Lipid rafts as viral entry routes and immune platforms: A double-edged sword in SARS-CoV-2 infection?Review Published on 2022-03-042023-07-01 Journal: Biochimica et biophysica acta. Molecular and cell [Category] COVID19(2023년), SARS, [키워드] anticoagulant drugs antiviral drugs COVID-19 immunosuppressive drugs Lipid rafts lipid-lowering drugs monoclonal antibodies SARS-CoV-2 [DOI] 10.1016/j.bbalip.2022.159140 PMC 바로가기 [Article Type] Review
Response to Vaccines in Patients with Immune-Mediated Inflammatory Diseases: A Narrative ReviewReview Published on 2022-02-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activating acute respiratory syndrome Affect antibody appear attenuate B-cell biologic Biologic therapy coronavirus CTLA-4 described dose Efficacy evaluated fusion protein healthy individuals IL-17 IL-6 immune response immune system Immune-mediated inflammatory disease Immune-mediated inflammatory diseases immunosuppressants immunosuppressive immunosuppressive drugs impair increased risk Infection Inflammatory bowel disease inhibitor inhibitors integrin Interleukins knowledge limit Live attenuated vaccine narrative Necrosis pathogenic Patient patients patients receiving treatment patients treated protective immune response protective response recommendation reduced replicate response responses review rheumatoid arthritis risk of infection Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine severe disease Therapies therapy TNF treat Treatment vaccination Vaccine vaccine response Vaccines [DOI] 10.3390/vaccines10020297 PMC 바로가기 [Article Type] Review
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients감염 또는 세 번째 mRNA 백신 접종은 신장 이식 수혜자의 SARS-CoV-2에 대한 중화 항체 반응을 유발합니다Research Article Published on 2022-02-012022-09-14 Journal: Science Translational Medicine [Category] MERS, SARS, 임상, 진단, [키워드] acting acute respiratory syndrome administration Anti-RBD IgG Cell cell interaction cellular characterized cohorts coronavirus coronavirus disease COVID-19 description dose elicit follicular humoral immune response IgG antibody Immunosuppression immunosuppressive immunosuppressive drugs IMPROVE independent individual infected with SARS-CoV-2 Infection kidney transplant recipient kidney transplant recipients Mortality mRNA vaccine Neutralizing Neutralizing antibody response Neutralizing titer Patient patients patients treated Prevent provided RBD receive recipients regimen rejection response restored SARS-CoV-2 suggested symptomatic T cell response Tfh therapeutic took place Transplant two group two-dose regimen vaccination Vaccine Vaccines [DOI] 10.1126/scitranslmed.abl6141 PMC 바로가기 [Article Type] Research Article
Impact of COVID-19 in immunosuppressive drug-naïve autoimmune disorders: Autoimmune gastritis, celiac disease, type 1 diabetes, and autoimmune thyroid disease면역 억제 약물-나이브자가 면역 장애에서 Covid-19의 영향 :자가 면역 위염, 체강 질병, 1 형 당뇨병 및자가 면역 갑상선 질환Article Published on 2022-01-012022-08-31 Journal: Pediatric allergy and immunology : official public [Category] SARS, 치료제, [키워드] adverse outcomes Autoimmune Autoimmune diseases Autoimmune disorders autoimmune gastritis autoimmune thyroid disease Autoimmunity celiac disease comparable conducted COVID-19 diabete diabetes died disease gastritis General population Hospitalization immunosuppressive immunosuppressive drugs Impact indicated lombardy Mild molecular Nasopharyngeal swab nasopharyngeal swabs outcome Patient patients patients required hospitalization performed positive COVID-19 reported risk SARS-CoV-2 SARS-COV-2 infection serology Seven susceptibility T1D telephone Thyroid thyroid disease Treatment Type 1 diabetes vaccination Vaccination Status [DOI] 10.1111/pai.13646 PMC 바로가기 [Article Type] Article
Association Between Chronic Use of Immunosuppresive Drugs and Clinical Outcomes From Coronavirus Disease 2019 (COVID-19) Hospitalization: A Retrospective Cohort Study in a Large US Health SystemCoronavirus Disease 2019 (COVID-19) 입원 : 미국의 대규모 미국 건강 시스템에서의 후 향적 코호트 연구의 만성 사용 및 임상 결과 사이의 연관성Article Published on 2021-12-062022-08-31 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval Admission adults hospitalized chronic clinical Clinical outcome clinical outcomes cohort study coronavirus disease Coronavirus disease 2019 COVID-19 defined discharge drug entire cohort hazard ratio health system Hospital admission Hospital mortality Immunosuppressed Immunosuppression immunosuppressive drug immunosuppressive drugs IMPROVE in-hospital mortality individual interquartile range laboratory-confirmed mechanical ventilation mechanism median age Medicines mycophenolate mycophenolate mofetil no significant difference no significant differences Patient Prednisone prescription medicines. Prescriptions Probability Propensity score retrospective cohort study risk severity study period survived System tacrolimus the median Treatment with COVID-19 [DOI] 10.1093/cid/ciaa1488 PMC 바로가기 [Article Type] Article
Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 VaccinesResearch Article Published on 2021-11-102022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, [키워드] age and gender antibodies antibody antibody kinetics Antibody Response average binding domain BNT162b2 BNT162b2 vaccine changes in clinically clinician Cohort COVID-19 COVID-19 pandemic defined difference dosage dose regimen elicited first dose Follow-up human cell IgG IgG antibody IgG response immune system immunization immunosuppressive drugs linear Moderna mRNA mRNA platform mRNA vaccine mRNA-1273 mRNA-1273 vaccine overcome participant peaked Pfizer/BioNTech powerful tool Prospective regimens regression modeling remained response S-protein SARS-CoV-2 SARS-CoV-2 vaccine second dose seroconverted serological Serologically seronegative participants significantly higher Spike protein the SARS-CoV-2 the vaccine titer translated vaccination Vaccine Vaccines virus spike protein was used were measured [DOI] 10.1128/Spectrum.01162-21 PMC 바로가기 [Article Type] Research Article
Antibody responses to the SARS-CoV-2 vaccine in individuals with various inborn errors of immunity다양한 선천성 면역 오류가 있는 개인의 SARS-CoV-2 백신에 대한 항체 반응Article Published on 2021-11-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] adverse event adverse events affected age anti-S anti-S IgG anti-S IgG levels antibody Antibody Response Antibody titer Antibody titers Autoimmune B cells B-cell baseline candidiasis Care CD19 CD3 Cohort cohort of patient completion controls counseling COVID-19 COVID-19 vaccine Diagnosis dose evaluate Genetic Health Health care immune immune suppressants Immunity immunization immunization schedule immunized immunogenicity immunomodulators immunosuppressive drug immunosuppressive drugs Inborn errors inborn errors of immunity individual information Jak jak inhibitors janssen Johnson & Johnson less luciferase Luciferase immunoprecipitation system median medical records mRNA vaccine Patient patients plasma rate of seroconversion reported rituximab Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination second dose Seroconversion single dose subsequent T cells the SARS-CoV-2 therapy These data thymoma Treatment Vaccinating Vaccine was collected were measured [DOI] 10.1016/j.jaci.2021.08.016 PMC 바로가기 [Article Type] Article
Possibility of deterioration of respiratory status when steroids precede antiviral drugs in patients with COVID-19 pneumonia: A retrospective studyCOVID-19 폐렴 환자의 스테로이드가 항 바이러스 약물보다 우선시 될 때 호흡기 상태의 악화 가능성 : 후 향적 연구Observational Study Published on 2021-09-022022-09-10 Journal: PLoS ONE [Category] SARS, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Administering administration Admission aggravate Analysis Anti-inflammatory antiviral drug antiviral drugs Asymptomatic caused consecutive patient consecutive patients coronavirus coronavirus disease COVID-19 COVID-19 pneumonia Deterioration develop disease disease severity duration of hospitalization early disease ECMO Effectiveness evaluate Exacerbation extracorporeal membrane oxygenation ICU ICU admission immunosuppressive drugs incidence rate intensive care intubation Mild Mild disease Most patients observational study Patient patients with COVID-19 Pneumonia respiratory Result retrospective Retrospective study risk severe acute respiratory syndrome Coronavirus severe disease significantly higher significantly lower single-center steroid Steroids study period symptom onset Symptomatic treatment therapeutic agents two group two groups with COVID-19 [DOI] 10.1371/journal.pone.0256977 PMC 바로가기 [Article Type] Observational Study
Altered platelet and coagulation function in moderate-to-severe COVID-19Article Published on 2021-08-112022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] absence Altered antibodies Anticoagulant bleeding Blood blood clot C-reactive protein clot Coagulation coagulation function Coagulopathy Combination Comorbidities consumption coagulopathy contraction correlated Course COVID-19 decrease disease severity Disseminated intravascular coagulation distribution dysfunction erythrocyte examined Hemostasis hemostatic disorder hypercoagulability immunosuppressive drugs in vitro Infection Local manifested moderate moderate-to-severe COVID-19 mortality risk Obstructive parameters Patient patients patients with moderate Platelet polyhedral porous Prognostic markers Prophylaxis prothrombotic receiving severe COVID-19 systemic inflammation thrombotic complication [DOI] 10.1038/s41598-021-95397-6 PMC 바로가기 [Article Type] Article
COVID-19 vaccines in multiple sclerosis treated with cladribine or ocrelizumab클라드리빈 또는 오크렐리주맙으로 치료한 다발성 경화증의 코로나19 백신Article Published on 2021-07-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] SARS, 진단, [키워드] antibodies approval COVID-19 COVID-19 vaccine Disease modifying therapy dose Efficacy immune response immunosuppressive drugs Lymphocyte count Multiple multiple sclerosis patients patients treated the timing the vaccine treated Treatment vaccination Vaccine [DOI] 10.1016/j.msard.2021.102983 PMC 바로가기 [Article Type] Article