Case Report: Clinical Management of a Patient With Metastatic Non-Small Cell Lung Cancer Newly Receiving Immune Checkpoint Inhibition During Symptomatic COVID-19증례 보고: 코로나19 증상이 있는 동안 면역 체크포인트 억제를 새로 받은 전이성 비소세포폐암 환자의 임상 관리Case Reports Published on 2021-12-202022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] activated ambulatory patient Analysis anti-cancer treatment anti-PD1 antiviral immunity blockade CD4 CD8 cellular change clinical Corticosteroid Course COVID-19 CT scan Effect feasible Follow-up healthy High-dose Hospitalized humoral immune response IgG immune checkpoint Immunotherapy inhibition initiated lesion lung cancer male malignancy management metastatic Neutralizing NSCLC Patient PD1 Pembrolizumab Pneumonia Pneumonitis presenting Radiographic SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection serum sustained symptomatic T cell Tfh the patient treatment initiation worsened [DOI] 10.3389/fimmu.2021.798276 PMC 바로가기 [Article Type] Case Reports
Microbiome Crosstalk in Immunotherapy and Antiangiogenesis TherapyReview Published on 2021-10-212023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Angiogenesis Chinese medicine immune checkpoint Immunotherapy Microbiome prebiotics [DOI] 10.3389/fimmu.2021.747914 PMC 바로가기 [Article Type] Review
Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer PatientsOriginal Research Published on 2021-03-082023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] B cell immune checkpoint immune microenvironment lung cancer Regulatory T cell Tertiary lymphoid structure [DOI] 10.3389/fimmu.2021.626776 PMC 바로가기 [Article Type] Original Research
VISTA: A Target to Manage the Innate Cytokine StormVISTA: 타고난 사이토카인 폭풍을 관리하기 위한 표적Review Published on 2021-02-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] agonistic antibodies Anti-inflammatory Antigen presentation Autoimmune diseases blockade Cancer canonical marker canonical markers CD14 CD16 Cell change Complete conserved COVID-19 cytokine Cytokine storm Cytokine storms Diseases driven by dysregulated immune response expression Fcγr3a focus highlight human monocyte human monocytes Hyperinflammatory response IFN-I immune immune checkpoint immune responses immune system Immunity Immunosuppression Immunotherapy implication Inflammatory responses inhibitory Innate monocyte reprogramming Monocytes myeloid myeloid cell myeloid cells offer pathogenic pathology pathway Pathways phenotype receptor related diseases storm Support suppress T cell T cell activation target the interferon therapeutic triggering unique Viral viral infection viral infections vista while [DOI] 10.3389/fimmu.2020.595950 PMC 바로가기 [Article Type] Review
Efficacy of a Cap-Dependent Endonuclease Inhibitor and Neuraminidase Inhibitors against H7N9 Highly Pathogenic Avian Influenza Virus Causing Severe Viral Pneumonia in Cynomolgus MacaquesArticle Published on 2020-11-302023-05-31 Journal: Antimicrobial Agents and Chemotherapy [Category] 조류인플루엔자, [키워드] cap-dependent endonuclease inhibitor H7N9 avian influenza virus Highly pathogenic avian influenza virus immune checkpoint neuraminidase inhibitor nonhuman primate [DOI] 10.1128/AAC.01825-20 PMC 바로가기
A Granulocytic Signature Identifies COVID-19 and Its Severity과립구 시그니처는 COVID-19 및 그 심각성을 식별합니다Observational Study Published on 2020-11-132022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, 임상, [키워드] (neutrophil accompanied Admission Alter Analysis approach association basophil basophils Biomarker CD11b CD16 circulating conducted COVID-19 COVID-19 patient COVID-19 patients CRTH2 disease downregulation dysregulation eosinophil eosinophils expression Frequency functional phenotype granulocyte Granulocytes Granulocytic healthy control healthy controls hospital ward identify immune immune checkpoint immune dysregulation immune marker immune markers immunoparalysis Immunophenotyping Increased individual integrin intensive care intensive care unit admission leukocyte leukocytes lymphocyte marker Mild monocyte neutrophil Neutrophils pathophysiological Patient PD-L1 Phenotypic marker Phenotypic markers predict SARS-CoV-2 severe disease severity signature stages subset supported uninfected was performed [DOI] 10.1093/infdis/jiaa591 PMC 바로가기 [Article Type] Observational Study
Immune Checkpoints in Viral InfectionsReview Published on 2020-09-212022-10-28 Journal: Viruses [Category] COVID-19, [키워드] antiviral therapy applied Cancer cells cancer treatment chronic infection COVID-19 Evidence immune immune checkpoint Immune checkpoint blockade immune system Immunotherapy in viral increasingly infections mechanism mounted recent finding regulate suggested T-cell therapy viral infection viral infections virus virus-infected cells [DOI] 10.3390/v12091051 PMC 바로가기 [Article Type] Review
Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses하이드록시클로로퀸과 아지스로마이신의 병용 치료는 항암 면역 반응의 치료 유도와 양립 가능합니다.Article Published on 2020-07-082022-09-11 Journal: Oncoimmunology [Category] SARS, 바이오마커, 비임상, 신약개발, 임상, [키워드] administration Affect antibiotic anticancer antimalarial antimalarial drug appear autophagic flux AZI Azithromycin blockade body weight breath Campus Cancer Cancer patients cancers cisplatin clinical trial Combination combination therapy COVID-19 crizotinib curative dose doses Gustave Roussy HCQ Hydroxychloroquine immune immune checkpoint immune response immune responses immunogenic cell death Immunotherapy indicated inducer interfere investigated lung cancer mice not affect oxaliplatin PD-1 preclinical study reduction in regimen SARS-CoV-2 therapeutic treated Treatment Tumor tumor growth utility [DOI] 10.1080/2162402X.2020.1789284 PMC 바로가기 [Article Type] Article
Upregulation of CD47 Is a Host Checkpoint Response to Pathogen RecognitionResearch Article Published on 2020-06-232023-07-02 Journal: mBio [Category] SARS, [키워드] CD47 host response immune checkpoint Innate immunity pathogen recognition receptors [DOI] 10.1128/mBio.01293-20 PMC 바로가기 [Article Type] Research Article
Regulation of Tumor Immunity by Lysophosphatidic AcidReview Published on 2020-05-102023-08-30 Journal: Cancers [Category] E형 간염, [키워드] Autotaxin Cytotoxic T cells immune cells immune checkpoint Immunoediting Immunosuppression immunosurveillance LPA LPAR5 lysophosphatidic acid tumor microenvironment tumor-associated macrophages [DOI] 10.3390/cancers12051202 PMC 바로가기 [Article Type] Review