Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trialCOVID-19 입원 환자의 바이러스 역학에 대한 렘데시비르의 효과: 무작위, 통제, 공개 라벨 DisCoVeRy 시험의 모델링 분석Randomized Controlled Trial Published on 2022-04-272022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 95% CI analysed Analysis antiviral efficacy average cells conducted COVID-19 Effect Efficacy EudraCT high viral load Hospitalized hospitalized patient hospitalized patients infected cell infected cells inter-individual kinetic mathematical mathematical model median median time nasopharyngeal normalized Open-label Patient predict profile randomization Randomized reduced reducing reduction Remdesivir SOC Standard of care stratified symptom onset the median treatment initiation Trial Variability viral clearance viral dynamics Viral load viral loads viral replication [DOI] 10.1093/jac/dkac048 PMC 바로가기 [Article Type] Randomized Controlled Trial
Field Evaluation of the New Rapid NG-Test ® SARS-CoV-2 Ag for Diagnosis of COVID-19 in the Emergency Department of an Academic Referral Hospital학술 추천 병원 응급실에서 COVID-19 진단을 위한 새로운 Rapid NG-Test ® SARS-CoV-2 Ag의 현장 평가Article Published on 2022-04-252022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI acute infection affecting ambulatory patient analyzed Antigen antigen test COVID-19 COVID-19 pandemic Department determine Diagnosis diagnostic diagnostics Emergency emergency department evaluate field Greece high viral load hospital immunoassay lateral flow lateral flow immunoassay nasopharyngeal New NG-Test® SARS-CoV-2 Ag NP swab NP swabs NPV numbers of patients Oropharyngeal Patient PCR testing per day point-of-care point-of-care test point-of-care tests positive PPV Predictive presenting qualitative detection Rapid rapid diagnostics Referral RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 PCR testing sensitivity specificity swabs tested university Viral load viral loads [DOI] 10.3389/fpubh.2022.840984 PMC 바로가기 [Article Type] Article
Emulation of a Target Trial From Observational Data to Compare Effectiveness of Casirivimab/Imdevimab and Bamlanivimab/Etesevimab for Early Treatment of Non-Hospitalized Patients With COVID-19COVID-19로 입원하지 않은 환자의 조기 치료를 위한 Casirivimab/Imdevimab 및 Bamlanivimab/Etesevimab의 효과를 비교하기 위한 관찰 데이터의 표적 시험 에뮬레이션Clinical Trial Published on 2022-04-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] adjusted allocation Alpha Analysis ANCOVA bamlanivimab bamlanivimab/etesevimab baseline carried Casirivimab casirivimab/imdevimab Combination Comparative analysis COVID-19 Cox model Ct value cycle threshold death Delta determine early treatment early treatment for COVID-19 Effectiveness enrolment etesevimab evaluated Evidence Factor Factors high viral load Hospitalization Imdevimab in viral Intervention Logistic regression mAb mAbs Mild-to-moderate Model Modification monoclonal antibodies monoclonal antibody Nasopharyngeal swab negative RT-PCR not used Observational data occurred outcome Outpatient outpatients Patient PCR test Primary outcome Probability progression reduced risk reduction Relative risk risk reduction RT-PCR test SARS-CoV-2 Stratification subject target Treatment Trial two group two groups vaccination variants variants of concern Viral Viral load viral load reduction virological response VOCs was measured was used were used [DOI] 10.3389/fimmu.2022.868020 PMC 바로가기 [Article Type] Clinical Trial
Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired TranscriptionCOVID-19 폐 부검 표본의 다중 디자인 차등 발현 프로파일링은 상당히 규제 완화된 염증 경로 및 SFTPC 손상된 전사를 나타냅니다Article Published on 2022-03-162022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] Activation Autopsy carried cathepsin Cathepsin C CD163 CFB Clinical diagnosis complement Complement activation controls COVID-19 COVID-19 patient COVID-19-related death CTSC deaths deregulation develop differential expression effective effective therapy FFPE formalin formalin-fixed paraffin-embedded Gene expression profiling had no high viral load IFIT1 immune signature immunohistochemistry Impaired Inflammation ISG15 lung lung damage Macrophage macrophage polarization mechanism MS4A4A Nasopharyngeal swab OAS1 overexpression paraffin pathway pharmacological strategies PKM positive potential therapeutic targets Prevent probe Profiling Protein protein C pulmonary viral quantified required Respiratory disease RNA RNA-Seq RSAD2 SARS-CoV-2 SARS-COV-2 infection selected Seven SFTPC Siglec-1 SIGLEC1 signaling pathway specimen tissue sample tissue samples transcriptomic Transcriptomic profiling type I interferon Viral load were used [DOI] 10.3390/cells11061011 PMC 바로가기 [Article Type] Article
Protective Immunity of the Primary SARS-CoV-2 Infection Reduces Disease Severity Post Re-Infection with Delta Variants in Syrian Hamsters1차 SARS-CoV-2 감염의 보호 면역은 시리아 햄스터의 델타 변종으로 재감염 후 질병 심각도를 감소시킵니다Article Published on 2022-03-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acute respiratory syndrome AY.1 B.1 caused Characteristics characterized coronavirus disease Coronavirus disease 2019 Delta Delta AY.1 delta variant disease disease severity dominant dose Evidence evidence of groups hamster hamsters high viral load Immunity Infection initial interstitial pneumonia K417N K417N mutation lineages Lung disease Mild Mild disease neutralization Neutralizing neutralizing antibody pathogenicity produced re-infected Re-infection Re-infections reduce reduced reduction in Reinfection remained respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 lineage Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 sterilizing immunity Syrian hamsters the disease upper upper respiratory tract variant variants Viral load viral RNA load virus [DOI] 10.3390/v14030596 PMC 바로가기 [Article Type] Article
