hub genes – Page 2 – Communicable Diseases Research

Blood transcriptome analysis revealed the crosstalk between COVID-19 and HIV

Article

Published on 2022-10-282023-07-10
Journal: Frontiers in Immunology [Category] COVID19(2023년),

Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflow

Article

Published on 2022-10-012022-11-16
Journal: Functional & integrative genomics [Category] meta-analysis,

[키워드] Analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes upregulated utility
[DOI] 10.1007/s10142-022-00881-5 PMC 바로가기

Organ-specific host differential gene expression analysis in systemic candidiasis: A systems biology approach

전신 칸디다증에서 기관 특이적 숙주 차등 유전자 발현 분석: 시스템 생물학 접근법

Article

Published on 2022-08-012022-09-11
Journal: Microbial pathogenesis [Category] 유전자 메커니즘,

[키워드] acquisition Activation acute phase response Analysis approach C. albicans can be used Candida Candida albican Candida albicans Candidemia candidiasis Clinical management Co-infection Complication coronavirus disease COVID-19 COVID-19 infections COVID-19 mortality Critical Defense defense mechanisms develop Differential gene expression differentially expressed gene Differentially expressed genes down-regulated drug effector cells event fungal infections hospital Host hub genes human gene human genes Immune cell immune cells immune response immune responses Infection Interaction invasive involved iron kidney leukocyte liver lymphocyte mechanisms molecular mycotic infection mycotic infections occur organ organ-specific organs pathway proliferation protocol recruitment research finding risk Scientific community severe COVID-19 infections sluggish spleen Surveillance systemic Candidiasis Systems biology therapeutic therapy yeast
[DOI] 10.1016/j.micpath.2022.105677 PMC 바로가기 [Article Type] Article

Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndrome

COVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석

Article

Published on 2022-07-262022-09-11
Journal: Frontiers in Immunology [Category] 유전자 메커니즘,

[키워드] Analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS
[DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article

Screening the hub genes and analyzing the mechanisms in discharged COVID-19 patients retesting positive through bioinformatics analysis

생물정보학 분석을 통해 퇴원한 코로나19 환자 재검사에서 허브 유전자 스크리닝 및 기전 분석

Article

Published on 2022-07-012022-09-11
Journal: Journal of Clinical Laboratory Analysis [Category] 유전자 메커니즘,

[키워드] ALKBH6 AMBRA1 Analysis analyzed ANAPC1 Apoptosis ATP1A1 ATP1A1-AS1 bioinformatics Bioinformatics analysis convalescent COVID-19 COVID-19 patient COVID-19 patients cytoHubba differentially expressed gene discharge discharged DISP1 DOCK4 down-regulated down-regulated gene enrichment analysis expression data FAM149B1 FAM241B Gene Expression Omnibus Gene ontology Genes genomes GEO healthy control hub genes IGLV1-40 immune immune response KEGG Kyoto LRRC69 management mechanism MICAL3 Microarray MIR1249 mRNA Pathogenesis Patient patients PLPPR2 positive PPI PPI network Prognosis prognostic protein-protein interaction PSMG1 R software Rab11b RAB11B-AS1 retesting positive after discharged. Ribonucleic acid risk screened Screening selected significant enrichment SNRPD1 SNRPD2 SORT1 TP53BP1 TRAV18 two group two groups up-regulated virus was performed
[DOI] 10.1002/jcla.24495 PMC 바로가기 [Article Type] Article

SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic Cats

SARS CoV-2(Delta Variant) 감염 역학 및 국내 고양이의 면역 병인 발생

Article

Published on 2022-06-012022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2-expressing cell ACE2-expressing cells acute COVID-19 acute infection animal model animal models B.1.617.2 chemokine chemokine signaling circulating Clinical sign Cluster correlated correlation COVID-19 disease COVID-19 disease course Critical cytokine receptor Delta delta variant develop differentially expressed gene Differentially expressed genes disease Disease progression disease transmission Divergence domestic cats dose downstream dysregulated evaluate feline ferrets flexible genetic modification help highlight Host hub genes identify immunopathology include Infection Infectious virus Inflammatory inflammatory pathways inoculated Interaction interactions intranasally Kinetics lesion lesions limitation lung lung tissue Lungs Mild nasal network analysis non-human primates pathology pathway peribronchial Pneumocytes Post-infection Prevent progression pulmonary inflammation pulmonary lesion pulmonary lesions Respiratory disease RNA sequencing SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secretion significantly Spread target therapeutic timepoints transgenic mice translational upregulation variant Vascular endothelium Vasculitis Viral antigen Viral protein virus WGCNA wild-type SARS-CoV-2
[DOI] 10.3390/v14061207 PMC 바로가기 [Article Type] Article

Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients

간세포암 환자에서 SARS-CoV-2 감염에 대한 표적 및 약물 예측

Article

Published on 2022-05-312022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Cell clinician Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical dataset datasets differentially expressed differentially expressed gene drug drugs effective effective drug effective drugs epithelial cell functional genomes HCC HCC patient HCC patients Hepatocellular carcinoma hub genes Human identify Ilomastat infected with SARS-CoV-2 Interaction Kyoto lung epithelial microRNA MicroRNAs miRNA molecular Ontology pandemic pathway Patient patients Protein protein-protein interaction provide Research reveal SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 synergistic synergistic effect target terminology therapeutic transcription factor transcriptomic analysis Treatment was performed with COVID-19
[DOI] 10.1371/journal.pone.0269249 PMC 바로가기 [Article Type] Article

Identification of Diagnostic Gene Markers and Immune Infiltration in Systemic Lupus

전신성 루푸스에서 진단 유전자 마커 및 면역 침윤의 식별

Article

Published on 2022-05-102022-09-11
Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 바이오마커, 치료기술,

[키워드] Activation advancement Analysis analyzed Atypical autoantibodies autoantibody Autoantigens Autoimmune disease B cells bioinformatics Biomarker Central nervous system characteristic clinical manifestation clinical manifestations Clinical practice coexpressed coexpression network complexes control group coronavirus coronavirus disease correlation COVID-19 current DEGs determine Diagnosis diagnostic differentially expressed gene Differentially expressed genes disease downloaded downregulated Endocrine endocrine system enrichment analysis etiology evaluate expression data Factors fraction functional gene expression profile Genes Genetic GEO database healthy control healthy controls help heterogeneous highest hub genes human body identification identify Immune cell immune cells Immune complexes immune function Infection Interaction joints KEGG kidney leukemia Lupus lupus erythematosus miRNA multiple organs Participation Pathogenesis pathway Pathways Patient patients performed Population Potential biomarker potential biomarkers PPI PPI network protein-protein interaction receiver operating characteristic recognize regulatory network Research resulting ribosome ROC ROC Curve RPL19 RPS17 RPS19 RPS7 selected skin SLE SLE patient SLE patients Symptom systemic systemic lupus erythematosus T cell T cells the disease the healthy transcription factor Treatment turquoise module upregulated variety virus was selected was used weighted gene coexpression network analysis WGCNA whole blood sample
[DOI] 10.1155/2022/3386999 PMC 바로가기 [Article Type] Article

Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related Stroke

COVID-19 관련 뇌졸중의 잠재적 생물학적 과정 및 주요 유전자를 식별하기 위한 가중 유전자 공동 발현 네트워크 분석

Article

Published on 2022-05-092022-09-11
Journal: Oxidative Medicine and Cellular Longevity [Category] 유전자 메커니즘,

Bioinformatics and System Biology Approach to Identify the Influences of COVID-19 on Rheumatoid Arthritis

류마티스 관절염에 대한 COVID-19의 영향을 식별하기 위한 생물정보학 및 시스템 생물학 접근

Article

Published on 2022-04-072022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach Arthritis association bioinformatics Biology candidate drug condition coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dataset datasets DEGs differentially expressed differentially expressed gene Differentially expressed genes drug drug molecule functional functional enrichment generate hub genes identify Infection influence interactions mechanism molecular mechanism molecular mechanisms Mortality ontological Pathway analysis performed potential molecular PPI PPI network progression protein-protein interaction proteinprotein interaction rapid increase Rheumatoid rheumatoid arthritis SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease statistical System Systems biology targeted therapy Transcription transcription factor Treatment were used
[DOI] 10.3389/fimmu.2022.860676 PMC 바로가기 [Article Type] Article