Identification of characteristics frequency and hot-spots in protein sequence of COVID-19 diseaseResearch article Published on 2022-09-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 치료기술, [키워드] ACE-2 amino-acid Bandpass carried Characteristics COVID-19 COVID-19 disease detection system EDA Frequency globe hardware help Hot-spots identification human cell human cells identification IIR digital filter implementation IMPROVE Interaction MATLAB Protein protein sequence Proteins S-protein SARS CoV-2 SARS CoV2 synthesis transmitted understanding Vaccine development variant virus Xilinx [DOI] 10.1016/j.bspc.2022.103909 [Article Type] Research article
AntiV-SGN: a universal antiviral strategy to combat both RNA and DNA viruses by destroying their nucleic acids without sequence limitationArticle Published on 2022-09-012022-11-15 Journal: Microbial Biotechnology [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral can be used cells composed demonstrated DNA and RNA DNA virus expression feasibility FEN1 Genome HBV Host human cell mutate nucleic acid Numerous PAM Pathogens Protein protospacer adjacent motif provided reduce RNA SARS-CoV-2 sequence significantly target variety Vero Cell viral DNA viral outbreak virus viruses was tested were infected [DOI] 10.1111/1751-7915.14076 PMC 바로가기
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA microRNA. Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2In-silico 스크리닝 및 in-vitro assay는 SARS-CoV-2에 대한 Indomethacin의 항바이러스 효과를 보여줍니다Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analysis analyzed anti-inflammatory drug Antiviral effect applied can be used caused cellular Comparative Compound compounds Computational drug coronavirus coronavirus disease COVID-19 CTD death Differential gene expression drug drug candidate drug candidates Drug repurposing epithelial cell epithelial cells Gene Expression Host host response human cell human cells human lung human lung epithelial cells humans in-silico In-vitro in-vitro assay indomethacin Infection investigated moderate molecules mRNA expression profile nonsteroidal anti-inflammatory drug Perspective Protein responsible SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread tested the SARS-CoV-2 therapeutic Toxicogenomics treat Treatment Vaccine Vero CCL-81 cell Vero CCL-81 cells viral infection Virtual screening virtual screening. Vitamin was performed [DOI] 10.1016/j.compbiomed.2022.105788 PMC 바로가기 [Article Type] Article
Vaccine based on folded receptor binding domain-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variantsSARS-CoV-2 변이체에 대한 살균 면역을 유도할 수 있는 접힌 수용체 결합 도메인-PreS 융합 단백질 기반 백신Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody Response Antigen C-terminus carrier cellular combination vaccine construction convalescent coronavirus COVID-19 COVID-19 pandemic fused fusion protein Genetic genotypes HBV healthy subject healthy subjects hepatitis B Hepatitis B virus human cell human cells IgG IgG antibodies IgG antibody IgG response Immunity immunized in vitro in vivo induce inhibited Interaction maintenance median mucosal secretions Neutralizing Neutralizing antibodies neutralizing antibody neutralizing titers Omicron variant pandemic Protein random Random sample RBD RBD-specific IgG RBD-specific IgG response receptor ACE2 Receptor binding Receptor-binding domain recombinant fusion protein Registered replicate respiratory response responsible robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies specific IgG antibodies spike Spike protein sterilizing immunity subject subjects subunit Subunit vaccine surface antigen sustained Vaccine vaccine. Viral viral replication virus entry virus-neutralizing VNT [DOI] 10.1111/all.15305 PMC 바로가기 [Article Type] Article
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety. SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatmentResearch article Published on 2022-07-062022-10-05 Journal: Molecular Therapy [Category] 바이오마커, 변종, 임상, 치료기술, 치료법, [키워드] ACE2 activity/concentration biomarker in plasma/saliva Corona virus COVID-19 disease RAS pathway soluble Angiotensin-Converting Enzyme 2 ACE2 acute respiratory syndrome age angiotensin-converting-enzyme Autopsy Biomarker clinical observation Concentration condition Control convalescent coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient disease disease severity dysregulation evaluate evaluated Hospitalization hospitalized COVID-19 patient human cell infect inverse correlation lung mACE2 marker membrane nadir no difference Non-COVID-19 offer Patient patients plasma Plasma marker plasmas quantitative test quarantine receptor reduced renin-angiotensin system restored sACE2 Saliva saliva marker SARS-CoV-2 SARS-CoV-2 diagnosis/treatment soluble ACE2 statistically therapeutic target tissue treat variations volunteers [DOI] 10.1016/j.omtm.2022.07.003 [Article Type] Research article
Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2SARS-CoV-2의 약물 가능한 인간 숙주 세포 표적에 대한 유망한 치료제로서 선택된 아프리카 식물의 식물 화합물의 분자 모델링 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome coronavirus African Amino acid amino acid residue angiotensin Angiotensin converting enzyme-2 bafilomycin binding binding energy candidate drug cathepsin cathepsin L caused Cell clinical evaluation clinical evaluations Compound compounds Computational methods coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical enzyme galactoside hACE2 highly pathogenic host cell Host cell targets human cell human cells human host in vitro inhibitor inhibitors of TMPRSS2 inhibitory inhibitory action investigated kaempferol mechanism MLN-4760 Modification modifications modulate molecular dynamics Molecular dynamics simulation myricetin nafamostat Phytocompounds Protein Proteins Replication Research respiratory Respiratory disease respiratory diseases rutinoside SARS-CoV-2 SARS-CoV-2. selected Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structural analysis subjects subsequent target Therapeutic benefit these compound these compounds TMPRSS2 transmembrane serine protease Verbascoside viral entry viral spike protein viral spike proteins while [DOI] 10.1016/j.jmgm.2022.108185 PMC 바로가기 [Article Type] Article
A novel high-throughput single B-cell cloning platform for isolation and characterization of high-affinity and potent SARS-CoV-2 neutralizing antibodies고친화도 및 강력한 SARS-CoV-2 중화 항체의 분리 및 특성화를 위한 새로운 고처리량 단일 B 세포 클로닝 플랫폼Article Published on 2022-07-012022-09-12 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE-2 receptor antibody B-cell binding Blood coronavirus COVID-19 Critical diagnosing Diseases domain effective ELISA high affinity highlight human cell Isolation mAb mAbs mAbs. Neutralizing Neutralizing activity neutralizing antibody Patient platform RBD RBD domain reporter S1 subunit SARS-CoV-2 SARS-CoV-2 neutralizing antibody single B cell Single B-cell cloning SPR Strategy the RBD the spike protein was used Wuhan-Hu-1 [DOI] 10.1016/j.antiviral.2022.105349 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron Variant Binds to Human Cells More Strongly than the Wild Type: Evidence from Molecular Dynamics SimulationSARS-CoV-2 오미크론 변이체는 야생형보다 더 강력하게 인간 세포에 결합합니다: 분자 역학 시뮬레이션의 증거Article Published on 2022-06-302022-09-11 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin B.1.1.529 bind binding affinities binding affinity binding free energy calculated comparable complex computational studies Computational study contagious coronavirus COVID-19 pandemic Critical distribution domain Dynamics electrostatic interaction ENhance examined free energy glycan glycans hACE2 heterogeneous homogeneous Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human cell human cells infection rate Interaction molecular molecular dynamics Molecular dynamics simulation Molecular mechanics Mutation omicron Omicron variant Open problem pandemic RBD Receptor binding domain reported residue SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Simulation Spike protein stability surface area T478K the binding affinity the RBD variant viral RBD wild type [DOI] 10.1021/acs.jpcb.2c01048 PMC 바로가기 [Article Type] Article