Human coronaviruses: The emergence of SARS-CoV-2 and management of COVID-19Review article Published on 2022-10-012022-10-05 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] acute respiratory syndrome circumvent coronavirus coronavirus disease COVID-19 Cross-species transmission deaths disease severity global pandemic Healthcare system highlight Human human coronavirus human coronaviruses implication Infection Long COVID management Mutation Respiratory pathogens SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seven Strains transmission of SARS-CoV-2 Treatment Vaccines variants of concern zoonotic transmission [DOI] 10.1016/j.virusres.2022.198882 [Article Type] Review article
Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profileArticle Published on 2022-09-272022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] 229E antibodies antibody Barcelona Blood blood sample C-terminus cause chemokine collected Concentration concentrations COVID-19 cytokine level cytokine levels cytokine profile cytokine response Cytokines distress domain EGF FGF full-length growth factor higher risk HKU1 human coronavirus Humoral response IFN-α IgA level IgG IgM IL-15 IL-17 IL-7 immune response immunological increased risk induce Infection Inflammatory investigated male Maternal maternal and neonatal immunity mother Neonatal Newborn NL63 non-infected nucleocapsid OC43 outcome outcomes positive positive correlation positive for rRT-PCR Pregnancy pregnant women Preterm birth profiles Questionnaires RANTES recruited reduction robust rRT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs serology severe COVID-19 Spain Swab Symptom symptomatic tested transfer transplacental transfer. Vaccines variables was increased were infected were recorded women [DOI] 10.3389/fimmu.2022.999136 PMC 바로가기
mRNA vaccination drives differential mucosal neutralizing antibody profiles in naïve and SARS-CoV-2 previously-infected individualsArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] 95% CI ACE2 ACE2 Inhibition addition antibody Antibody responses Beta coronaviruses binding BNT162b2 vaccine Breakthrough infection characterized contribute cross-reactive Defense dose healthcare worker HKU1 human coronavirus humoral IgA IgA response IgG IgG level IgG response immunoassay individual individuals induce infected with SARS-CoV-2 investigated less Meso Scale Discovery mRNA mRNA vaccination mRNA vaccine mucosal mucosal immune mucosal immunity multiplex naïve neutralizing antibody neutralizing response neutralizing responses neutralizing responses. OC43 of BNT162b2 participant Participants pathogenic plasma positively correlated profile response SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2-specific IgG second dose selected sensitivity Spearman spike-specific IgG Transmission vaccination vaccine dose variants of concern [DOI] 10.3389/fimmu.2022.953949 PMC 바로가기
Are higher antibody levels against seasonal human coronaviruses associated with a more robust humoral immune response after SARS-CoV-2 vaccination?Article Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] adjusted affected age anti-spike antibodies anti-spike antibody anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody antibodies antibody Antibody concentrations antigens appear association baseline Blood Canada coronavirus coronavirus Correlation analysis COVID-19 COVID-19 infection COVID-19 testing demonstrated determine Endemic HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 human coronavirus human endemic coronaviruses humoral immune response IgG levels Immunity include increases in linear relationship Multiple regression multiple regression model not affect Observational cohort study participant Participants performed positive provided questionnaire data robust Sample SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 vaccines Scatter plot significant difference significantly higher tested vaccinated individual vaccination vaccination. [DOI] 10.3389/fimmu.2022.954093 PMC 바로가기
FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronavirusesArticle Published on 2022-09-012022-11-15 Journal: Journal of Lipid Research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Cell click chemistry conserved coronavirus CoV CoV-229E Critical cysteine de novo enzyme epithelial cells examined expressed FASN fatty Fatty acid host cell Host cell entry human coronavirus in vitro incubated Infection inhibited inhibitor isoform Modification modify Multiple other coronavirus palmitate phylogenetically Prevent Protein reduction in reported residues S-acylation SARS-CoV-2 specificity spike coronavirus. Spike protein Spread the spike protein ZDHHC ZDHHC5 [DOI] 10.1016/j.jlr.2022.100256 PMC 바로가기
