Docking-based virtual screening and identification of potential COVID-19 main protease inhibitors from brown algaeResearch article Published on 2021-12-012022-10-05 Journal: South African Journal of Botany [Category] 신약개발, [키워드] acute respiratory syndrome analysed cause Compound conditions coronavirus COVID-19 COVID-19 outbreak database Docking-based VS drug global public health health emergency identify immunomodulatory effects In-vitro Interaction limitation MERS morbidity and mortality outbreak overcome pandemic protease Protease inhibitor regimen reported SARS-CoV-2 screened seaweed Seven shown Structure-based virtual screening transmission potential viral disease Virtual screening virus World Health Organization [DOI] 10.1016/j.sajb.2021.06.033 [Article Type] Research article
Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19Pharmacology Published on 2021-11-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE analyzed Anti-inflammation Antiviral binding Cell Characteristics Chinese clinical symptom clinical trials component Coronavirus disease 2019 COVID-19 dry cough Effects expected Fever glycyrrhizin immunomodulatory effects IMPROVE Inflammatory factor inflammatory mediator inhibit interfere licorice mechanism of action mechanisms Mild moderate molecular mechanism outbreak pandemic pathogenesis of COVID-19 pathway Patient pharmacological Pharmacological Effects Potential Prevent respiratory diseases Shortness of breath significant difference significantly stimulated suggested Symptoms target therapeutic Topic Traditional traditional uses treat Treatment type I interferon Vaccine virus spike protein [DOI] 10.3389/fphar.2021.719758 PMC 바로가기 [Article Type] Pharmacology
Immunological and Preventive Effects of Hochuekkito and Kakkonto Against Coronavirus Disease in Healthcare Workers: A Retrospective Observational StudyPharmacology Published on 2021-11-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] abdominal discomfort activating Activation acute respiratory syndrome administration Against analyzed animal model antibodies biological property Cell changes in circulating Clinical data Clinical studies clinics compounds coronavirus coronavirus disease COVID-19 diarrhea Effect effective electronic medical records ENhance expected experiments expressing expression fatigue FIVE HCW HCWs healthcare worker Healthcare workers higher risk hochuekkito hospital iCoS immune cells immunological immunomodulation immunomodulatory effects increase in indicate induce Infection Infectious disease investigated kakkonto Kampo Kampo formulas Kampo medicine lymphocyte modulate myalgia NKG2A outbreak OX40 Patient patients populations presence of antibody Prevent PROTECT receptor Regulation Safe SARS-CoV-2 Side effect significant increase significantly increased specimen Stool study population surface markers T cell T cells tested TLR4 Toxicity worsening [DOI] 10.3389/fphar.2021.766402 PMC 바로가기 [Article Type] Pharmacology
Potential benefit of vitamin D supplementation in people with respiratory illnesses, during the COVID‐19 pandemicMini‐review Published on 2021-11-022022-11-01 Journal: Clinical and translational science [Category] COVID-19, MERS, [키워드] active form acute respiratory distress addition ARDS association benefit clinical Consequences Control coronavirus disease COVID‐19 COVID‐19 infection cytokine Cytokine storm Cytokines decrease deficiency Evidence Hospitalized immunomodulatory effects incidence increase in indicate Infection infections Lower respiratory tract mitigate Mortality offer outcome pandemic Patient Population Potential reduce reported Respiratory disease respiratory diseases respiratory illnesses risk serious complication severity susceptibility susceptible syndrome Tuberculosis vitamin D deficiency vitamin D level Vitamin D supplementation [DOI] 10.1111/cts.13044 PMC 바로가기 [Article Type] Mini‐review
Targeting the Pentose Phosphate Pathway for SARS-CoV-2 TherapyArticle Published on 2021-10-132022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] 2-deoxy-d-glucose addition Analysis Anti-SARS-CoV-2 Activity Antiviral antiviral therapy benfooxythiamine Bot changes in coronavirus disease COVID-19 COVID-19 patients effective generate Glycolysis host cell metabolism Immune cell immunomodulatory effects immunopathology IMPROVE indicated induce inhibited inhibiting inhibitor interfere metabolic drug metabolism outcome oxythiamine pandemic pathway pentose pentose phosphate pathway pharmacological proteomics data Regulation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2-infected cells targeting therapy TKT Treatment [DOI] 10.3390/metabo11100699 PMC 바로가기 [Article Type] Article
