Clonal Hematopoiesis of Indeterminate Potential Is Associated with Increased Age-Independent Morbidity and Mortality in Patients with COVID-19- the Beyond DNA COVID-19 Project
Conference abstract
[키워드] accounted
affected
age
age and sex
allele
approved
assays
association
ASXL1
ATAC-seq
baseline
Blood
blueprint
carried
ChIP
clinically
collected
common
Comorbidities
comparable
Coverage
COVID-19
COVID-19 diagnosis
COVID-19 disease severity
COVID-19 patient
CRP
CRS
cytokine
cytokine levels
Cytokine release syndrome
Cytokines
database
death
defined
described
Detection limit
DNA
download
elevated
ELISA assay
entire cohort
figure
Fisher
Follow-up
funding
Genes
grade 3
group
had more
hazard
healthy individual
Hematopoiesis
Hospitalization
hypoxemic
hypoxic respiratory failure
identify
IL6
Increased
increased mortality
indeterminate
indicated
individuals
Infection
Inflammation
Inflammatory
inflammatory cascade
Inflammatory marker
IRB
male
Mayo Clinic
MCP-1
median
median age
mononuclear cell
morbidity
Mortality
MPL
Mutation
mutations
neutropenia
no difference
observé
Older
pathophysiology
Patient
patients
patients with COVID-19
PBMC
Peripheral blood
Potential
proteomic study
reached
regression models
remained
Research
resolved
Respiratory failure
RNA
scale
Sequencing
severe disease
severity
Sex
SF3B1
Single Cell
ssDNA
subsequent
survival
survival analysis
TET2
the Kaplan-Meier method
the WHO
TNF-a
TP53
two groups
variables
variant
was performed
WHO
Wilcoxon rank sum
with COVID-19
[DOI] 10.1182/blood-2021-151548 [Article Type] Conference abstract
[DOI] 10.1182/blood-2021-151548 [Article Type] Conference abstract