Immunogenicity of candidate SARS-CoV-2 DNA vaccines based on the spike protein스파이크 단백질을 기반으로 한 후보 SARS-CoV-2 DNA 백신의 면역원성Article Published on 2022-08-012022-09-12 Journal: Virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Antigen candidate caused Cell-mediated immune responses control group coronavirus Coronavirus disease 2019 cytokine expression DNA DNA vaccine dose elevated evaluated full-length full-length S group highest humoral immune responses IgG immune response immunized immunogenicity mice NAb titer NAbs neutralizing antibody Prevent Protein public health S protein SARS-CoV-2 SARS-COV-2 infection significantly significantly increased spike Spike protein T-cell Response the spike protein vaccination vaccination schedule Vaccine [DOI] 10.1016/j.virol.2022.06.006 PMC 바로가기 [Article Type] Article
Durability of Heterologous and Homologous COVID-19 Vaccine Boosts이종 및 동종 COVID-19 백신의 내구성 향상Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenovirus age Analysis Antibody Response Antibody responses Asian assays binding black BNT162b2 BNT162b2 vaccine boost Boston CD4+ T-cell CD8+ Cellular immune response cellular immune responses cohort study COVID-19 COVID-19 vaccine cytokine Data analysis declined elicited evaluate evaluated female Follow-up functional antibody response Heterologous heterologous prime-boost Hispanic homologous humoral humoral immune responses immune response immune responses immunization immunogenicity individual intracellular cytokine staining involved IQR Latino Massachusetts median Messenger RNA mRNA mRNA vaccine Neutralizing neutralizing antibodies titer neutralizing antibody occurred of BNT162b2 omicron outcome participant peaked potential benefit potential benefits prime-boost regimen rapid increase regimen repeated response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants T-cell responses These data Vaccine was performed were assessed white [DOI] 10.1001/jamanetworkopen.2022.26335 PMC 바로가기 [Article Type] Article
CoVITEST: A Fast and Reliable Method to Monitor Anti-SARS-CoV-2 Specific T Cells From Whole BloodCoVITEST: 전혈에서 Anti-SARS-CoV-2 특정 T 세포를 모니터링하는 빠르고 신뢰할 수 있는 방법Article Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adjust antibodies Antibody detection automated Blood blood test can be used Cellular immune response cellular immunity cellular response comparable complex convalescent COVID-19 demonstrated determine diagnostic Donor ELISPOT Evidence explained gold gold standard healthy help house humoral immune response humoral immune responses IFN-γ IFN-γ ELISPOT immune protection immune responses Immune status IMPROVE individual less MONITOR pandemic Patient protocol Reinfection SARS-CoV-2 side simple Specific Support T cell T cells Test therapeutic approaches vulnerable patient vulnerable patients weakened immune system [DOI] 10.3389/fimmu.2022.848586 PMC 바로가기 [Article Type] Article
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort경증 회복기 코호트에서 SARS-CoV-2 유도 체액 및 세포 면역 반응과 관련하여 급성 감염 중 COVID-19 관련 증상의 유병률Article Published on 2022-07-012022-09-12 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute infection antibody antiviral immunity association Cellular immune response cellular immune responses Cohort convalescent convalescent individual correlation cough COVID-19 COVID-19 symptom COVID-19 symptoms disease severity effective eight evaluated humoral humoral immune response humoral immune responses IgG immune immune response intensities intensity Loss of Smell majority no difference polymerase chain positive Prevalence Prevent questionnaire recent reduced SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-specific T cell Serum level severe symptom severity shown Symptom symptom severity Symptoms T cell response T cells virus clearance were assessed [DOI] 10.1016/j.ijid.2022.04.019 PMC 바로가기 [Article Type] Article
Antibody Responses to SARS-CoV-2 in Children With COVID-19COVID-19에 걸린 어린이의 SARS-CoV-2에 대한 항체 반응Article Published on 2022-06-222022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed anti-S IgG anti-SARS-CoV-2 IgG Anti-spike antibody antibody level antibody levels Antibody Response Asymptomatic blood sample Blood samples caused children children with COVID-19 conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Cutoff detectable effective evaluate feature geometric mean geometric mean titer geometric mean titers GMT GMTs highest humoral immune response humoral immune responses IgG immune responses immune system Infection longitudinal study neutralizing antibody peaked positive positive rate positive rates reached remained respiratory response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus South Korea symptom onset symptomatic Vaccine development were measured with COVID-19 [DOI] 10.1093/jpids/piac012 PMC 바로가기 [Article Type] Article
Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 diseaseS1 소단위를 발현하는 뉴캐슬병 바이러스 벡터를 사용한 햄스터의 비강내 예방접종은 SARS-CoV-2 질병으로부터 동물을 보호합니다Article Published on 2022-06-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administer administration animals breath claimed coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Critical effective Efficacy elicited expressing hamster hamsters human clinical trial humoral immune responses immune responses long term lung damage mice Neutralizing antibodies newcastle disease virus pandemic phase prevented PROTECT Protective recent recorded recorded history reduced respiratory respiratory tract Safe SARS-CoV-2 SARS-CoV-2 disease severe acute respiratory syndrome Coronavirus short term significantly the disease the S1 subunit vaccination Vaccine vaccine candidate variant vectored vaccine Viral Viral load while [DOI] 10.1038/s41598-022-13560-z PMC 바로가기 [Article Type] Article
Seroprevalence of Anti-S1-RBD Antibodies in Pre-pandemic and Pandemic Subjects From Hail Region, KSA우박 지역, KSA의 전염병 전 및 전염병 대상체에서 항-S1-RBD 항체의 혈청유병률Article Published on 2022-06-092022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] age antibodies antibody level antibody levels Antigen asymptomatic individual Asymptomatic individuals Care clinical and demographic factors clinically collected complications Containment COVID-19 Demographic factors develop Efficacy effort ELISA exhibited exposure to female females group Hail house humoral immune responses identification immune responses in-house ELISA Infection male management neutralizing antibody new SARS-CoV-2 other coronavirus other coronaviruses pandemic positive Protein RBD antigen reduced Region required Research S-RBD S1-RBD Sample SARS-CoV-2 Screen Seroprevalence serum serum antibodies serum antibody serum IgG antibodies serum IgG antibody significantly significantly higher subject Surveillance the SARS-CoV-2 Vaccine variant variants [DOI] 10.3389/fpubh.2022.874741 PMC 바로가기 [Article Type] Article
Humoral response to mRNA vaccines against SARS-CoV-2 in patients with humoral immunodeficiency disease체액성 면역결핍증 환자에서 SARS-CoV-2에 대한 mRNA 백신에 대한 체액 반응Article Published on 2022-06-092022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95%CI Analysis anti-S anti-S antibody anti-SARS-CoV-2 antibody baseline BNT162b2 cross-sectional CVID dose evaluate evaluated healthy control healthy controls hospitalizations humoral humoral immune response humoral immune responses Humoral response Hypogammaglobulinemia IgG immune response immunodeficiency immunodeficiency disease immunoglobulin replacement therapy immunosuppressive drug immunosuppressive drugs individual induce Infection Mild moderate mRNA vaccine mRNA-1273 mRNA-based vaccine Patient patients patients with moderate Prevent proportion robust SARS-CoV-2 Spike protein subject the antibody response the spike protein vaccination vaccine dose vaccine doses were measured [DOI] 10.1371/journal.pone.0268780 PMC 바로가기 [Article Type] Article
Serological surveillance of healthcare workers to evaluate natural infection- and vaccine-derived immunity to SARS-CoV-2 during an outbreak in Dili, Timor-Leste동티모르 딜리에서 발생한 SARS-CoV-2에 대한 자연 감염 및 백신 유래 면역을 평가하기 위한 의료 종사자의 혈청학적 감시Article Published on 2022-06-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] (ChAdOx1 acquisition acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-N antibodies anti-N antibody Anti-spike antibodies baseline can be used ChAdOx1 characterisation conducted coronavirus Coverage COVID-19 DILI distribution effort evaluate HCW HCWs Health care Health care worker health care workers healthcare healthcare worker high uptake humoral immune response humoral immune responses IgG antibodies immune responses Immunity Infection infections International Local longitudinal study mitigate National natural infection outbreak participant Pathogens Protein respiratory Result SARS-CoV-2 serological serological surveillance seropositive severe acute respiratory syndrome Coronavirus Surveillance vaccination Vaccine [DOI] 10.1016/j.ijid.2022.03.043 PMC 바로가기 [Article Type] Article