Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할Review Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료법, [키워드] Balanced Blood circulation COVID-19 cytokine Cytokine storm Cytokine storms Cytokines death driving dsRNA Elimination endosomal Factor help IL-1β IL-4 IL-6 IL-8 Imbalance immune regulation individual Inflammatory inflammatory signaling innate immune system interferon interleukin killing MAPK membrane-bound modulation multiple organ failure multiple organ failures multiple-organ multiple-organ failure Necrosis NF-κB nonself other organs pathogen Pro-inflammatory genes pro-inflammatory mediator pro-inflammatory mediators recognize recognizing replicate role SARS-CoV-2 Signaling ssRNA ssRNA. systemic circulation the cytokine storm TLR TLR3 TLR4 TLR7 TLR7/8 TLR8 TLRs Toll-like receptor Toll-like receptors Transcription translation TRIF Tumor tumor necrosis tumor necrosis factor [DOI] 10.1002/jmv.27405 PMC 바로가기 [Article Type] Review
Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection가용성 면역 체크포인트는 COVID-19 및 HIV 감염이 있는 과음 알코올 사용자의 조절이 잘 안 됩니다.Review Published on 2022-02-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] alcohol alcohol consumption alcohol-associated liver disease (ALD) antibacterial immunity antibodies Antiretroviral therapy ART balance binding biological function Biological functions biological significance Biomarker Biomarkers blockade blocking antibodies bloodstream Cancer circulating competition COVID-19 COVID-19 patient COVID-19 patients disease Diseases dysregulated dysregulation Effect Efficacy elevated Evidence exacerbate focus form Health healthy heavy alcohol user HIV HIV infection ICP Imbalance immune Immune cell immune cells immune checkpoint immune defense immune microenvironment immune regulation immune responses in vitro in vivo Infectious diseases Inflammation inhibitory Interaction malignant cell malignant cells membrane membrane-bound mRNA occur Pandemics pathophysiological condition pathophysiological conditions peripheral circulation plasma Plasma levels PLHIV protease public health reducing regulate Regulation Regulatory secretion self-tolerance severity of COVID-19 significantly soluble immune checkpoint stimulatory storm Surveillance Therapies Tumor user with HIV [DOI] 10.3389/fimmu.2022.833310 PMC 바로가기 [Article Type] Review
Comparative Analysis of Circulating Levels of SARS-CoV-2 Antibodies and Inflammatory Mediators in Healthcare Workers and COVID-19 Patients의료 종사자 및 COVID-19 환자의 SARS-CoV-2 항체 및 염증 매개체 순환 수준의 비교 분석Article Published on 2022-02-232022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] advance anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies Antiviral Asymptomatic Brazil CCL2 CCL2/MCP-1 chemokines clinical evolution Comparative contribute COVID-19 COVID-19 patient Cytokines cytokines/chemokines dead died evaluate explain Factor form group groups HCW healthcare healthcare worker Healthcare workers Host IFN-γ IgA IgG IL-10 IL-6 Imbalance individual individuals Inflammatory mediators Inflammatory response knowledge Level MCP-1 mediator mediators Mild pathology pathophysiology patients patients with COVID-19 pro-inflammatory mediator pro-inflammatory mediators recovered patient SARS-CoV-2 sick specific antibodies specific antibody symptomatic the disease TNF-α worker [DOI] 10.3390/v14030455 PMC 바로가기 [Article Type] Article
Obstetric outcomes in pregnant COVID-19 women: the imbalance of von Willebrand factor and ADAMTS13 axis임신 한 Covid-19 여성의 산과 적 결과 : Von Willebrand Factor and Adamts13 축의 불균형Observational Study Published on 2022-02-212022-09-10 Journal: BMC Pregnancy and Childbirth [Category] COVID19(2023년), Fulltext, MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] 95%CI AB0 blood group system ADA ADAMTS13 Admission adverse outcomes age association Asymptomatic Biomarker clinical information clinical outcomes collected confounders COVID-19 COVID-19 patient COVID-19 patients damage Decision making decision making process demographic diagnosis of SARS-CoV-2 discharge evaluate Follow-up gestational age hospital Hospital admission Imbalance independent Infection investigated Italy laboratory data laboratory parameter Laboratory parameters laboratory-confirmed Logistic regression Logistic regression analysis marker mechanism median microangiopathy monitoring outcome Pregnancy pregnant pregnant women preterm delivery regression analysis responsible Result risk SARS-COV-2 infection significantly significantly higher significantly lower Support Symptom symptom of infection thrombotic microangiopathy von Willebrand factor was performed with COVID-19 [DOI] 10.1186/s12884-022-04405-8 PMC 바로가기 [Article Type] Observational Study