Combined Therapy of Ciclosporin Plus Favipiravir in the Management of Patients with Severe COVID-19, not Responding to Dexamethasone: A non-Controlled Prospective Trial덱사메타손에 반응하지 않는 중증 COVID-19 환자 관리에서 시클로스포린과 파비피라비르의 병용 요법: 비대조 전향적 시험Clinical Trial Published on 2021-10-012022-09-11 Journal: International immunopharmacology [Category] SARS, 임상, 치료제, [키워드] Antiviral calcineurin calcineurin inhibitors calculated carried characterized Ciclosporin clinical trial Combination Combined Confirmed COVID-19 patient confirmed COVID-19 patients Controlled controlled trials COVID-19 COVID-19 pandemic COVID-19 patient Dexamethasone dose Efficacy evaluate evaluated Favipiravir favorable effect ferritin Hospital stay ICU ICU admission immunomodulatory effects inhibitor Injections intensive care intensive care unit lung mechanical ventilation mortality rate Patient patients potential therapeutic agent potential therapeutic agents Prospective protocol respond Responding SARS-CoV-2 second dose significantly higher therapy Trial were assessed White blood cell White blood cells [DOI] 10.1016/j.intimp.2021.108043 PMC 바로가기 [Article Type] Clinical Trial
Clinical experience on umbilical cord mesenchymal stem cell treatment in 210 severe and critical COVID-19 cases in TurkeyClinical Trial Published on 2021-10-012022-10-05 Journal: Stem cell reviews and reports [Category] SARS, 임상, [키워드] 95% CI added administration age Biorender.com Cell clinical clinical experience Clinical outcome COVID-19 COVID-19 case COVID-19 patient COVID-19 patients Critical Critically ill Cytokine storm discharged downregulate Effect elevated evaluated group groups ICU immunomodulatory effects IMPROVE Intubated intubated patient intubation Linear regression analysis MSC MSCs organ Oxygenation parameter pathophysiology Patient patients patients hospitalized phase randomised risk Safe SARS-CoV-2 severe cases severe COVID-19 severe COVID-19 patient severe COVID-19 patients statistically significant stem cell Stem cell therapy. survival the cytokine storm therapeutic Therapeutic benefit Therapeutic treatment therapy tissue treated Treatment Turkey UC-MSC UC-MSCs umbilical [DOI] 10.1007/s12015-021-10214-x PMC 바로가기 [Article Type] Clinical Trial
Vitamin D and COVID-19: An Overview of Recent Evidence비타민 D와 코로나19: 최근 증거 개요Review Published on 2021-09-292022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive immune system benefit Consensus contagious contributing to coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dysfunction Effect effective Effects global pandemic Host Immunity immunomodulatory effect immunomodulatory effects Infection innate and adaptive immune system lead Medical research modulating Multiorgan Novel coronavirus outbreak poor prognosis prevention of COVID-19 priority progressed recent reported Research respiratory resulting review SARS-CoV-2 SARS-COV-2 infection the disease Treatment treatment of COVID-19 variant virus Vitamin D Vitamin D supplementation while [DOI] 10.3390/ijms221910559 PMC 바로가기 [Article Type] Review
Lacticaseibacillus paracasei DG enhances the lactoferrin anti-SARS-CoV-2 response in Caco-2 cellsLacticaseibacillus paracasei DG는 Caco-2 세포에서 락토페린 항-SARS-CoV-2 반응을 향상시킵니다Brief Report Published on 2021-08-072022-09-11 Journal: Gut Microbes [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral immunity Caco-2 Caco-2 cell cell line Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 distress ENhance epithelial epithelial cells exhibit expression expression of gene gastrointestinal tract global pandemic immune immunomodulatory effect immunomodulatory effects in vitro inhibited intestinal intestinal epithelial cells investigated involved lactobacilli lactoferrin lead microorganism microorganisms prevented Probiotics proinflammatory gene proinflammatory genes Prophylactic Protective respiratory respiratory distress SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro shown significantly Strains Symptom triggered [DOI] 10.1080/19490976.2021.1961970 PMC 바로가기 [Article Type] Brief Report
Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic TreatmentPhysiology Published on 2021-08-032022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] adaptive Amino acid amino-acid sequence dependency antibody antibody diversification B-cell candidate component consequence COVID-19 Critical defined determinant disease effective elicited epitope vaccines Evidence Evolution example explain gene sequence Genome glycosylation help highlight human cell humoral immune response hypothese immune response immune system Immunity immunogenic peptides immunomodulatory effects Implications Interpretation mechanism natural infection neutralizing antibody pandemic patient groups platform post-translational modification prophylactic treatment rarely recognized immune responses Safe SARS-CoV-2 SARS-COV-2 infection sequence somatic mutations Structural variation the vaccine translational Trial unique Vaccine design virus [DOI] 10.3389/fphys.2021.624675 PMC 바로가기 [Article Type] Physiology