Role of the PD-1 and PD-L1 axis in COVID-19COVID-19에서 PD-1 및 PD-L1 축의 역할Editorial Published on 2022-09-012022-09-11 Journal: Future Microbiology [Category] 바이오마커, [키워드] Abstract adaptive adaptive immune cells COVID-19 COVID-19 patient dysregulated expression immune immune cells immune checkpoint molecules Innate immune cells innate immune cells. Ligand PD-1 PD-L1 Prognostic marker Prognostic markers role SARS-CoV-2 Severe case severe cases therapeutic target therapeutic targets [DOI] 10.2217/fmb-2022-0103 PMC 바로가기 [Article Type] Editorial
Cleavage-Responsive Biofactory T Cells Suppress Infectious Diseases-Associated HypercytokinemiaArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] 바이오마커, [키워드] activate administration Alpha Blood chimeric cleavage cleavage site coronavirus disease COVID-19 digestion Diseases domain drug endothelial engineered blood vessel engineered T cell enzyme EPCR Express expressing hypercytokinemia immune cells in vivo induce Infectious disease Infectious disease. lentiviral system lung tissue multiple organ failure Necrosis overcome peptide Prevent Protein receptor Release Sepsis suppress T cell therapeutic thrombin receptor TRAP Treatment Vascular damage vessel [DOI] 10.1002/advs.202201883 PMC 바로가기
Immune response in ofatumumab treated multiple sclerosis patients after SARS-CoV-2 vaccinationArticle Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] alteration anti-CD20 anti-CD20 therapy antibody applied approach B cell caused CD4 Cellular immune response cellular immunity characterized Complete decrease Delta disorder dosage Effect elicit Frequency healthy controls humoral humoral immune response immune Immune cell immune cells immune response Immunosuppression implication information investigated mean treatment duration Multiple multiple sclerosis neutralization capacity Ofatumumab ofatumumab. omicron pandemic Patient preserved Regulatory T cell SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 variant sclerosis subcutaneously subpopulation sustained T cell T cell response T helper Th1 titer treated treated patient Treatment Tregs vaccination was impaired wild type [DOI] 10.3389/fimmu.2022.980526 PMC 바로가기
Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19Research article Published on 2022-08-242022-10-05 Journal: EBioMedicine [Category] SARS, 진단, 치료기술, [키워드] alveolar damage analysis Autopsy Bacteria Candida parapsilosis CD8+ T cells CD8+T cells Cell changes in complex correlated COVID-19 COVID-19 case COVID-19 patients DAD diffuse Diffuse alveolar damage disease eight elevated enriched pathway exhibit Extracellular matrix Factor fatal COVID-19 feature fibroblasts finding foundation funding fungi heart heterogeneity histological humoral immune immune cells immunohistochemistry immunological immunopathology implication innate immune response Lung disease lung tissue Lungs Macrophage macrophages management Melinda Gate modulate molecular multiplex occur Patient performed progression quantified Regeneron Pharmaceuticals response SARS-CoV-2 Secondary infection subsequent Support Swedish the disease Transcriptome Treatment strategies [DOI] 10.1016/j.ebiom.2022.104229 [Article Type] Research article
Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is keyArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] age cellular cellular heterogeneity Clinical outcome clinical outcomes Comorbidities complex correlation COVID-19 COVID-19 disease COVID-19 disease severity disease severity dysregulation functional Gender genetics granular heterogeneity heterogeneous heterogeneous population highlight Host host response identify immune immune cells Immune profile immune response immunological mechanism impairment Infectious disease information pandemic Patient progression regulated RNA-Seq severity single-cell genomics single-cell genomics. subset the disease with COVID-19 [DOI] 10.3389/fimmu.2022.973070 PMC 바로가기
