In silico prediction of structure and function for a large family of transmembrane proteins that includes human Tmem41b인간 Tmem41b를 포함하는 막횡단 단백질의 대규모 패밀리에 대한 구조 및 기능의 실리코 예측Research Article Published on 2021-03-252022-09-11 Journal: F1000Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] ab initio modelling Analysis autophagy bioinformatics Bioinformatics analysis contact predictions DedA domain early stage early stages embryonic embryonic development evolutionary covariance family feature Features highlight homologue homologues Host include information involved less Local mechanism Pfam domain predicted Protein Data Bank recent rotational symmetry SARS-CoV-2 sequence Sequence analysis shown structural biology tandem repeat Tmem41b transmembrane protein Transport Viral VTT domain [DOI] 10.12688/f1000research.27676.2 PMC 바로가기 [Article Type] Research Article
Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19미립자 물질 및 특발성 폐 섬유증에 의한 ACE2 및 TMPRSS2의 상향 조절: 심각한 COVID-19의 잠재적 역할Research Published on 2021-03-112022-09-10 Journal: Particle and Fibre Toxicology [Category] SARS, 유전자 메커니즘, 진단, [키워드] ACE2 Air pollution alveolar cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal model animal models Bleomycin blocked caused Cell co-expressed COVID-19 COVID-19 disease COVID-19 disease severity CXCR1 Deletion Deterioration entry of SARS-CoV-2 enzyme expressing expression expression level fibroblast fibroblasts fibrosis homologue Idiopathic pulmonary fibrosis IL-8 inhibitor involved IPF lung lung alveolar lung tissue lung tissues mechanism molecular murine Particulate matter pathway patients poor prognosis prevented Protein pulmonary fibrosis receptor Reparixin Result risk SARS-COV-2 infection Serine severe COVID-19 severity specific protein suggested supplementary material These data tissue TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Treatment upregulated upregulating were also expressed [DOI] 10.1186/s12989-021-00404-3 PMC 바로가기 [Article Type] Research
Computational screening for potential drug candidates against the SARS-CoV-2 main proteaseResearch Article Published on 2020-12-212022-10-31 Journal: F1000Research [Category] COVID-19, SARS, [키워드] 6LU7 Compound conserved coronavirus disease Coronaviruses COVID-19 dataset develop docking drug drug candidate drug target Effect effective exhibited homologue Hydroxychloroquine in vitro in vivo inhibitors Interaction kDa Ligand ligands M pro natural compounds pandemic pathogenicity performed pharmacophore positive positive-sense protease Remdesivir SARS-CoV-2 SARS-CoV-2 protease screened selected single-stranded RNA virus Structure tested the Coronaviridae the SARS-CoV-2 viral replication Virtual screening virus [DOI] 10.12688/f1000research.23829.2 PMC 바로가기 [Article Type] Research Article
A pocket guide on how to structure SARS-CoV-2 drugs and therapiesSARS-CoV-2 약물 및 치료법을 구성하는 방법에 대한 포켓 가이드Review Published on 2020-12-182022-09-11 Journal: Biochemical Society Transactions [Category] SARS, 신약개발, 치료제, [키워드] clinical trial clinical trials Community COVID-19 COVID19 defined disease Drug discovery FIVE homologue identify Informing Intervention MERS MERS-CoV Replication Research resolved SARS-CoV SARS-CoV-2 SARS-CoV-2 drug SARS-CoV-2 proteins SARS-CoV-2 virus Stage structural biology Structure the SARS-CoV-2 virus Therapeutics therapy Treatment vaccination Viral viral replication virus [DOI] 10.1042/BST20200396 PMC 바로가기 [Article Type] Review
ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoVStructural Biology Published on 2020-11-042022-10-31 Journal: Clinical Science (London, England : 1979) [Category] COVID-19, SARS, [키워드] ACE ACE inhibitor ACE2 acute respiratory syndrome Alzheimer’s dementia Analysis angiotensin converting enzyme angiotensin converting enzyme 2 blood pressure body fluid cardiovascular disease cleave coronavirus COVID-19 Cryo-electron microscopy disease fibrosis function functional highlight homologue Immunity Infectious disease insecticides Interaction involved Like Lineage mechanism mechanisms metalloproteases methodology obesity organism pandemic physiological provide RAAS receptor Regulation responsible SARS-CoV SARS-CoV-2 substrate therapy tissues Treatment turn understanding X-ray crystallography [DOI] 10.1042/CS20200899 PMC 바로가기 [Article Type] Structural Biology
