Identification of characteristics frequency and hot-spots in protein sequence of COVID-19 diseaseResearch article Published on 2022-09-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 치료기술, [키워드] ACE-2 amino-acid Bandpass carried Characteristics COVID-19 COVID-19 disease detection system EDA Frequency globe hardware help Hot-spots identification human cell human cells identification IIR digital filter implementation IMPROVE Interaction MATLAB Protein protein sequence Proteins S-protein SARS CoV-2 SARS CoV2 synthesis transmitted understanding Vaccine development variant virus Xilinx [DOI] 10.1016/j.bspc.2022.103909 [Article Type] Research article
Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infectionArticle Published on 2022-09-012022-11-16 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, [키워드] acetylated binding BRD4 bromodomain bronchial epithelial cells C-terminus contribute decrease domain drug resistance E protein envelope E protein. ET domain human cells in vivo Infection JQ1 lung mechanism molecular mechanism motif OTX015 pharmacological target recognize SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis the SARS-CoV-2 transcriptional regulator variants of SARS-CoV-2 virus [DOI] 10.1016/j.str.2022.05.020 PMC 바로가기
RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human CellsArticle Published on 2022-08-312023-06-22 Journal: International Journal of Molecular Sciences [Category] 조류인플루엔자, [키워드] Avian influenza virus circular RNA human cells replication. RNA sequencing [DOI] 10.3390/ijms23179901 PMC 바로가기
An intranasal ASO therapeutic targeting SARS-CoV-2SARS-CoV-2를 표적으로 하는 비강내 ASO 치료제Article Published on 2022-08-032022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] administration antibody immunity Antisense oligonucleotide ASO binding complement conserved coronavirus COVID-19 COVID-19 pandemic Daily decrease disrupt Efficacy effort evade help higher infectivity human cells identify in vitro in vivo infected individuals Inhaled intranasal leader sequence lung Lungs mice new SARS-CoV-2 Non-invasive nucleic acid Pandemics Prevent preventing infection Rapid reduce RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequence severity of COVID-19 suppresse tested the SARS-CoV-2 therapeutic Therapeutic approach therapeutic strategy therapeutic targeting tide Transmission turn vaccination Vaccine variant Viral viral replication Viral RNA [DOI] 10.1038/s41467-022-32216-0 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma면역 침윤과 관련된 FURIN은 SARS-CoV-2 감염 관련 폐 선암에서 잠재적인 바이오마커 역할을 합니다Article Published on 2022-08-012022-09-11 Journal: Clinical and experimental medicine [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adenocarcinoma Affect Bioinformatics analysis Biomarker can be used Cancer cancers coronavirus correlated database databases estimation expressed expression expression of SARS-CoV-2 furin FURIN expression Gene Expression Omnibus GEO human cells immune Immune cell immune cells immune infiltration Kaplan-Meier lung adenocarcinoma Macrophage marker mechanism Patient patients performed Profiling Prognosis Prognostic value Protein respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severe acute respiratory syndrome Coronavirus significantly survival Tumor variety [DOI] 10.1007/s10238-021-00760-6 PMC 바로가기 [Article Type] Article
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2In-silico 스크리닝 및 in-vitro assay는 SARS-CoV-2에 대한 Indomethacin의 항바이러스 효과를 보여줍니다Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analysis analyzed anti-inflammatory drug Antiviral effect applied can be used caused cellular Comparative Compound compounds Computational drug coronavirus coronavirus disease COVID-19 CTD death Differential gene expression drug drug candidate drug candidates Drug repurposing epithelial cell epithelial cells Gene Expression Host host response human cell human cells human lung human lung epithelial cells humans in-silico In-vitro in-vitro assay indomethacin Infection investigated moderate molecules mRNA expression profile nonsteroidal anti-inflammatory drug Perspective Protein responsible SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread tested the SARS-CoV-2 therapeutic Toxicogenomics treat Treatment Vaccine Vero CCL-81 cell Vero CCL-81 cells viral infection Virtual screening virtual screening. Vitamin was performed [DOI] 10.1016/j.compbiomed.2022.105788 PMC 바로가기 [Article Type] Article
Vaccine based on folded receptor binding domain-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variantsSARS-CoV-2 변이체에 대한 살균 면역을 유도할 수 있는 접힌 수용체 결합 도메인-PreS 융합 단백질 기반 백신Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody Response Antigen C-terminus carrier cellular combination vaccine construction convalescent coronavirus COVID-19 COVID-19 pandemic fused fusion protein Genetic genotypes HBV healthy subject healthy subjects hepatitis B Hepatitis B virus human cell human cells IgG IgG antibodies IgG antibody IgG response Immunity immunized in vitro in vivo induce inhibited Interaction maintenance median mucosal secretions Neutralizing Neutralizing antibodies neutralizing antibody neutralizing titers Omicron variant pandemic Protein random Random sample RBD RBD-specific IgG RBD-specific IgG response receptor ACE2 Receptor binding Receptor-binding domain recombinant fusion protein Registered replicate respiratory response responsible robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies specific IgG antibodies spike Spike protein sterilizing immunity subject subjects subunit Subunit vaccine surface antigen sustained Vaccine vaccine. Viral viral replication virus entry virus-neutralizing VNT [DOI] 10.1111/all.15305 PMC 바로가기 [Article Type] Article
Urtica dioica Agglutinin: A plant protein candidate for inhibition of SARS-COV-2 receptor-binding domain for control of Covid19 InfectionUrtica dioica Agglutinin: Covid19 감염 통제를 위한 SARS-COV-2 수용체 결합 도메인 억제를 위한 식물성 단백질 후보Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antiviral effect average bind binding binding affinity binding energy binding free energy binding site calculated Cell complex convalescent serum coronavirus docked docking docking result docking results domain Donor donors dynamic effective effective drug effective drugs ELISA ELISA assay enzyme exhibited free energy Gromacs host cell human cells IgG Infection inhibit inhibitory activity Interaction limitation MD simulation mechanism Medicine Medicines MTT Mutation peptide Prevent Previous studies Protein RBD RBD binding RBD complex RBD protein Receptor-binding domain Result S-protein Safe SARS-CoV SARS-CoV-2 Simulation spike Spike protein spike protein of SARS-CoV-2 stability the cell the RBD Toxicity Urtica Vaccine virus was performed was used [DOI] 10.1371/journal.pone.0268156 PMC 바로가기 [Article Type] Article
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety. SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article