(+)-Usnic acid and its salts, inhibitors of SARS-CoV-2, identified by using in silico methods and in vitro assay(+)-Usnic acid 및 그 염, SARS-CoV-2 억제제, in silico 방법 및 시험관 내 분석을 사용하여 확인Article Published on 2022-07-302022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] anti-SARS-CoV-2 Antiviral Beta variant beta variants calculated caused compounds continuum COVID-19 COVID-19 treatment database Efficacy immunofluorescence In silico method in vitro in vivo inhibitors inhibitors of SARS-CoV-2 investigated molecular molecular dynamics monoclonal antibodies Mpro protein pandemic positive control Protein target protein-ligand interaction Remdesivir required RMSD SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 variants selectivity index severe acute respiratory coronavirus Severe acute respiratory coronavirus-2 sodium surface area targets Treatment treatment for COVID-19 usnic acid Virtual screening was performed was selected [DOI] 10.1038/s41598-022-17506-3 PMC 바로가기 [Article Type] Article
Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood whole blood. [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article
Platelet activation and partial desensitization are associated with viral xenophagy in patients with severe COVID-19혈소판 활성화 및 부분 탈감작은 중증 COVID-19 환자의 바이러스 이종과 관련이 있습니다Article Published on 2022-07-122022-09-11 Journal: Blood advances [Category] COVID19(2023년), SARS, 치료법, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Alter assays autophagy Bacterial sepsis changes in Combination Complication coronavirus Critically ill critically ill patients Cytokines decrease develop exhibited flow cytometry fraction Gene Expression GPVI healthy healthy donor healthy donors immunofluorescence indicated infected patient infected patients intensive care intensive care unit interactions intracellular vesicle investigated labeling leukocyte Localization lung marker mass spectrometry Microscopy Nucleocapsid proteins parameter Patient patients with COVID-19 plasma Platelet platelet activation platelet aggregation platelet-rich thrombi Platelets Proinflammatory cytokine proinflammatory cytokines prospective cohort Protein reduction SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles secretion selective Sepsis severe acute respiratory syndrome Coronavirus severe COVID-19 shown spike Stimulation Structure Tandem mass spectrometry These data thrombi thrombocytopenia transmission electron microscopy Xenophagy [DOI] 10.1182/bloodadvances.2022007143 PMC 바로가기 [Article Type] Article
Viral culture and immunofluorescence for the detection of SARS-CoV-2 infectivity in RT-PCR positive respiratory samplesRT-PCR 양성 호흡기 샘플에서 SARS-CoV-2 감염성 검출을 위한 바이러스 배양 및 면역형광Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] cells correlation COVID-19 Ct value Culture gold gold standard Immunocompromised Immunocompromised patient Immunocompromised patients immunofluorescence indicate individuals Infection prevention infective Infectivity inoculated Isolation median Other respiratory viruses Patient positive positive correlation positive individuals Prevention and control Probability protocol reference method respiratory sample respiratory viruses RT-PCR RT-PCR Ct SARS-CoV-2 SARS-CoV-2-positive individual severe COVID-19 subject Symptom symptom onset Vero E6 VERO E6 cells viral culture Viral isolation. virus [DOI] 10.1016/j.jcv.2022.105167 PMC 바로가기 [Article Type] Article
Fcγ-Receptor-Based Enzyme-Linked Immunosorbent Assays for Sensitive, Specific, and Persistent Detection of Anti-SARS-CoV-2 Nucleocapsid Protein IgG Antibodies in Human Sera인간 혈청에서 항-SARS-CoV-2 뉴클레오캡시드 단백질 IgG 항체의 민감하고, 특이적이고, 지속적인 검출을 위한 Fcγ-수용체 기반 효소 연결 면역흡착 분석법Article Published on 2022-06-152022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African analytical sensitivity anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibody antibody waning Antigen antigen-antibody complexes Asia binding complexes Concentration convalescence convalescent phase coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-reactivity detection diagnostic diagnostic sensitivities dilutions ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epidemiological studies Epidemiological study Europe FcγR Human IgG IgG antibody Immune complexes immunoassay immunofluorescence immunoglobulins immunological indirect immunofluorescence Infection Infectious disease Laboratory laboratory methods and tools longitudinal samples mandatory morbidity morbidity and mortality mortality rates nucleocapsid protein Pathogens persistent platform Population Postinfection Prevalence prozone receptor Region respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibody sensitive sensitivity serological test Serological tests serum serum sample serum samples severe acute respiratory syndrome Coronavirus significantly significantly higher solution South America Specific Specificities specificity titer Vaccine validation Viral Viral diseases viral diseases. was performed while [DOI] 10.1128/jcm.00075-22 PMC 바로가기 [Article Type] Article
Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study헤파라나제는 COVID-19에서 내피 글리코칼릭스 손상의 추정 매개체입니다 - 개념 증명 연구Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] atomic Bacterial sepsis changes in Coronavirus disease 2019 correlated COVID-19 COVID-19 patient cultured cell damage dimension disease endothelial endothelial glycocalyx (EG) enzyme excess experiments glycocalyx Heparanase heparanase (HPSE) heparin HPSE immunofluorescence inhibition Injury marker mediator Microscopy plasma plasma sample prevented Protective protective effect serum shown translational Vascular endothelium vessel videomicroscopy. [DOI] 10.3389/fimmu.2022.916512 PMC 바로가기 [Article Type] Article
Nucleocapsid Specific Diagnostics for the Detection of Divergent SARS-CoV-2 Variants다양한 SARS-CoV-2 변이체의 검출을 위한 뉴클레오캡시드 특이적 진단Article Published on 2022-06-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] assays conserved COVID-19 pandemic CR3022 described detect detection diagnostics immune immunoassays immunofluorescence immunoplaque assay mutability Mutation N-terminal domain nanobody nucleocapsid nucleocapsid. Omicron variant Omicron variants Receptor binding S309 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Specific specific antibodies spike glycoprotein spike-specific antibodies Spike-specific antibody targets Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2022.926262 PMC 바로가기 [Article Type] Article
Immunofluorescence-Mediated Detection of Respiratory Virus Infections in Human Airway Epithelial CulturesArticle Published on 2022-06-012022-11-15 Journal: Current protocols [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome Air-liquid interface airway airway epithelial cell airway epithelium Analysis antibody basic Cell Cell culture cell tropism cellular coronavirus Culture current death detection determine double-stranded RNA Effect Efficiency epithelial Factor feature Generation Host Human human airway epithelial immortalized cell line immunofluorescence immunofluorescence microscopy in vivo include infect infected cell infected individual Infection Influenza virus LLC Microscopy Mild mucosal epithelium pathogen Periodical phenotype protocol respiratory respiratory tract respiratory virus Respiratory virus. rhinovirus Spread Symptom target upper respiratory tract viral pathogen virus [DOI] 10.1002/cpz1.453 PMC 바로가기
Evolution of pathological findings in surveillance biopsies of lung transplant recipients infected with SARS-CoV-2SARS-CoV-2에 감염된 폐 이식 수혜자의 감시 생검에서 병리학적 소견의 진화Article Published on 2022-06-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Admission alteration biopsy Bronchiolitis bronchiolitis obliterans case sery coronavirus disease Coronavirus disease 2019 COVID-19 described determine Diagnosis died Evolution Follow-up GRADE heart histology Hospitalized ICU immunofluorescence inclusion criteria infected with SARS-CoV-2 intensive care intensive care unit large cohort lung Lung injury lung transplant lung transplantation non-transplant patient non-transplant patients one patient Organizing pneumonia outcome outcomes pathologic pathological finding pathology pathology. Patient positive Prognosis Protein recipient recipients rejection respiratory pathogen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid Society specimen subset Surveillance Symptomatic patients tested transbronchial Transplant Two patient two patients was performed [DOI] 10.1111/tid.13823 PMC 바로가기 [Article Type] Article
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis면역 시공간 환경의 단일 세포 전사체 프로파일링은 다균성 패혈증에서 수지상 세포 조절 프로그램을 보여줍니다Article Published on 2022-05-292022-09-11 Journal: Theranostics [Category] 치료제, [키워드] activated adopted alteration Analysis applied available data Cancer canonical CD4 cDCs characterized co-cultured comprehensive view conserved COVID-19 patients Cytometry demonstrated dendritic dendritic cell dendritic cells described determined by dissect experiment experiments expression Flow flow cytometry generate Genes heterogeneity Host immune response hyperinflammation identify IFNGR2 immune Immune cell immune cell types immune cells immunofluorescence Immunosuppression indicated inhibitory initiated Intracellular majority maturation morbidity multiplex immunofluorescence myeloid cells naïve natural killer observation organ dysfunction pathway Pathways progression promoted protein level Puncture rationale Regulatory regulatory T cells reveal scRNA-seq ScRNA-seq analysis Sepsis septic septic patients signaling pathway single-cell single-cell analysis single-cell analysis. Single-cell RNA sequencing specific type staining STAT3 subset T cell T cells tissue tissue sites Transcriptome unique upregulation [DOI] 10.7150/thno.72760 PMC 바로가기 [Article Type] Article