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamideCell Death & Injury Published on 2020-10-302022-10-28 Journal: Bioscience Reports [Category] COVID-19, MERS, SARS, [키워드] activated Activation ADP-ribose Aryl hydrocarbon receptor ATP biochemical Cancer caused cell death chronic obstructive clinical care component COPD Coronaviruses COVID-19 Critical cytokine determine drugs effective Efficacy ENhance enzyme event expression Gene Expression glucocorticoid Glucocorticoids HIV infection homologue Immunity Immunotherapy Indoleamine 2,3-dioxygenase induce information inhibit inhibitor intensive care Kynurenine pathway lung Lung injury NADP nicotinamide nuclear overexpressed PARP pathophysiology Patient patient mortality Poly (ADP-ribose) polymerase polymerase potent Prevent proinflammatory Proinflammatory cytokine pulmonary disease regulate Regulation respiratory syncytial virus RSV sequence silent sirtuin therapeutic use therapy Trial [DOI] 10.1042/BSR20202856 PMC 바로가기 [Article Type] Cell Death & Injury
Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2Article Published on 2020-10-062022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activity bats bind complex Consequences COVID-19 crystal function global pandemic homologue inhibitor non-structural protein non-structural proteins NSP nsp10 replication–transcription complex respiratory RNA capping machinery RNA genome SARS CoV-2 SARS-CoV-2 sequence similarity Sequencing similarity spread to stimulate Structure Viral RNA virus replication [DOI] 10.3390/ijms21197375 PMC 바로가기 [Article Type] Article
In-silico design of a potential inhibitor of SARS-CoV-2 S proteinSARS-CoV-2 S 단백질의 잠재적 억제제의 in-silico 설계Research Article Published on 2020-10-012022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] ACE2 ACE2 binding site angiotensin angiotensin-converting enzyme 2 approach attachment bind binding binding affinity caused Coronavirus infection Docking studies docking study domain glycoprotein homologue human cell inhibitor International molecular pandemic peptide peptides protease Protein public health emergency RBD receptor Receptor binding domain Registered S protein SARS-CoV-2 S protein SARS-CoV-2 virus therapy Treatment Viral viral infection [DOI] 10.1371/journal.pone.0240004 PMC 바로가기 [Article Type] Research Article
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexesResearch Papers Published on 2020-09-012022-10-29 Journal: IUCrJ [Category] COVID-19, [키워드] ADP-ribose ADP-ribose phosphatase domain ADP-ribosylation adRP antiviral therapeutics apo form appear build complexes conformational change conserved coronavirus COVID-19 crystal structure domain ENCODE enzyme FIVE High-resolution homologue Host immune response hydrolysis interfere Ligand Mac1 macrodomain MES molecular target nonstructural protein Nsp3 phosphatase Protein Research respiratory RNA SARS-CoV-2 shown undergo viruses [DOI] 10.1107/S2052252520009653 PMC 바로가기 [Article Type] Research Papers
Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein PrimingArticle Published on 2020-05-222022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] Anthrax toxin bacterial toxin cleavage site cleavage sites comparison Confusion coronavirus Coronaviruses COVID19 Critical cross determine develop effective effort furin Genome highly pathogenic homologue host serine protease human host in vivo inhibitor involved less MERS-CoV Mutation Pandemics pathogenic strain pathogenicity Potential priming processed processing Protease inhibitor Proteases protecting antigen recent Receptor binding domain S-protein S2′ cleavage SARS-CoV2 sequence serine protease serine protease inhibitor spike spike glycoprotein targeting TMPRSS2 Toxicity Viral protein virulence virus [DOI] 10.3390/molecules25102424 PMC 바로가기 [Article Type] Article