IgG Against Human Betacoronavirus Spike Proteins Correlates With SARS-CoV-2 Anti-Spike IgG Responses and COVID-19 Disease SeverityArticle Published on 2022-08-262022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome Against anti-S anti-S antibody anti-S2 anti-SARS-CoV-2 antibody Anti-spike antibody Antibody Response bidirectional cohorts common cold common cold human coronaviruses (HCoVs) coronavirus correlated COVID-19 cross-react cross-reactive antibody cross-reactive antibody response decrease disease disease severity domain Effect elicited HKU1 homologous Human human coronavirus IgG IgG antibody immune immune imprinting. Immunoglobulin morbidity and mortality Multiplex assay OC43 Organ failure Protective RaTG13 recognizing response S proteins S1-reactive antibodies SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection sera serum sample severe coronavirus disease Severity of disease significantly increased SOFA spike strain subject with COVID-19 [DOI] 10.1093/infdis/jiac022 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Boosts Neutralizing Activity Against Seasonal Human Coronaviruses중증 급성 호흡기 증후군 코로나바이러스 2 백신 접종은 계절성 인간 코로나바이러스에 대한 중화 활성을 향상시킵니다Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료법, [키워드] 229E activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against analyzed average BNT162b2 causative agent ChAdOx1 ChAdOx1 nCoV-19 circulating colds common cold Concentration coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccinations cross-neutralization cross-protection determined by Efficiency Endemic Gene Expression HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs Heterologous Huh-7 cells Human human coronavirus incubated individual inhibitory activity MERS MERS-CoV Middle East Middle East respiratory syndrome MOST neutralization neutralize Neutralizing activity NL63 nucleocapsid expression OC43 Preexisting immunity pseudoparticle pseudovirion pseudovirions reporter reporter gene respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 vaccination seasonal seasonal coronavirus seasonal coronaviruses seasonal coronaviruses. sera severe acute respiratory syndrome Coronavirus significantly increased Spike proteins these viruses vaccination Viral RNA virus [DOI] 10.1093/cid/ciac057 PMC 바로가기 [Article Type] Article
Human coronaviruses disassemble processing bodiesArticle Published on 2022-08-232022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] 229E caused cells characteristic common cold CoVs contribute coronavirus Coronavirus infection correlated CoVs cytokine cytoplasmic dysregulated dysregulation expression FIVE fluorescent Granule Human human coronavirus IL-6 immune response impacted infected cell Infection information innate immune response mechanism MERS mRNA transcripts NL63 OC43 processing Proinflammatory cytokine proinflammatory cytokines promote Protein respond responsible ribonucleoprotein RNA RNAs SARS-CoV SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein screened severe SARS-CoV-2 stability submission the N protein the viral nucleocapsid TNF transcript translation unique viral infection virus [DOI] 10.1371/journal.ppat.1010724 PMC 바로가기
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts에센셜 오일 및 방향족 추출물의 anti-SARS-CoV-2 특성 평가Article Published on 2022-08-202022-09-11 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] anti-SARS-CoV-2 Antiviral available data Coronaviruses COVID-19 outbreak develop Effectiveness Essential exploratory study growth highly pathogenic human coronavirus inhibitory knowledge long term Papain Papain-like protease protease inhibitors Proteases SARS-CoV-2 therapeutic strategy [DOI] 10.1038/s41598-022-18676-w PMC 바로가기 [Article Type] Article
Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2새로운 인간 코로나바이러스 SARS-CoV, MERS-CoV 및 SARS-CoV-2에 대한 면역 반응 유도를 위한 3가 서브유닛 백신을 설계하기 위해 높은 처리량 및 포괄적인 면역정보학 접근법 적용Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] acute respiratory syndrome added adjuvant against SARS-CoV analysis Antigen antigens applied Applying approach approach B-cell binding affinity codon optimization complex conducted coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs CTL defensin demonstrated disease docking epitope Epitopes facilitate HLA HTL HTLs human coronavirus IEDB IFN IFN-γ immune response immune responses immunogenic immunoinformatics In silico cloning increased expression kDa MDs membrane MERS MERS-CoV MERS‐CoV MHC I Middle East Middle East respiratory syndrome molecular dynamics Molecular dynamics simulation molecular weight molecule Multi-epitope vaccine non-allergenic non-structural protein nucleocapsid PADRE Pan predicted Protein responses SARS-CoV SARS-CoV-2 SARS‐CoV secondary selected epitope sequence sequences Severe acute respiratory syndrome stability stimulate Structure subunit Subunit vaccine Subunit vaccine. syndrome T lymphocyte TAT the vaccine trivalent Vaccine was used β-defensin [DOI] 10.1080/07391102.2021.1876774 PMC 바로가기 [Article Type] Article