Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients중환자 COVID-19 환자에서 좋지 않은 28일 결과와 관련된 기관지 폐포 및 혈액 면역 염증 바이오마커 식별Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission assays BAL BAL fluid BALF Biological biological profile biomarker signature Blood blood concentration bronchoalveolar Bronchoalveolar lavage Characteristics clinical Clinical outcome Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine defined described eicosanoid Eicosanoids elicited ELISA endothelial injury exhibited fiberoptic bronchoscopy Health Organization identification IFN-γ IL-10 IL-22 IL-5 IL-6 Infection Inflammatory response intensive care intensive care unit interferon Local metabolomic analysis neutrophil outcome Patient performed phenotype respiratory SARS-CoV-2 scale severe acute respiratory syndrome Coronavirus type I interferon Vascular Vasoactive VEGF WHO-CPS World Health Organization [DOI] 10.1038/s41598-022-13179-0 PMC 바로가기 [Article Type] Article
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vapingCOVID-19의 신경 전달 및 흡연 및 전자담배에 의한 신경염증 상태에서 성상교세포 안지오텐신 전환 효소 2의 잠재적 역할Article Published on 2022-06-072022-09-11 Journal: Fluids and Barriers of the CNS [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression affecting Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Astrocyte astrocytes Brain Cell cell type cells characterized Choroid plexus conducted COVID-19 COVID-19 patients COVID-19 severity cultured cells cytokine distribution domain endothelial cells entry receptor enzyme epithelial cell epithelial cells evaluate the effect exacerbate exacerbated expressed expression glial cell help highlight hypothalamus IL-5 IL-6 Immunocompromised immunohistochemistry immunomodulatory Inflammation manifestation marker Medulla oblongata meninges neural transmission Neurogenesis Neuron neurons Nicotine oblongata Pathogenesis pathogenesis of COVID-19 pericytes Post-infection Potential proinflammatory Real-time PCR responsible risk factor SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown significantly Smokers smoking stroma systemically third ventricle Transmission understanding ventricular were used western blot zone [DOI] 10.1186/s12987-022-00339-7 PMC 바로가기 [Article Type] Article
Increased proinflammatory cytokines in tears correspond with conjunctival SARS-CoV-2 positivity in symptomatic COVID-19 patients눈물의 증가된 전염증성 사이토카인은 증상이 있는 COVID-19 환자의 결막 SARS-CoV-2 양성과 일치합니다Article Published on 2022-05-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법, [키워드] Biomarker Biomarkers collected Concentration conjunctival conjunctival sac Conjunctival secretion Conjunctival secretions COVID-19 patient COVID-19 patients cytokine level Cytokines determined by GM-CSF greater IFN-γ IL-10 IL-12 IL-1B IL-2 IL-4 IL-5 IL-6 IL-8 Increased Infection Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators innate immune system magnetic bead ocular ophthalmic pathology Patient PCR testing positive Proinflammatory cytokine RNA RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity SARS-CoV-2 viral load selected significantly Swab Symptom symptomatic Tear tear film tears TNF-α Viral RNA [DOI] 10.1038/s41598-022-11285-7 PMC 바로가기 [Article Type] Article
Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19COVID-19의 기관 흡인물에서 BromAc의 생체 외 점액 용해 및 항염 활성Article Published on 2022-04-012022-09-12 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), MERS, SARS, 신약개발, 임상, 진단, 치료제, [키워드] Acetylcysteine anti-inflammatory activity anti-inflammatory effect BromAc caused chemokine collected Combination Concentration COVID-19 COVID-19 patient COVID-19 patients Critically ill CXCL8 Cytokine analysis Cytokine storm dose drug evaluated Ex vivo G-CSF IL-10 IL-13 IL-5 IL-6 IL-9 IP-10 lethal disease MCP-1 mechanical ventilation MIP-1b mucolysis mucolytic Mucolytic therapy NAC pandemic pharmacological treatment public health threat reducing reduction reduction in regulatory cytokine Respiratory disease robust SARS-CoV-2 sputum therapeutic options tracheal tracheal aspirate treat was performed [DOI] 10.1016/j.biopha.2022.112753 PMC 바로가기 [Article Type] Article
Effect of SARS-CoV-2 seropositivity on antigen – specific cytokine and chemokine responses in latent tuberculosisSARS-CoV-2 혈청 양성이 잠복 결핵에서 항원 특이적 사이토카인 및 케모카인 반응에 미치는 영향Comparative Study Published on 2022-02-012022-09-12 Journal: Cytokine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Antigen Antigen specific responses baseline chemokine chemokines Control CXCL1 CXCL10 CXCL9 cytokine cytokine response Cytokines demonstrated Effect examined globe groups healthy control IFNγ IL-10 IL-12 IL-17 IL-1β IL-2 IL-4 IL-5 IL-6 immune response individual individuals Infection influence investigated LTBI mycobacterial Mycobacterium tuberculosis response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 seropositivity. significant difference stimulated TNFα Tuberculosis [DOI] 10.1016/j.cyto.2021.155785 PMC 바로가기 [Article Type] Comparative Study
Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID-19 patients피부 및 전신 고인 염증은 심하게 아픈 Covid-19 환자에서 황반 약물 엑스 산마를 유도합니다.Article Published on 2022-02-012022-08-31 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed CCL11 CD8 cellular chemokine chemokines Cluster Clustering coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patient COVID-19 patients Cutaneous cytokine Cytokine storm Cytometry demonstrated Diagnosis drug rash drug-induced maculopapular exanthema. eosinophil eosinophilia Exanthema Features healthy controls hypersensitivity hypersensitivity reaction hypersensitivity reactions IFN-γ IL-4 IL-5 IL-6 inflammatory mediator Inflammatory mediators Macrophage MCP-3 MDR mediators nasopharyngeal Patient PCR performed positive promote proteomic rashe respiratory RNA sequencing robust SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe COVID-19 patients skin biopsies skin biopsy systemic cytokine systemic hyperinflammation systemic symptom systemic symptoms T cell T cells TNF Transcriptome turn upregulation [DOI] 10.1111/all.14983 PMC 바로가기 [Article Type] Article
The use of biologics in personalized asthma careArticle Published on 2022-01-202024-09-04 Journal: Expert review of clinical immunology [Category] 대상포진, [키워드] antibodies Asthma biologics eosinophilic asthma IL-5 Interleukins [DOI] 10.1080/1744666X.2021.2006635 PMC 바로가기 [Article Type] Article
Body composition, physical capacity, and immuno-metabolic profile in community-acquired pneumonia caused by COVID-19, influenza, and bacteria: a prospective cohort studyArticle Published on 2022-01-052022-10-04 Journal: International journal of obesity (2005) [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 95% CI acute respiratory syndrome Admission Analysis Bacteria Bacterial Body body composition body mass C-reactive protein caused characterized community-acquired pneumonia coronavirus coronavirus disease COVID-19 cytokine diabetes etiology fat-free mass Glucose groups handgrip strength hemoglobin hyperglycemia IFN-γ IL-10 IL-12p70 IL-18 IL-1β IL-5 IL-6 IL-8 Inflammation Inflammatory response Influenza interferon lipids low handgrip strength mean difference no difference not affect obesity pathogen Patient patients hospitalized patients with COVID-19 patients with influenza physical activity levels physical capacity Pre-diabetes prospective cohort study Prospective Study questionnaire respiratory virus Result SARS-CoV-2 the patient tumor necrosis factor-α Waist circumference were assessed were measured [DOI] 10.1038/s41366-021-01057-0 PMC 바로가기 [Article Type] Article
Pilot Study on the Impact of a Home-Based Exercise Program on Inflammatory Cytokines and Quality of Life in Men with Prostate Cancer Under Active SurveillanceArticle Published on 2022-01-012022-11-15 Journal: Cancer control : journal of the Moffitt Cancer Cen [Category] 바이오마커, [키워드] 6-minute walk test 6MWT 6MWT distance Active surveillance aerobic Alpha baseline Biomarker Biomarkers body mass index collected control group COVID-19 decrease emotional endothelial exercise Exercise intervention functional Future growth factor IL-12 IL-1α IL-5 IL-6 Impact increase in INF-γ Inflammatory biomarker Inflammatory cytokine interferon-γ interleukin-6 Intervention intervention group Isolation life marker men Necrosis parallel group physical Program Prostate Prostate cancer Quality Quality of life Randomized Significant significantly increased TNF-α translation tumor progression Vascular VEGF was used [DOI] 10.1177/10732748221130964 PMC 바로가기
COVID-19 in a Patient With Severe Eosinophilic Asthma on Benralizumab Therapy: A Case Report and Review of LiteratureAllergy/Immunology Published on 2021-12-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect antiviral activity Asthma Asymptomatic COVID-19 benralizumab clinical status contribute coronavirus coronavirus disease Course COVID-19 COVID-19 patients COVID-19 prognosis cytotoxicity deplete Deterioration develop eosinophil Eosinophilic functions IL-5 immunoregulation Infection inflammatory reaction literature literature review modulation monoclonal antibody Patient positive report review SARS-CoV-2 Severe asthma severity of COVID-19 tested the disease therapy [DOI] 10.7759/cureus.20644 PMC 바로가기 [Article Type] Allergy/Immunology