Biflavonoids from Rhus succedanea as probable natural inhibitors against SARS-CoV-2: a molecular docking and molecular dynamics approachSARS-CoV-2에 대한 가능한 천연 억제제로서의 Rhus succedanea의 비플라보노이드: 분자 도킹 및 분자 역학 접근Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] affinity Antiviral antiviral activity approach Biflavonoid biflavonoids binding affinities binding affinity binding mode binding modes binding site Bioflavonoid catalytic catalytic site complexes Compound conformational coronavirus COVID-19 drug Drug development drugs effective vaccine Effective vaccines enzyme fluctuations highlight human population hydrophilic hydrophobic in viral in vitro in vivo inhibitor initial Interaction less molecular molecular docking molecular dynamic simulation molecular dynamic simulations molecular dynamics Molecular dynamics simulation molecular dynamics simulation. molecular interaction MPro Mpro protein outbreak Panic protease provide Replication reported researcher residues Rhus Rhus succedanea RNA viruses Safe SARS-CoV-2 SARS-CoV-2 Mpro therapeutic threat unavailability viral replication virus worldwide pandemic [DOI] 10.1080/07391102.2020.1858165 PMC 바로가기 [Article Type] Article
Human ACE2 Polymorphisms from Different Human Populations Modulate SARS-CoV-2 Infection다양한 인간 집단의 인간 ACE2 다형성이 SARS-CoV-2 감염을 조절합니다Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Asian caused cell entry receptor cells contrary coronavirus COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 symptom COVID-19 symptoms death determinant E35K ENCODE environmental factor Ethnic groups expression Genetic genetic determinant hACE2 high variability Host Human human ACE2 Human genome human population Infection modulate pandemic polymorphism Polymorphisms polymorphisms. Population populations PROTECT Protective protective effect reduced risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 severity of COVID-19 surface expression susceptibility Symptoms two allele Two alleles variant virus infection wild-type [DOI] 10.3390/v14071451 PMC 바로가기 [Article Type] Article
Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanismsSARS-CoV-2 M pro의 종합적인 피트니스 환경은 바이러스 저항 메커니즘에 대한 통찰력을 보여줍니다Article Published on 2022-06-202022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Amino acid amino acid changes amino acids analyzed Anti-viral drugs can be used cleave Complete Comprehensive conserved contribute Coronavirus-2 correlated Critical deep mutational scanning deep sequencing defined drug drug design drug resistance Effect effective elicit evade Evolution Evolutionary biology expression functional human population Infectious disease inhibitor inhibitors life cycle M pro main protease mechanism Microbiology Microbiology. MPro Mutation network new strain performed physically protease Protein reduced reveal S. cerevisiae SARS-CoV-2 SARS-CoV-2 main protease selection pressure Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Toxicity Vaccines variant viral life cycle Viral resistance virulent yeast [DOI] 10.7554/eLife.77433 PMC 바로가기 [Article Type] Article
Detection of Ancient Viruses and Long-Term Viral Evolution고대 바이러스의 탐지 및 장기간의 바이러스 진화Review Published on 2022-06-182022-09-11 Journal: Viruses [Category] 치료기술, [키워드] analyzed ancient DNA ancient RNA ancient virome ancient virus approach bioinformatics complex COVID-19 outbreak detectable detection events human population NGS Pandemics past pathogenic pathogenic virus pathogenic viruses PCR preserved recent RNA Sequencing specimen TDRP tissues unique Usage viral DNA viral evolution viral evolution. viral genome viral genomes virus [DOI] 10.3390/v14061336 PMC 바로가기 [Article Type] Review
Probiotics for Reduction of Examination Stress in Students (PRESS) study: A randomized, double-blind, placebo-controlled trial of the probiotic Lacticaseibacillus rhamnosus HN001Randomized Controlled Trial Published on 2022-06-082022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] Anxiety baseline benefit Compound COVID19 determine double-blind Evidence examination Factor groups highlight human population IMPROVE Intervention measure no significant difference outcomes pandemic Placebo placebo-controlled study placebo-controlled trial post-intervention Probiotics Psychological psychological health Psychological outcome Randomized reduced Stress student supplemented group trajectory Trial [DOI] 10.1371/journal.pone.0267778 PMC 바로가기 [Article Type] Randomized Controlled Trial
