Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3 trial [PRIBIVAC]건강한 개인에서 다양한 COVID-19 백신 조합의 안전성 및 면역원성 평가: 무작위, 피험자 맹검, 대조 3상 시험을 위한 연구 프로토콜 [PRIBIVAC]Article Published on 2022-06-162022-09-11 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 antibodies antibody approval best blood sample Blood samples BNT162b2 boost booster booster dose booster vaccinations cellular Cellular immune response collected Combination Comprehensive control arm Controlled clinical trial CoronaVac country COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines demonstration different time point different time points dose Effectiveness Eligible participants Endpoint enrolment evade excluded group healthy Heterologous homologous host immunity humoral immune immune profiling immune response Immunity Immunocompromised immunogenicity Immunoglobulin immunoglobulins Inactivated vaccine Infection Intervention intervention arm Laboratory test Laboratory tests Local maintain mRNA mRNA vaccine mRNA-1273 omicron over parameters participant performed persistence phase Phase 3 phase 3 trial physical population immunity pregnant primary endpoint Probability quantity raising randomization Randomized Randomized controlled trial regimen Regulatory SARS-CoV-2 SARS-COV-2 infection Serious Adverse Event Serious Adverse Events Singapore Study protocol vaccination Vaccine vaccine availability vaccine booster vaccine candidate variants variants of concern volunteers wildtype [DOI] 10.1186/s13063-022-06345-2 PMC 바로가기 [Article Type] Article
A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs숙주 miRNA를 사용하여 orf8 유전자의 보존된 대체 예비를 억제함으로써 SARS-CoV-2 복제를 표적으로 하는 생물정보학적 접근Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] adopted approach binding affinity causative agent compensating conserved COVID-19 COVID-19 pandemic deleting docked exhibit functional gene sequence gene silencing Genes homology Host host immunity host miRNA Hypothesis indels Interaction miRNA miRNAs modulate molecular docking mRNA multiple mutation multiple mutations mutations omicron Omicron variant ORF7a ORF7a gene ORF8 ORF8 gene partial sequence responsible Result SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus screened sequence similarity the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach variant variants viral genome viral replication viral strain virus while wild type without affecting Wuhan [DOI] 10.1016/j.compbiomed.2022.105436 PMC 바로가기 [Article Type] Article
Using machine learning to predict COVID-19 infection and severity risk among 4510 aged adults: a UK Biobank cohort study Research Published on 2022-05-112022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 2019 coronavirus disease 95% CI age Antibody titer Antibody titers AUC baseline Biochemistry characteristic Cohort cohort study collected COVID-19 COVID-19 infection demographics downloaded Factor Factors Hospitalization host immunity Human Cytomegalovirus immune markers Infectious disease Linear Discriminant Analysis lipids Metrics Model participant pathogen predict profile public health risk risk factor sensitivity serology Severe infection severity specificity subset threshold UK biobank was used [DOI] 10.1038/s41598-022-07307-z [Article Type] Research
Rapid and Accurate Identification of SARS-CoV-2 Variants Using Real Time PCR AssaysReal Time PCR 어세이를 사용한 SARS-CoV-2 변이체의 빠르고 정확한 식별Article Published on 2022-05-102022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele Alpha B.1.1.7 B.1.351 B.1.617.2 Beta blinded Combination correlated COVID-19 COVID-19 pandemic Delta delta variant Diagnosis diagnostic testing disease severity E484K effort Epidemiology evade Gamma Genomic surveillance genotyping help host immunity identification Laboratory lack Lineage management Mutation N501Y omicron P.1 P681R Patient Patient management PCR positive primer Rapid real-time RT-PCR resource reverse transcription-PCR routine diagnostic testing RT-PCR S982A SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened Sequencing specimen specimens spike gene Surveillance susceptibility tested the SARS-CoV-2 Therapeutics These data time Transmissibility variant variants Viral variants WGS while whole-genome sequencing [DOI] 10.3389/fcimb.2022.894613 PMC 바로가기 [Article Type] Article
In Silico Analysis Predicts a Limited Impact of SARS-CoV-2 Variants on CD8 T Cell Recognition실리코 분석은 CD8 T 세포 인식에 대한 SARS-CoV-2 변이체의 제한된 영향을 예측합니다Article Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis antibody binding affinity bioinformatics bioinformatics & CD8 CD8 T cell CD8 T cell epitopes CD8 T cells Computational biology computational biology. Course COVID-19 pandemic Delta dominant variant epitope Epitopes HLA host immunity Immunity immunogenicity Impact infection with SARS-CoV-2 investigated Limited majority memory mutated Mutation new SARS-CoV-2 not altered pandemic predicted Protective raised Receptor binding Recognition reduced reported response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure sequence similarity specific mutation specific mutations Spike protein T cell T cell epitopes T cells the spike protein vaccination Vaccine variant variants [DOI] 10.3389/fimmu.2022.891524 PMC 바로가기 [Article Type] Article