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patientsSARS-CoV-2는 시험관 내 및 COVID-19 환자에서 1차 인간 면역계 세포를 생산적으로 감염시킵니다Article Published on 2022-08-172022-09-11 Journal: Journal of Molecular Cell Biology [Category] SARS, 진단, 치료기술, 치료법, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Apoptosis appear B and T lymphocytes B cells B lymphocyte B lymphocytes CD4+ T lymphocyte Cell circulating leukocytes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm disease pathogenesis disease severity double-stranded RNA expressive flow cytometry hallmark Host Human immune system hyperinflammatory state Immune cell immune cells immune dysfunction immunofluorescence analysis implication in vitro indicated infect Infection inflammatory state leukocyte leukocytes lung tissue Lymphocytes lymphocytopenia monocyte Monocytes mononuclear cell mononuclear cells outcome patients PBMC Peripheral blood peripheral blood mononuclear cell (PBMC). Peripheral blood mononuclear cells Prognosis progression Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro severe acute respiratory syndrome Coronavirus susceptible sustained symptom onset T cell T lymphocytes Viral viral replication Viral RNA virus spread [DOI] 10.1093/jmcb/mjac021 PMC 바로가기 [Article Type] Article
Tuning immunity through tissue mechanotransduction Reviews Published on 2022-08-162022-10-05 Journal: Nature reviews. Immunology [Category] 유전자 메커니즘, [키워드] adaptive immune system addition Alter arising biochemical Cell cell activation cellular change changes in conditions cytokine production disease Extracellular matrix function Immune cell immune cells immune regulation immune response Immunity Infection Inflammatory response inflammatory state Injury metabolism multiple pathway pathway proliferation regulate response tissue tissue microenvironment tuning [DOI] 10.1038/s41577-022-00761-w [Article Type] Reviews
A Comparative Study of the Plasma Chemokine Profile in COVID-19 Patients Infected with Different SARS-CoV-2 Variants다양한 SARS-CoV-2 변이체에 감염된 COVID-19 환자의 혈장 케모카인 프로필 비교 연구Comparative Study Published on 2022-08-132022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, [키워드] Activation acute respiratory distress acute respiratory distress syndrome Affect blood plasma cause caused CCL11 CCL2 CCL2/MCP-1 CCL22 CCL3 CCL4 CCL7 cellular and molecular Cellular and molecular mechanisms chemoattraction chemokine chemokines Clinical course common cold Comparative Concentration concentrations COVID-19 CX3CL1 CXCL1 CXCL10 CXCL10/IP-10 CXCL8 CXCL9 Delta disease severity drop Eotaxin Genetic variant IL-8 Immune cell immune cells immune responses in viral Inflammation involved Lower respiratory tract Macrophage macrophage-derived chemokine. manifestation MCP-1 MCP-3 mechanism Mutation omicron Patient Pneumonia profile proliferation Protein respiratory distress SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants significantly statistically significant Symptom syndrome upper and lower respiratory tracts variant variants variants of SARS-CoV-2 Viral proteins viral variant virion virus Wuhan strain [DOI] 10.3390/ijms23169058 PMC 바로가기 [Article Type] Comparative Study
T cell perturbations persist for at least 6 months following hospitalization for COVID-19T 세포 교란은 COVID-19로 입원한 후 최소 6개월 동안 지속됩니다.Article Published on 2022-08-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료법, [키워드] addition affected alteration anti-Nucleocapsid IgG antibody Arm CD4 CD57 CD69 CD8 Cell consequence convalescence COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients dependent on elevated event expressing flow cytometry follicular Hospitalization Humoral response humoral responses IgG immune immune cells immune system Immunity Inclusion marker Neutralizing Neutralizing antibodies neutralizing antibody responses Pathogenesis Perturbation Population populations SARS-CoV-2 spectral flow cytometry. study duration sustained symptom onset T cell T cell activation T cell impairment T cell responses T cell subsets T cells T helper TEMRA the disease upregulated with COVID-19 [DOI] 10.3389/fimmu.2022.931039 PMC 바로가기 [Article Type] Article
Cell surface SARS-CoV-2 nucleocapsid protein modulates innate and adaptive immunity세포 표면 SARS-CoV-2 뉴클레오캡시드 단백질은 선천성 및 후천성 면역을 조절합니다Article Published on 2022-08-052022-09-11 Journal: Science Advances [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] activate adaptive antibody antigenicity bind Cell cell surface cells chemokine chemokines chemotaxis Combination conserved CoVs cross-reactive cytosol detect electrostatic heparan sulfate heparin high affinity high-affinity binding human CoVs immune cells Immunity induce infected cells inhibited Innate immune cells Innate immunity leukocyte leukocytes live cells MERS-CoV modulate neighboring cell neighboring cells nucleocapsid protein Protein released SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequestering Strains sulfate sulfated T cell T cell responses transfected cell Vaccine zoonotic [DOI] 10.1126/sciadv.abp9770 PMC 바로가기 [Article Type] Article