal: The Journals of Gerontology Series A: Biological S [Category] COVID19(2023년), SARS, 치료기술, [키워드] adjusted odds ratio Ageing AOR association average Cancer carried chronic condition chronic conditions condition conditions coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hospitalization diabetes diagnosed disease Diseases Europe European country evaluate heart disease Hospitalization Hospitalized hypertension individual large sample Lung disease Multimorbidity multivariable logistic regression Older older population outcome participant Research retirement retrieved SARS-CoV-2 significantly higher significantly more survey were assessed Year [DOI] 10.1093/gerona/glab199 PMC 바로가기 [Article Type] Article
Overview of clinical outcome and therapeutic effectiveness of Favipiravir in patients with COVID-19 admitted to intensive care unit, Riyadh, Saudi Arabia사우디아라비아 리야드의 중환자실에 입원한 COVID-19 환자에 대한 Favipiravir의 임상 결과 및 치료 효과 개요Article Published on 2022-04-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 임상, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome age analyzed antivirals approved ARDS BMI body mass body mass index Chloroquine Clinical outcome collected Comorbidities Comorbidity complications conducted control group Corticosteroid cough COVID-19 COVID-19 patient COVID-19 vaccine Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine Cytokine storm diabetes Diabetes Mellitus effective Effectiveness Efficacy Efficacy and safety enrolled enzyme Favipiravir Fever FIVE FVP group had no heart disease hospital hypertension ICU ICUs IMPROVE inhibit intensive care intensive care unit intensive care units ischemic heart disease Kingdom majority male management medications not effective other treatment other treatments overall mortality P-value pandemic Patient patients with COVID-19 Potential treatment Randomized Research respiratory distress Respiratory distress syndrome retrospective cohort study RNA RNA polymerase Saudi Arabia severe acute respiratory distress syndrome severe symptoms Shortness of breath statistically significant Symptom syndrome the cytokine storm the disease the mean therapeutic therapeutic efficacy therapy Tocilizumab two groups Viral viral infection viral infections viral replication with COVID-19 [DOI] 10.1016/j.jiph.2022.01.013 PMC 바로가기 [Article Type] Article
Cytokine cascade in Kawasaki disease versus Kawasaki-like syndrome가와사키병 대 가와사키 유사 증후군의 사이토카인 캐스케이드Review Published on 2022-03-252022-09-11 Journal: Physiological research [Category] SARS, 유전자 메커니즘, [키워드] acquired heart disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Aneurysm autoantibody Autoimmunity cardiovascular complications cascade caspase caspase 3 cause caused Cell Characteristics characterized children Coronary artery coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine level Cytokine release syndrome Cytokine storm Cytokines defined Diagnosis Factor febrile FIVE Genetic heart disease hypercytokinemia Hyperinflammatory Hypothesis IFN-gamma IL-10 IL-2 IL-4 IL-6 immunothrombosis induce Infection Inflammatory Kawasaki disease Kawasaki-like syndrome medium MIS-C myocarditis occur Pathogenesis pathogenic mechanism pathophysiology pediatric PIMS protocol respiratory virus respiratory viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus Shock susceptibility syndrome systemic inflammatory response systemic vasculitis the disease TNF-alpha Treatment triggered Vasculitis vessel [DOI] 10.33549/physiolres.934672 PMC 바로가기 [Article Type] Review
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes게놈 전반에 걸친 분석을 통해 SARS-CoV-2 바이러스 유전자 Orf9c가 인간 다능성 줄기 세포 유래 심근세포에 미치는 해로운 영향을 보여줍니다Article Published on 2022-03-082022-09-11 Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated analyses Analysis Apoptosis apoptotic approved ATP ATP synthesis cardiac dysfunction cardiac injury cardiomyocyte caused Cell cellular characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death defined detrimental detrimental effect detrimental effects disease down-regulated drug Drug administration dysfunction electrical ENCODE expression Factor Factors food functional Genes Genome heart disease heart muscle human pluripotent stem cell Impact Inflammation Injury Ivermectin manifestation Manifestations meclizine meclizine. molecular mechanism molecular mechanisms Orf9c overexpression Pathways Protein Proteins Proteomic analysis reduced respiratory restored SARS-CoV-2 SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly stem cell Therapeutic approach Transcriptomic analyses transcriptomic analysis U.S. Food and Drug Administration up-regulated [DOI] 10.1016/j.stemcr.2022.01.014 PMC 바로가기 [Article Type] Article
