Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patientsArticle Published on 2022-10-012022-11-15 Journal: Infection [Category] COVID19(2023년), SARS, 치료제, [키워드] Admission Analysis antivirals clinical manifestation collected COVID-19 COVID19 Ct value cycle threshold Day Days of symptoms demographic duration of symptom Efficacy evaluate Factor Factors highest Hospital admission hospitalized COVID-19 patient hospitalized patient identify Impact Inclusion laboratory parameter Mortality mortality rate Multivariate analysis Nasopharyngeal swab Patient performed positive predictor reverse transcription rRT-PCR SARS-CoV-2 viral load study population symptoms onset three group Viral load was performed [DOI] 10.1007/s15010-022-01833-8 PMC 바로가기
Cystatin C is associated with adverse COVID-19 outcomes in diverse populationsResearch article Published on 2022-10-012022-10-05 Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, 임상, [키워드] 95% CI African analyzed association Cohort cohort of patient courses COVID-19 Critical cystatin C demonstrated European Factor functional Hospitalized hospitalized COVID-19 patient Host host response human metabolism ICU admission independent Logistic regression Mortality outcome Patient patients with COVID-19 performed plasma Population populations Predictive prognostic proteomics Stratification UKB Virology with COVID-19 [DOI] 10.1016/j.isci.2022.105040 [Article Type] Research article
IL-6 drives T cell death to participate in lymphopenia in COVID-19Research article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] activated T cells affecting analyzed caused CD4+ T cell change Course COVID-19 COVID-19 cytokine storm COVID-19 patients Critical death disease Disease progression early stage Hospitalization hospitalized COVID-19 patient ICU care IFN-γ IL-1β IL-6 Immune status induce infected patients Infection laboratory result lymphopenia maintain observation Patient patients patients with COVID-19 plasma concentration predict pyroptosis Randomly reduction reduction in Result SARS-CoV-2 selected severity supported T cell T cell lymphopenia T lymphocyte T-cell the disease TNF-α [DOI] 10.1016/j.intimp.2022.109132 [Article Type] Research article
Black Fungus and beyond: COVID-19 associated infectionsReview article Published on 2022-10-012022-10-05 Journal: Clinical imaging [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, [키워드] Bacterial black changes in clinical manifestation Clinical outcome Co-infection Complication consolidation COVID-19 COVID-19 infection COVID-19 patient deviation differential diagnosis expected fungal fungus hospitalized COVID-19 patient Infection infections Inflammatory opportunistic infection outcome Patient patient population physician radiologic reported Superimposed infection thrombotic while worsening [DOI] 10.1016/j.clinimag.2022.07.005 [Article Type] Review article
COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patientsShort communication Published on 2022-10-012022-10-30 Journal: Contemporary Clinical Trials Communications [Category] COVID-19, 임상, 치료법, [키워드] AE/SAE Analysis Angiotensin converting enzyme inhibitor (ACEi) Angiotensin II receptor Blocker (ARB) Arm baseline controls COVID-19 COVID-19 patients double-blinded Efficacy and safety Enrollment Final hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine IMPROVE Lopinavir-ritonavir losartan Mortality MOST objective outcome pandemic parameter Patient Placebo placebo-controlled platform primary endpoint Randomized randomized clinical trial Randomized clinical trial (RCT) RCT Result SARS-CoV-2 score slow standard care the mean Treatment [DOI] 10.1016/j.conctc.2022.100968 [Article Type] Short communication
Mortality Risk Among Patients Hospitalized Primarily for COVID-19 During the Omicron and Delta Variant Pandemic Periods – United States, April 2020-June 2022Article Published on 2022-09-162022-11-16 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, [키워드] adjusted age calculated cause CDC Clinical characteristics COVID-19 COVID-19 hospitalization database deaths Delta early treatment Ethnic groups females Health authority hospital hospitalized COVID-19 patient hospitalized patients In-hospital death in-hospital mortality increase indicated lower mortality male medical condition Medical conditions Mortality mortality risk nonpharmaceutical intervention occurred omicron pandemic Patient patients hospitalized Period proportion public health Racial reported risk United States variant variant of SARS-CoV-2 virus [DOI] 10.15585/mmwr.mm7137a4 PMC 바로가기
