Neutrophil Extracellular Trap Formation Potential Correlates with Lung Disease Severity in COVID-19 PatientsArticle Published on 2022-04-012023-07-07 Journal: Inflammation [Category] COVID19(2023년), [키워드] Elastase IL-8 Immunophenotyping SARS-CoV-2 SIRS [DOI] 10.1007/s10753-021-01585-x PMC 바로가기
Cellular and humoral responses to SARS-CoV-2 vaccination in immunosuppressed patients면역 억제 환자에서 SARS-CoV-2 백신 접종에 대한 세포 및 체액 반응Article Published on 2022-03-012022-09-11 Journal: Cellular immunology [Category] SARS, 치료기술, [키워드] Activation anti-spike antibodies B-cell BNT162b2 BNT162b2 mRNA CD8 ChAdOx1 ChAdOx1 nCoV-19 cohorts comparable COVID-19 cytokine Cytokines demonstrated depleting detectable difference Efficacy elicited haematological malignancies haematological malignancy healthy healthy volunteers highest Humoral response humoral responses immunodominance immunogenic immunological responses Immunophenotyping Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppression immunosuppressive immunosuppressive therapy less Longevity Lower memory naïve no significant differences non-responder participant Participants Patient patients treated phenotype preserved protective immunity receiving renal responders response SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines seroconvert serological seropositive Seropositivity significant difference T-cell T-cell ELISpot T-cell Response T-cell responses Th1 cytokine therapy Transplant Vaccinations vaccine immunogenicity vaccine response vaccine responses were used [DOI] 10.1016/j.cellimm.2022.104501 PMC 바로가기 [Article Type] Article
Atypical lymphoid cells circulating in blood in COVID-19 infection: morphology, immunophenotype and prognosis valueCOVID-19 감염에서 혈액에서 순환하는 비정형 림프 세포: 형태, 면역 표현형 및 예후 값Article Published on 2022-02-012022-09-11 Journal: Journal of Clinical Pathology [Category] 바이오마커, 치료기술, [키워드] Accuracy activated analysed Analysis approach Atypical lymphocyte automatically Blood blood sample Blood samples blue CD4 CD8 T cells Characteristics circulating classical clinical CNNs Convolutional neural network Convolutional neural networks COVID-19 COVID-19 patient COVID-19 patients Cytometry cytoplasm D-dimer develop Digital image effector memory ENhance Evolution filtration rate glomerular filtration rate Haemoglobin Immunophenotyping Laboratory lymphocyte Lymphocyte count lymphocyte counts Lymphocytes lymphoid cell Morphological morphological and microscopic findings morphology Neutrophils nucleus outcome Patient patients died patients without COVID-19 procalcitonin Prognosis Protein reactive reported sensitivity specificity T cells these cell These cells total protein virus-specific T cell viruses was performed were used [DOI] 10.1136/jclinpath-2020-207087 PMC 바로가기 [Article Type] Article
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infectionSARS-COV-2 감염 후 몇 달 후 말초 면역계의 장기 섭동Research Article Published on 2022-01-142022-09-01 Journal: BMC Medicine [Category] SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis anti-RBD Anti-RBD IgG Antibody responses Blood cellular controls convalescent convalescent individual convalescent individuals Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID COVID-19 Critical CXCR3 deep disease severity Effects explain follicular Gene Expression healthy healthy controls IgG responses immune population immune response immune responses immune system Immunity Immunophenotyping in some increasingly individuals Infection Long COVID Mild moderate molecular Monocytes Neutrophils NK cells pandemic PASC Patient persistence Perturbation plethora Post COVID-19 condition Post-acute sequelae of COVID-19 (PASC) Post-infection referred to regulatory T cells reported Research respiratory respiratory virus response responsible Result RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significant differences supplementary material Symptom syndrome T cell T cells T helper transcriptional transcriptional level Transcriptome uninfected [DOI] 10.1186/s12916-021-02228-6 PMC 바로가기 [Article Type] Research Article
Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology가용성 CD24를 사용한 치료는 COVID-19 관련 전신 면역병리를 약화시킵니다Clinical Trial Published on 2022-01-102022-09-12 Journal: Journal of Hematology & Oncology [Category] 임상, 진단, [키워드] acute respiratory syndrome coronavirus Analysis anti-inflammatory agent anti-inflammatory agents Anti-viral Antibody Response approach attenuate binding blunt cause CD24 CD24Fc CD4 CD56 CD8 cellular compartments chemokine chemokines Clinical characteristics Clinical efficacy coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity cytokine Cytokine score Cytokines damage damage-associated molecular pattern Damage-associated molecular patterns demonstrated downstream enrolled epithelial cells Extracellular flow cytometry heat shock proteins homeostasis homology Immune homeostasis immunopathology Immunophenotyping induce infected individuals Inflammatory response Lung epithelial cells Natural killer cells Pathogenesis pathway Patient patients with COVID-19 performed Peripheral blood peripheral blood samples phosphatase placebo group pro-inflammatory cytokine Protein Randomized Release respiratory Result return SARS-CoV-2 SARS-CoV-2-infected individuals severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity shown Siglec10 significantly Soluble CD24 supplementary material systemic cytokine response systemic inflammation T cell T cells therapeutic therapeutic efficacy Treatment Trial with COVID-19 [DOI] 10.1186/s13045-021-01222-y PMC 바로가기 [Article Type] Clinical Trial