Imaging Findings of COVID-19-Related Cardiovascular ComplicationsCOVID-19 관련 심혈관 합병증의 영상 소견Review Published on 2022-03-012022-09-11 Journal: Cardiac electrophysiology clinics [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome Asymptomatic BNP cardiac death Cardiogenic shock cardiovascular Cardiovascular magnetic resonance (CMR) Clinical course clinical presentation Clinical presentations Complication coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients death Diagnosis disease finding heart disease imaging increased mortality Manifestations myocardial injury myocarditis Other Patient Pulmonary embolism Respiratory disease risk factor risk stratification Severe acute respiratory syndrome Shock Side effect sudden cardiac death Treatment troponin Vaccine [DOI] 10.1016/j.ccep.2021.10.008 PMC 바로가기 [Article Type] Review
QTc interval prolongation in patients infected with SARS-CoV-2 and treated with antiviral drugsSARS-CoV-2에 감염되어 항바이러스제 치료를 받은 환자의 QTc 간격 연장Article Published on 2022-03-012022-09-11 Journal: Anales de pediatria [Category] COVID19(2023년), SARS, 치료제, [키워드] adverse effect affected analyzed Antiviral Antiviral agents antiviral drug antiviral therapy arrhythmia Azithromycin Azitromicin Azitromicina basal baseline caused Child congenital heart disease Control COVID-19 disease electrocardiogram Electrocardiograma Electrocardiograms Electrocardiography English event heart disease Hidroxicloroquina hubo Hydroxychloroquine Immunosuppression increase in infected with SARS-CoV-2 Long Long QT syndrome Lopinavir Lopinavir/ritonavir median no difference no differences paediatric patients Patient patients Pediatría pediatrics QT largo QTc QTc interval QTC prolongation Remdesivir resulting Ritonavir SARS-CoV-2 Spanish treat treated Treatment underlying diseases use of hydroxychloroquine ventricular [DOI] 10.1016/j.anpede.2021.04.006 PMC 바로가기 [Article Type] Article
A global picture: therapeutic perspectives for COVID-19글로벌 그림: COVID-19에 대한 치료적 관점Review Published on 2022-02-212022-09-10 Journal: Immunotherapy [Category] COVID19(2023년), MERS, SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affected age cause Complication Consequences Coronary heart disease coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic determine disorder drug drug discovery process drug dose Drug repurposing drug target event fatty Fatty liver heart disease illness include information life cycle management Metabolic disorders Numerous outbreak overweight pandemic patients Perspective pulmonary disease recovered patients renal renal failure Repurposed drug Repurposed drugs Research research and development respiratory SARS-CoV-2 serious COVID-19 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 subsequent the disease therapeutic therapeutic agent therapeutic agents treat Vaccine Vaccine development Vaccines Viral Viral transmission virus [DOI] 10.2217/imt-2021-0168 PMC 바로가기 [Article Type] Review
Risk Factors for Severe COVID-19 in Children: A Systematic Review and Meta-Analysis소아에서 심각한 COVID-19의 위험 요소: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-02-072022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval achievement acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Adults age article Asthma children children with COVID-19 chronic lung disease chronic lung diseases Clinical course Comorbidities Comorbidity contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Critical illness database death Decision making diabete diabetes disease disorder disorders Enrollment Factor heart disease help high risk Hospital admission Hospitalization hospitalizations Immunocompromised immunocompromised status Infant infected with SARS-CoV-2 intensive care intensive care unit admission Invasive mechanical ventilation Lung disease Meta-analysis Neonate neurologic obesity outcome Premature Prematurity Prevalence priority review risk risk factor Risk factors risk ratio risk stratification SARS-CoV-2 SARS-COV-2 infection screened Seizure severe COVID-19 subgroup analysis systematic review vaccination vaccination rate variant variants was performed [DOI] 10.3346/jkms.2022.37.e35 PMC 바로가기 [Article Type] Meta-Analysis