Longitudinal profiles of plasma gelsolin, cytokines and antibody expression predict COVID-19 severity and hospitalization outcomesArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] actin-binding protein Analysis anti-Spike IgG antibody blood sample Clinical management clinical parameter collected Combination Control correlated COVID-19 COVID-19 disease COVID-19 hospitalization COVID-19 negative COVID-19 patient COVID-19 severity CRP CRP-C-reactive protein cytokine death develop disease disease pathogenesis expression ferritin Gelsolin greater health system healthy individuals Hospitalization hospitalized COVID-19 patient IgG IL-6 IMPROVE innate immune Intervention involved IP-10 Laboratory longitudinal M-CSF marker outcome outcomes plasma platform predict profile prognostic Prognostic marker reduced Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SEM significantly utility viral infections while [DOI] 10.3389/fimmu.2022.1011084 PMC 바로가기
Early reduction of estimated Glomerular Filtration Rate (eGFR) predicts poor outcome in acutely ill hospitalized COVID-19 patients firstly admitted to medical regular wards (eGFR-COV19 study)Research article Published on 2022-09-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Acute kidney injury Admission age Analysis analyzed ARDS association AUC Autopsy baseline value calculated Chronic kidney disease correlated COVID-19 creatinine diagnosed died discharge division Efficacy GFR glomerular filtration rate hospital Hospital admission hospital discharge hospitalized COVID-19 patient hospitalized patient ICU identify IL-6 IMV In-hospital death in-hospital mortality Infection intensive care internal Invasive mechanical ventilation KDIGO AKI kidney Kidney injury mechanical ventilation Medicine NIV non-invasive ventilation outcome Patient patients patients’ medical record predict Predictive Primary outcome Prognosis Rate reduction renal dysfunction renal function representing Result SARS-CoV-2 score Secondary outcomes Serum level significantly significantly lower statistical analysis symptomatic Symptoms tissue were assessed with COVID-19 [DOI] 10.1016/j.biopha.2022.113454 [Article Type] Research article
Charlson comorbidity index, neutrophil-to-lymphocyte ratio and undertreatment with renin-angiotensin-aldosterone system inhibitors predict in-hospital mortality of hospitalized COVID-19 patients during the omicron dominant periodArticle Published on 2022-08-252022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 95%CI absence analyzed Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers ARBs blocker Care CCI Charlson comobidity index clinician Comorbidity Coronavirus disease 2019 COVID-19 COVID-19 patient cut-off value died discharged dominant echocardiographic Endpoint greater help high-risk patient Hospital admission Hospitalization Hospitalized hospitalized COVID-19 patient hospitalized patient in-hospital mortality Infection inhibitor Laboratory laboratory-confirmed males Mortality mortality risk Neutrophil-to-lymphocyte ratio NLR Older omicron Patient physical predict predicted predictor Prevalence prognostic indicator Radiographic receptor reduce risk stratification significantly the primary endpoint therapy [DOI] 10.3389/fimmu.2022.958418 PMC 바로가기
Immunologic phenotype of patients with long-COVID syndrome of 1-year durationArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] 95% confidence interval Adjusted analysis adjusted hazard ratio analyzed antibody Antibody Response antibody response, antinuclear antibodies (ANA) Autoimmunity Biomarker blood sample C-reactive protein cellular Cellular immune response cellular immune responses chronic inflammation COVID-19 COVID-19 symptom D-dimer detectable discharged Follow-up Frequency groups hospital hospitalized COVID-19 patient humoral humoral immune response ICU admission immune immune response Immunologic include Inflammation information Level Long COVID long-COVID mitigate myalgia neutralizing antibody no difference not different One year pathophysiology Patient phenotype positive Post-COVID-19 syndrome Prospective questionnaire reported SARS-CoV-2 antibody serological Smokers Symptom symptomatic patient Symptomatic patients syndrome T-cell T-cell immune response WHO severity score women [DOI] 10.3389/fimmu.2022.920627 PMC 바로가기