A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concernBrevibacillus의 열안정성 Cas12b는 우려되는 SARS-CoV-2 변이체의 원팟 식별을 활용합니다.Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] SARS, 변종, 치료기술, [키워드] Accuracy activity Alicyclobacillus Alpha amplification applied B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Breast Breast cancer Cas12b center clinical samples college Complete Control COVID-19 CRISPR Ct value current Delta detection system diagnostics differential scanning fluorimetry disease control dissemination Dual-detection Engineering facilitate foundation fraction Gamma guide RNA high viral load house implementation isothermal amplification lack landscape Loop-mediated isothermal amplification Medicine Negative predictive value NIAID offer office omicron One-pot detection overcome P.1 Palindromic Pathogens platform point-of-care positive Predictive value President prevention primer Protein purified qPCR reaction reagent Real-time monitoring reverse transcription robust RT-LAMP S gene SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 variant Science sensitivity Sequencing SPADE specificity technology the SARS-CoV-2 Thermophillic university variants variants of concern veterinary medicine vice Vice President Viral load VoC VOCs were expressed [DOI] 10.1016/j.ebiom.2022.103926 PMC 바로가기 [Article Type] Article
SARS-CoV-2 rapid antigen test in comparison to RT-PCR targeting different genes: A real-life evaluation among unselected patients in a regional hospital of ItalySARS-CoV-2 신속항원 검사와 다른 유전자 표적 RT-PCR 비교: 이탈리아 지역 병원에서 선별되지 않은 환자를 대상으로 한 실생활 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigen detection Calabria caution Chain Reaction coronavirus Cycling diagnostic Discordance gene target high viral load hospital identify indicated Infection IRCCS Italy molecular test Negative predictive value PanBio Panbio™ COVID-19 Patient polymerase chain reaction positive Positive predictive value Positive test positive test result Predictive value presenting Prevalence processed RAD reverse transcriptase RT-PCR SARS-CoV-2 Sensitivity and specificity severe acute respiratory syndrome Coronavirus shown significantly lower stratified subject Support Swab swabs test result tested threshold Viral load Volume [DOI] 10.1002/jmv.27378 PMC 바로가기 [Article Type] Article
Acute SARS-CoV-2 alpha variant infection leading to placental insufficiency and fetal distress태반 기능 부전 및 태아 고통을 유발하는 급성 SARS-CoV-2 알파 변이체 감염Case Reports Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age Alpha Alpha variant B.1.1.7 B.1.1.7 lineage Brain Care Cesarean section coronavirus demonstrated distress fetal fetal distress fetal movement FIBRIN gestational age high viral load hospital induce Infection intensive care Ischemic necrosis Maternal Health Medical care Necrosis Neonatal neonatal intensive care unit Neonate Obstetric obstetric infection obstetrics oligohydramnios pathological Pathological examination pathology Placenta placental placental insufficiency placental tissue placentitis positive Pregnancy reduced reduced fetal movement SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 infected patients seeking severe acute respiratory syndrome Coronavirus subsequent tested the SARS-CoV-2 umbilical umbilical artery variant Viral load VOC 202012/01 was performed [DOI] 10.1002/jmv.27379 PMC 바로가기 [Article Type] Case Reports
Isolation and Genomic Characterization of SARS-CoV-2 Omicron Variant Obtained from Human Clinical Specimens인간 임상 표본에서 얻은 SARS-CoV-2 오미크론 변이체의 분리 및 게놈 특성화Article Published on 2022-02-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] absence Analysis approach B.1.1.529 Cell Cell culture cell suspension changes in characterization clinical collected Contact COVID-19 cases Cytopathic effect demonstrated E gene failure followed by furin furin cleavage site Genome genome analysis hamster hamsters high viral load Host Human in vitro in vivo India infected cell infected cells initial inoculated International Isolation lung Mumbai Mutation nasal nasal turbinate Next-generation sequencing nucleotide omicron Omicron variant passage passages pathogenicity positive Replication SARS-CoV-2 sequence sequenced specimen specimens spike gene subsequent Syrian hamster tyrosine variant Vero CCL-81 Vero CCL-81 cell Vero CCL-81 cells Viral load virus virus isolate virus isolation [DOI] 10.3390/v14030461 PMC 바로가기 [Article Type] Article
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations노화된 전혈 전사체는 SARS-CoV-2 관련 혈관 및 면역 변화에 대한 후보 유전자를 나타냅니다Article Published on 2022-02-012022-09-11 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adhesion affected age aging alteration anti-apoptotic BAG3 Blood Blood clots blood component blood components candidate candidate gene cascade cathepsin Cathepsins CCL4L2 CD14 CD4 CD8 Cell changes in clinical manifestation coronavirus COVID-19 CTSE CTSW database DEGs differentially expressed gene Differentially expressed genes DUSP4 expressed expression expression levels expression profile FASL FASLG female genders gene expression profile high viral load highest HLA-DRA Hyperinflammatory identify IFN IFN signaling immune immune response increase increase in increased expression individual Inflammation interact Interaction interferon investigated involved LAG3 Monocytes naïve T cells natural killer cell Natural killer cells Older older patient older patients overexpress overexpression PDCD1 Peripheral blood Platelet prediction Protein reveal RGS2 risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients sequencing data severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling Single-cell RNA-sequencing T cell T cell exhaustion T cells T lymphocytes target targets therapeutic TIGIT TOX Transcriptome translated type I interferon Vascular VCAM1 Viral load Viral protein Viral proteins Whole blood whole blood transcriptome [DOI] 10.1007/s00109-021-02161-4 PMC 바로가기 [Article Type] Article