Greasing the inflammatory pathogenesis of viral pneumonias in diabetesReview Published on 2022-05-012023-07-07 Journal: Obesity Reviews [Category] COVID19(2023년), [키워드] adipocytes diabetes immunometabolism obesity SARS-CoV2 [DOI] 10.1111/obr.13415 PMC 바로가기 [Article Type] Review
The Influence of Obesity and Weight Loss on the Bioregulation of Innate/Inflammatory Responses: Macrophages and ImmunometabolismReview Published on 2022-01-302022-10-31 Journal: Nutrients [Category] Coronavirus, SARS, [키워드] absence adipose anti-inflammatory effect anti-inflammatory macrophage characterized COVID-19 Defense demonstrated Effect excessive inflammatory response Immunocompromise immunometabolism individual Infection Inflammation Inflammatory Inflammatory diseases Inflammatory response influence inherent innate response Intervention Loss low-grade inflammation Macrophage macrophages obese obesity pathogen question reduction in Research response responses Result susceptibility tissue viral infections weight weight loss [DOI] 10.3390/nu14030612 PMC 바로가기 [Article Type] Review
Modulation of Macrophage Immunometabolism: A New Approach to Fight InfectionsImmunology Published on 2022-01-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulated amino acid metabolism Bacterial contribute Defense develop drug Evidence Extracellular fatty acid oxidation function Glycolysis Host immune function Immunity immunometabolism Infection infections innate immune cell Macrophage macrophage activation metabolic pathway New pentose phosphate pathway phenotype potential therapy regulate respond SARS – CoV – 2 SARS-CoV2 infection Therapeutic strategies Therapeutics viral infection [DOI] 10.3389/fimmu.2022.780839 PMC 바로가기 [Article Type] Immunology
Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis아세테이트는 NLRP3 인플라마좀 및 해당작용-HIF-1α 축을 통해 폐포 대식세포에 의한 폐렴구균의 사멸을 개선한다.Original Research Published on 2022-01-202024-07-30 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] Alveolar macrophages IL-1β immunometabolism Innate immunity nitric oxide short chain fatty acid Streptococcus pneumoniae [DOI] 10.3389/fimmu.2022.773261 PMC 바로가기 [Article Type] Original Research
Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1Immunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2-deoxyglucose 2-DG binding blocked COVID-19 cytokine cytokine production dependent on Deprivation direct infection dose-dependent drug experiments Glucose Glycolysis hallmark hyperinflammation hyperinflammatory state immunometabolism implication increase in induce Inflammation Inflammatory cytokine Inflammatory response inhibit inhibited inhibition live SARS-CoV-2 metabolism metformin mitochondrial metabolism monocyte oxidative phosphorylation pro-inflammatory pro-inflammatory cytokines regulate rescued SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 strain severity spike Spike protein stimulated subunit suppresse suppressed the SARS-CoV-2 Treatment undergo upregulating viral spike protein WA1/2020 [DOI] 10.3389/fimmu.2021.733921 PMC 바로가기 [Article Type] Immunology
Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19Immunology Published on 2021-10-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute infection association cardiovascular disease Chronic kidney disease clinical study Comorbidity Complication Course COVID-19 COVID-19 progression develop diabetes Diabetes Mellitus disorder dysregulation example higher risk Host hypertension immune response immunometabolism immunopathy individual Intervention Kidney disease Meta-analysis metabolic disorder obese obesity pandemic patient cohort Prognosis recent variety viral infection [DOI] 10.3389/fimmu.2021.732913 PMC 바로가기 [Article Type] Immunology
Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potentialArticle Published on 2021-10-062023-06-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, [키워드] COVID-19 immunometabolism Lymphocytes metformin [DOI] 10.1016/j.biopha.2021.112230 PMC 바로가기 [Article Type] Article
Hospital mortality in COVID-19 patients in Belgium treated with statins, ACE inhibitors and/or ARBsObservational Study Published on 2021-09-022022-10-05 Journal: Human vaccines & immunotherapeutics [Category] SARS, 임상, [키워드] 28-day mortality 95% CI ACE ACE inhibitor ACE inhibitors ACEIs activity angiotensin receptor blocker Angiotensin receptor blockers ARB ARBs Belgium Case-control characterized clinical trial Combination combination treatment COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients determine drug Endothelial cell Endothelial dysfunction help hospital Hospital mortality hospitalized COVID-19 patients immunometabolism IMPROVE In-hospital maintain Mortality observational study pathogenesis of COVID-19 Propensity score receptor reduced reduction in statins survival treated Treatment unlikely Vaccine [DOI] 10.1080/21645515.2021.1920271 PMC 바로가기 [Article Type] Observational Study
Elevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action?Immunology Published on 2021-06-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Cytokine storm diabetes immunometabolism Impaired Inflammation interleukin-10 Level potentiation response SARS – CoV – 2 [DOI] 10.3389/fimmu.2021.677008 PMC 바로가기 [Article Type] Immunology
Reduction of host cell mitochondrial activity as Mycobacterium leprae’s strategy to evade host innate immunityarticle Published on 2021-05-312024-09-01 Journal: Immunological Reviews [Category] 한센병, [키워드] cholesterol free fatty acid and xenophagy HIF-1α immunometabolism Inflammasome LACC1 leprosy Parkin PKRN [Article Type] article