Molecular and Cellular Mechanisms of M. tuberculosis and SARS-CoV-2 Infections—Unexpected Similarities of Pathogenesis and What to Expect from Co-InfectionM. tuberculosis와 SARS-CoV-2 감염의 분자 및 세포 기전 - 병인의 예상치 못한 유사성과 동시 감염에서 기대할 수 있는 것Review Published on 2022-02-172022-09-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] M. tuberculosis infection caused CD4+ T cell cellular Coronavirus infection COVID-19 Critical Diagnosis Disease progression Features Federation hyperinflammation Imbalance Immune suppression immunological Infection Inflammation Isolation knowledge lung tissue injury lymphopenia molecular New coronavirus pathology Personal protective equipment pulmonary tuberculosis Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 virus similarities similarity subset T cell Th cell subsets the SARS-CoV-2 virus tissue Treatment Tuberculosis with COVID-19 [DOI] 10.3390/ijms23042235 PMC 바로가기 [Article Type] Review
Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients입원하지 않은 환자의 코로나19 경구 치료용 몰누피라비르Clinical Trial Published on 2022-02-102022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, 치료제, [키워드] 95% CI 95% confidence interval active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adverse adverse event adverse events All participants Analysis Antiviral assigned baseline baseline characteristics conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 illness death demonstrated diabetes died double-blind early treatment Efficacy and safety efficacy end point end point Enrollment evaluate event Evidence evidence of Hospitalization Hospitalized Imbalance in some incidence interim analysis laboratory-confirmed Mild-to-moderate molnupiravir New oral participant Patient Phase 3 Placebo placebo group placebo-controlled trial progression randomization Randomized Randomly receive reduce reduced reported Result risk risk factor SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 illness Sex Sharp Subgroup analyses subgroups Symptom the placebo group Treatment Trial two groups Viral load was performed [DOI] 10.1056/NEJMoa2116044 PMC 바로가기 [Article Type] Clinical Trial
Innate and Adaptive Immunity Imbalance With Severe COVID-19 Pneumonia in Children and AdultsPediatrics Published on 2021-12-152022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Abnormalities adaptive adaptive immune cells Admission Adult patient Adult patients Adults alteration analyzed CD14+ monocyte CD3+ CD4+ T cell CD8+ T cell Characteristics Chest CT children clinical complication clinical manifestation Clinical symptoms Comorbidities Control controls coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical enrolled Frequency had more healthy Imbalance immune Immune cell immune response alteration Inflammatory response Innate Innate immune cells Laboratory laboratory abnormalities Laboratory features lymphocyte Mild much higher Patient patients pilot study Pneumonia Prevalence radiological real-time RT-PCR recruited SARS-CoV-2 severe patients significantly lower subpopulations subset survived T-lymphocyte with COVID-19 [DOI] 10.3389/fped.2021.736013 PMC 바로가기 [Article Type] Pediatrics
scCODA is a Bayesian model for compositional single-cell data analysisArticle Published on 2021-11-252022-10-04 Journal: Nature Communications [Category] 진단, [키워드] analyses Bayesian biological processes Cell cell type change changes in complex Data analysis demonstrated disease Diseases driver Effect experiment hallmark Imbalance sample sizes scRNA-seq data scRNAseq single-cell Statistical methods Still transcriptomics [DOI] 10.1038/s41467-021-27150-6 PMC 바로가기 [Article Type] Article
Ultrasensitive Detection of COVID-19 Causative Virus (SARS-CoV-2) Spike Protein Using Laser Induced Graphene Field-Effect Transistor레이저 유도 그래핀 전계 효과 트랜지스터를 사용한 COVID-19 원인 바이러스(SARS-CoV-2) 스파이크 단백질의 초고감도 검출Article Published on 2021-11-172022-09-10 Journal: Molecules [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition binding biosensor can not Causative caused channel Concentration conditions contagious coronavirus COVID-19 current detect detection drug early diagnosis field-effect transistor flexible flexible devices Graphene human infectious disease human serum Imbalance induced Infectious disease Isolation labeling Laboratory Laser LIG-FET nucleic acid outbreak PBS phosphate phosphate-buffered saline platform porous Protein reduction respiratory SARS-CoV-2 SARS-CoV-2 spike protein sensor severe acute respiratory syndrome Coronavirus specific antibodies specific antibody specificity spike Spike protein supply supply and demand the SARS-CoV-2 the spike protein transistor Vaccines virus [DOI] 10.3390/molecules26226947 PMC 바로가기 [Article Type] Article
Microbiome Profiling Using Shotgun Metagenomic Sequencing Identified Unique Microorganisms in COVID-19 Patients With Altered Gut MicrobiotaMicrobiology Published on 2021-10-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Affect alteration Altered Bacteroide Bacteroidete Bifidobacterium longum Classifier Clostridium COVID-19 COVID-19 patients diagnostic disease severity distress eight Enterobacter Erysipelotrichaceae Eubacterium examined Firmicute Fusobacterium gastrointestinal symptoms gut microbiota healthy control Identified Imbalance Infection KEGG management marker metagenomic sequencing microbial Microbiome microorganism Patient patients with COVID-19 Prevotella Profiling progression provide random respiratory virus SARS-CoV-2 shotgun Spearman’s correlation Streptococcus Streptococcus salivarius subset Symptoms syndrome therapy understanding unique [DOI] 10.3389/fmicb.2021.712081 PMC 바로가기 [Article Type] Microbiology