Structural and functional impact by SARS-CoV-2 Omicron spike mutationsSARS-CoV-2 오미크론 스파이크 돌연변이에 의한 구조적 및 기능적 영향Article Published on 2022-04-262022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter antigenic antigenic structure cellular tropism coronavirus country CP: Molecular biology cryo cryo-EM dominant evade full-length functional host immunity host receptor membrane fusion Molecular biology mutations N-terminal domain Neutralizing antibodies not seen omicron Omicron variant other variants prevalent Protein Receptor-binding domain S protein SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus spike mutation Spike protein Structure the receptor-binding domain the S protein variant variants [DOI] 10.1016/j.celrep.2022.110729 PMC 바로가기 [Article Type] Article
Rapid and sensitive detection of SARS-CoV-2 variants in nasopharyngeal swabs and wastewaters비인두 면봉 및 폐수에서 SARS-CoV-2 변이체의 신속하고 민감한 검출Article Published on 2022-04-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Affect allelic appearance carried characterized clade clades containment strategies detect diffusion disease severity Effectiveness Evolution functional genomic genotypes Genotyping assay help host immunity house Interaction limit mutations Nasopharyngeal swab nasopharyngeal swabs new SARS-CoV-2 NGS poor quality Rapid SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Spread tested urgency variant Variation variations viral genome virus Virus evolution VOCs wastewater whole-genome sequencing [DOI] 10.1016/j.diagmicrobio.2021.115632 PMC 바로가기 [Article Type] Article
Evaluation of Spike Protein Epitopes by Assessing the Dynamics of Humoral Immune Responses in Moderate COVID-19중간 정도의 COVID-19에서 체액 면역 반응의 역학을 평가하여 스파이크 단백질 에피토프 평가Article Published on 2022-03-182022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] AbMap acute respiratory syndrome analyses Analysis antibody binding epitope Antigen Assessing caused change Characteristics Cohort comparable Comprehensive conserved coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated Diagnosis distribution domains Dynamics ELISA enzyme-linked immunosorbent epitope genomic region homotrimer Hospitalization Hospitalized host immunity humoral humoral immune response IgG IgG antibody IgM immune immune system Immunotherapy in viral Infection information Microarray Moderate COVID-19 Novel coronavirus pandemic Patient peptide peptide microarray peptides provided random reactivity recombinant response S protein S protein epitope S proteins S1 protein SARS-CoV-2 serum sample Seven spike spike gene sequence Spike protein suggested symptom onset the S protein Vaccine development were used [DOI] 10.3389/fimmu.2022.770982 PMC 바로가기 [Article Type] Article
Predicting the mutational drivers of future SARS-CoV-2 variants of concern우려되는 미래 SARS-CoV-2 변이체의 돌연변이 동인 예측Article Published on 2022-02-232022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] advance Affect Amino acid antibodies applied approach Behavior binding Causal structure contribute covariate driver Effect Efficacy elevated epidemiological Epidemiology Evidence Evolution feature genomic high accuracy host immunity immunology IMPROVE Influenza Mutation natural infection natural infection-derived immunity omicron pandemic pathogen Pathogens predict Predictive Predictive value protein sequence public health Receiver operator characteristic SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variant shifting Spread surveillance data tested therapeutic therapeutic antibodies Transmissibility Vaccine variants of concern viral fitness viruses waned [DOI] 10.1126/scitranslmed.abk3445 PMC 바로가기 [Article Type] Article
Severe Thrombocytopenia as a Manifestation of COVID-19 InfectionReview Published on 2022-02-182022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress Asymptomatic bleeding change clinical manifestation Comorbidities Comorbidity Corticosteroid COVID-19 COVID-19 infection Deterioration diagnose disease Disseminated intravascular coagulation failure hematological High dose host immunity immune response Immune thrombocytopenia immunosuppressive Infection manifestation Obstructive Patient patients with COVID-19 Pneumonia risk severe complications severe thrombocytopenia severity thrombocytopenia thrombotic disorder Viral load virus [DOI] 10.3390/jcm11041088 PMC 바로가기 [Article Type] Review