Exclusion of women from COVID-19 studies harms women’s health and slows our response to pandemicsCOVID-19 연구에서 여성 제외Review Published on 2022-06-082022-09-11 Journal: Biology of Sex Differences [Category] 변종, [키워드] approach clinical trial clinical trials consequence COVID-19 COVID-19 research exaggerate Gender Gender differences General health Health human population IMPROVE include Inclusion neglect pandemic Pandemics Public public health Research Sex difference sexual dimorphism Sexual dimorphism. Vaccine variant women [DOI] 10.1186/s13293-022-00435-1 PMC 바로가기 [Article Type] Review
Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics치료제로서의 최적 기능을 위한 Anti-SARS-CoV-2 단일클론항체 변형 전략 평가Article Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alleviate antibody Antibody-dependent enhancement caused Cell circulating closure Combination coronavirus country COVID-19 infection COVID-19 infections COVID-19 pandemic death disease Economy Effect epitope Epitopes Health crisis Human human population humoral immune response in vitro infecting investigated LALA lockdown mAb mAbs modify monoclonal antibodies monoclonal antibody Mutation neutralize produced public health crisis public health measure public health measures reduce reported respiratory resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 spike protein serum severe acute respiratory syndrome Coronavirus Spike protein Spread the antibody the disease the spike protein therapeutic option therapy These data Viral viral variant virus writing [DOI] 10.1371/journal.pone.0267796 PMC 바로가기 [Article Type] Article
Protein engineering responses to the COVID-19 pandemic코로나19 팬데믹에 대한 단백질 공학 대응Review Published on 2022-06-012022-09-11 Journal: Current opinion in structural biology [Category] COVID19(2023년), SARS, 변종, [키워드] Antigen breadth candidate COVID-19 COVID-19 pandemic COVID-19 vaccine develop display elicited glycoprotein High-resolution human population Humoral immunity nanoparticle neutralization potency other coronavirus other coronaviruses PROTECT researcher response robust SARS-CoV-2 variant SARS-CoV-2 variants Structure structure-based design Substitution vaccine candidate [DOI] 10.1016/j.sbi.2022.102385 PMC 바로가기 [Article Type] Review
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environmentsResearch article Published on 2022-06-012022-10-05 Journal: Life Sciences in Space Research [Category] 비임상, [키워드] accelerate addition adverse effect approach Biomarker Biomarkers Cancer Cancer patients cellular pathway chronic Critical develop Effect help human population Infectious disease Initially involved kill medical countermeasure Medical countermeasures NASA National Cancer Institute NIAID nuclear organization over overlapping physician Population PROTECT provided Radiation Radiation dose radiation exposure radiological reduce Research Space subject supported sustained terrestrial tissue tissues translation Treatment Tumor tumor cell tumors [DOI] 10.1016/j.lssr.2022.06.004 [Article Type] Research article
Understanding the Driving Forces That Trigger Mutations in SARS-CoV-2: Mutational Energetics and the Role of Arginine Blockers in COVID-19 TherapySARS-CoV-2에서 돌연변이를 유발하는 원동력 이해: 돌연변이 에너지와 COVID-19 치료에서 아르기닌 차단제의 역할Article Published on 2022-05-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] 3CLpro accelerated ACE2 ACE2 protein Alpha Amino acid amino acids angiotensin Angiotensin receptor blockers angiotensin type1 receptor Angiotensin-converting enzyme anionic antiviral drug arginine assist association Beta binding biphenyl bisartans blocker blockers candidate drug cleavage site cleavage sites complex complexes Computational approaches conformation conformational contribute COVID-19 COVID-19 therapy Critical Delta delta variant driving drug energetics ENhance equilibrium Evolution of SARS-CoV-2 force furin furin cleavage site Gamma human clinical trials human population hydrolysis hydropathy hydrophilic hydrophobic interaction in silico Infection Interaction interactions interface investigated Lambda molecular Molecular biology molecular dynamic simulations molecular dynamics mutant mutants mutate Mutation omicron Omicron variants pharmacophores polar Protein RBD RBD binding RBD-ACE2 receptor Receptor-binding domain referred to replacement Replication Research residue residues role S-protein salt salt bridges SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 virus Sartans. Spread suggested target targets tetrazole the RBD the receptor-binding domain the SARS-CoV-2 virus Therapies translation Treatment treatment of COVID-19 Trigger understanding variant variants viral infection virus wild-type virus π-π interaction [DOI] 10.3390/v14051029 PMC 바로가기 [Article Type] Article