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe IndividualsImmunology Published on 2021-11-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] abnormality active infection adaptive immune responses Adults CD8+ T cells Cell comparison convalescent COVID-19 cytokine cytokine profile elevated endothelial growth factor hepatocyte growth factor immune immune correlate immune recovery immune response Immunophenotyping individual Inflammation low-density lymphopenia Mild neutrophil counts Neutrophils NKT non-classical monocyte persistent pro-inflammatory cytokine proportion SARS – CoV – 2 SARS-COV-2 infection severe COVID-19 severely infected patient severity survivor T cells Vascular virus clearance [DOI] 10.3389/fimmu.2021.710217 PMC 바로가기 [Article Type] Immunology
Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients중환자 COVID-19 환자의 치명적인 결과의 면역 상관 관계 식별Research Article Published on 2021-09-162022-09-10 Journal: PLoS Pathogens [Category] 바이오마커, 진단, [키워드] 95% CI abnormality Activation CCL2 CD8 cell activation cells chemokines controls correlated COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical Critical illness Critically ill Critically ill patient critically ill patients CXCL10 cytokine Cytokines death death in COVID-19 demonstrated disease severity driven by driver dysfunction ECMO element elements elevated examined fatal COVID-19 GM-CSF Health care health care workers healthy hierarchy ICU ICU patient ICU Patients identification identify IFNα IL-6 immune immune correlate Immunophenotyping in-depth analysis independent Infection Inflammatory response Influenza influenza infection Intervention measure Neutralizing antibodies outcome pathway Patient performed Potential biomarker pro-inflammatory response prognostic indicator Proteins reveal RNA-sequencing SARS-COV-2 infection serum Serum protein serum proteins shift Single-cell RNA-sequencing T cell T cell activation T cell responses T cells target unique Viral Viral antigen [DOI] 10.1371/journal.ppat.1009804 PMC 바로가기 [Article Type] Research Article
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal studyCovid-19 코호트 (IMPACC)에서의 면역 표현형 평가 : 전향 적 종단 연구Multicenter Study Published on 2021-08-102022-09-10 Journal: Science Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] analyses assays assessment biologic Biomarker Biomarkers Blood clinical Clinical and laboratory data clinical criteria Course COVID-19 COVID-19 cohort description Disease progression effective feature generate genomic harmonization hospitalized patient hospitalized patients Host immune response host immune responses hypothese hypotheses identify immune responses Immunophenotyping Laboratory laboratory data longitudinal study manifestation metabolomic multicenter multisite pathogen processing proteomic protocol protocols Radiographic recruitment respiratory secretion severity Study design susceptibility with COVID-19 [DOI] 10.1126/sciimmunol.abf3733 PMC 바로가기 [Article Type] Multicenter Study
Combination of a Sindbis-SARS-CoV-2 Spike Vaccine and αOX40 Antibody Elicits Protective Immunity Against SARS-CoV-2 Induced Disease and Potentiates Long-Term SARS-CoV-2-Specific Humoral and T-Cell Immunitysindbis-sars-cov-2 스파이크 백신과 αOX40 항체의 조합은 SARS-COV-2 유도 질환에 대한 보호 면역을 유도하고 장기 SARS-COV-2- 특이 적 유머 및 T- 세포 면역을 강화시킨다.Immunology Published on 2021-07-292022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] αOX40 activated T cells Against alphavirus vaccine Analysis antibody approach can be used caused cellular coronavirus coronavirus SARS-CoV-2 COVID-19 pandemic COVID19 develop dose effective effective vaccine effector memory effort elicit elicited expressing functions generate hACE2 human ACE2 receptor immune protection immune response immunization immunize Immunophenotyping immunostimulatory induced Infection infection assay inhibit long-lasting neutralizing antibodies long-lasting neutralizing antibody lung tissue mice MOST mounted Neutralizing antibodies OX40 Pathogens platform profiles protective immunity Protein binding provided reprogramming RNA robust SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 spike protein SARS-CoV-2 vaccine sera Sindbis virus vaccine spike Spike protein synergistic combination SARS-CoV-2 vaccine strategy T cell T cells T-cell Response T-cell responses the SARS-CoV-2 the vaccine Transcriptome transgenic mice Vaccine vaccine platform variant variants [DOI] 10.3389/fimmu.2021.719077 PMC 바로가기 [Article Type] Immunology
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia뚜렷한 면역학적 특징은 심각한 COVID-19를 SARS-CoV-2에 의해 유발되지 않은 치명적인 폐렴과 구별합니다.Comparative Study Published on 2021-07-132022-09-11 Journal: Immunity [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, [키워드] adaptive alteration Analysis binding Biomarker cascade Cell change circulating ClinicalTrials COVID-19 COVID-19 patient Critical Cytometry driven by feature flow cytometry Frequency GM-CSF high-dimensional single cell analysis HLA HLA typing ICU patient ICU Patients immune Immune profile immune profiling immune signature Immunity immunological immunopathology Immunophenotyping Inflammatory response integration interfere longitudinal NKT outcome paralysis Patient peptide peptide binding strength peptides Pneumonia predicted Predictive SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides severe COVID-19 Single Cell single-cell spectral flow cytometry. T cell the patient translation Treatment strategies treatment strategy virus recognition [DOI] 10.1016/j.immuni.2021.05.002 PMC 바로가기 [Article Type] Comparative Study