Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donorsCOVID-19 환자, 의료 종사자 및 회복기 혈장 기증자의 SARS-CoV-2 급증에 대한 중화 항체Technical Advance Published on 2020-11-192022-09-12 Journal: JCI Insight [Category] SARS, 진단, [키워드] antibody Antibody testing Cellular immune response cohorts convalescent plasma COVID-19 COVID-19 pathogenesis COVID-19 patients COVID-19 symptoms Donor donors Efficacy evaluate followed by glycoprotein HCWs Health care Health care worker health care workers highest highlight HIV-1 hospitalized patients human antibody response ICU ICU Patients individual individuals intensive care intensive care unit intron lentiviral lentivirus Neutralization assay neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Patient phenotypic phenotypic variation pseudotype pseudotyped Rapid reporter SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 strain secreted serological survey Serological surveys serum the SARS-CoV-2 Treatment Variation Virus neutralization was used [DOI] 10.1172/jci.insight.143213 PMC 바로가기 [Article Type] Technical Advance
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patientsReports Published on 2020-10-082022-10-28 Journal: Science Immunology [Category] COVID-19, MERS, SARS, [키워드] Anti-RBD IgG anti-S antibody blood sample circulating coronavirus correlated COVID patient COVID-19 patient cross-reactivity demonstrated help HKU1 Hospitalization human antibody response IgA IgA response IgG IgG antibody IgG response IgM IgM antibody individual infected individual infected with SARS-CoV-2 Infection infections isotypes tested marker median time Neutralizing antibodies neutralizing antibody titers NL63 no decrease North OC43 Older pandemic Patient plasma Protein RBD Receptor binding domain required response SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein sensitivity Seroconversion seropositive individual serum antibody response short-lived specificity symptom onset the median the receptor-binding domain the SARS-CoV-2 threshold while [DOI] 10.1126/sciimmunol.abe0367 PMC 바로가기 [Article Type] Reports
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patientsArticle Published on 2020-06-012022-10-04 Journal: Nature Communications [Category] SARS, 진단, 치료기술, 치료법, [키워드] Alter antibodies antibody B-cell B-cell epitope coronavirus COVID-19 convalescent patients COVID-19 patient diagnostic diagnostics elicit fusion peptide help human antibody response identify IgG immunodominant immunogenic linear linear epitope neutralising neutralising antibody overlapping Patient peptides Receptor binding domain Region SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein sera serological test serology significantly spike glycoprotein Spike protein target targets the SARS-CoV-2 vaccine candidate Vaccine development Vaccines viral infection Virus neutralisation [DOI] 10.1038/s41467-020-16638-2 PMC 바로가기 [Article Type] Article
Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common VirusesHLA 클래스 II 단백질의 아미노산 변이는 일반적인 바이러스에 대한 체액 반응의 주요 결정 요인입니다Report Published on 2015-11-052022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] acid affecting Amino acid amino acid residue Antigen association Autoimmune disease Autoimmune diseases causal variant chromosome chromosome 6 class common complex determinant EBV Epstein-Barr virus Genome-wide association studies Genome-wide association study HLA HLA class II HLA class II variation HLA-DRβ1 haplotype HLA-DRβ1 haplotypes human antibody response human genetic contribution humans humoral humoral immune response Humoral response humoral-response regulation immunocompetent adults Immunoglobulin Immunoglobulin G immunoglobulin G response Influenza influenza A influenza A virus JC polyomavirus leucocyte Local magnitude Major major histocompatibility complex Merkel cell Merkel cell polyomavirus modulation overlap pathogen-specific role pathogenic virus pathogenic viruses performed Protein response Significant the major histocompatibility these viruses Variability variant variants Variation Viral Viral antigen viral antigens virus virus-specific pattern virus-specific patterns viruses [DOI] 10.1016/j.ajhg.2015.09.008 PMC 바로가기 [Article Type] Report