Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike proteinArticle Published on 2022-09-142022-11-15 Journal: Cell Host & Microbe [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 receptor acute respiratory syndrome amino acid substitution Cell cell display coronavirus COVID-19 Effect Epitopes expression flow cytometry glycoprotein high throughput Host immune evasion implicated INDEL mechanism molecular Mutation mutations N-terminal neutralizing antibody nonsynonymous omicron Receptor binding domain repeated S2 domain SARS-CoV-2 spike mutation Spike protein Spread the SARS-CoV-2 the spike protein Transmissibility variant variants of concern variety viral glycoprotein. VOCs [DOI] 10.1016/j.chom.2022.07.016 PMC 바로가기
Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomesArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] abundance acute phase acute respiratory syndrome Alter Analysis approach approach assays body mass index C-reactive protein circulating clinical decision Compromised coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patient creatinine criterion Critical Critically ill cut-off value determine disease disrupt driven by dysregulation energy-related metabolites evaluated Extracellular fluorometric quantification Glucose Health Host Host immune response immune response implicated IMPROVE Increased independent predictor Infection Lactate mechanisms metabolism metabolite metabolomics mitochondrial outcome outcomes Patient Potential biomarker Prognosis Prognostic marker provided pyruvate quantification Quantitative recruited risk SARS-CoV-2 SARS-COV-2 infection semi-targeted metebolomics. serum severe COVID-19 illness severity Signaling Stratification Support validation cohort virus [DOI] 10.3389/fimmu.2022.912579 PMC 바로가기
SARS-CoV-2 can infect human embryosArticle Published on 2022-09-142022-11-15 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] ACE2 antibody canonical Cell cell entry cells co-expressed COVID-19 COVID-19 pandemic Effect Embryo embryogenesis embryos Factor fluorescent glycoprotein Health human tissue identify immunofluorescence implicated implication infect Infection observé organ pandemic Pregnancy reporter reproductive resulting RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection spike Spread susceptibility susceptible Symptom target tissue TMPRSS2 viral entry virions pseudotyped [DOI] 10.1038/s41598-022-18906-1 PMC 바로가기
TNFRSF1B and TNF Variants Are Associated With Differences in Levels of Soluble Tumor Necrosis Factor Receptors in Patients With Severe COVID-19Article Published on 2022-09-132022-11-16 Journal: The Journal of Infectious Diseases [Category] 변종, [키워드] association coronavirus disease COVID-19 COVID-19 severity determine difference ELISA evaluated exhibited expression Factor genetic study Genetic variant genetic variants genetics Genetics. Genotype genotypes implicated IMV Invasive mechanical ventilation Level no difference paO2/fiO2 Patient patients patients with COVID-19 plasma plasma sample receptor severe COVID-19 severity TNF TNF-α TNFR1 TNFR2 TNFRSF1A TNFRSF1B Tumor tumor necrosis factor-α variant was used were used with COVID-19 [DOI] 10.1093/infdis/jiac101 PMC 바로가기
Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019Article Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Activation acute respiratory syndrome addition analysis and antibodies antibody C1q circulating classical classical pathway common cold common cold coronavirus common cold Coronaviruses complement complement system. coronavirus coronavirus disease correlated COVID-19 Critical demonstrated develop disease disease severity greater healthy control hospitalized patient IgG response immune complex immune complex Immunoglobulin Immunoglobulin G implicated mechanism moderate modify outcome overactivation Pathogenesis Patient patients with COVID-19 plasma response responsible RNA SARS-CoV-2 severe COVID-19 severe patients severity systemically therapeutic strategy with COVID-19 [DOI] 10.1093/infdis/jiac091 PMC 바로가기
Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical ExposuresCOVID-19 위험과 환경 화학 물질 노출의 교차점에서의 후성 유전학Review Published on 2022-09-012022-09-11 Journal: Current environmental health reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter among others Chemical contaminant COVID-19 COVID-19 susceptibility disease disrupting Drawing Endocrine Environmental chemicals Epigenetic epigenetic modification epigenetics Evidence exposure host antiviral responses host response immune pathway immune system Immunity Immunologic memory immunomodulation implicated include Infectious disease Infectious disease. Inflammation Intersection involved mechanism memory Modification molecular mechanism Numerous Pathways recent Recognition Regulation risk SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severity Specific susceptibility the SARS-CoV-2 virus viral entry [DOI] 10.1007/s40572-022-00353-9 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and Skin: New Insights and PerspectivesArticle Published on 2022-08-312022-11-15 Journal: Biomolecules [Category] SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 mRNA ACE2 receptor adopted Affect appear article association cell population Cohort conducted control group COVID-19 database dermatopathology disease eccrine sweat glands epidermal expression fibroblast Future globe health system healthy controls immune immunolabeling implicated inclusion criteria insight literature review manifestation Manifestations mechanism molecular New nine no significant difference pandemic performed receptor report researcher Respiratory system SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2-positive patient skin biopsies skin. staining statistically TMPRSS2 Topic two groups [DOI] 10.3390/biom12091212 PMC 바로가기
Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study코로나바이러스 질병 2019(COVID-19) 동안 어린이의 폐렴구균 질병 감소, 지속적인 폐렴구균 감염에도 불구하고 계절성 호흡기 바이러스 억제와 관련된 이스라엘의 유행성: 전향적 코호트 연구Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] activity Adenovirus adjusted age alveolar Chain Reaction chest X-ray chest X-rays children Cohort colonization COVID-19 COVID-19 pandemic Decline declined density disappearance disease distribution Ethnicity expected followed by human metapneumovirus Hypothesis implicated incidence incidence rate Influenza influenza viruses invasive pneumococcal disease lockdown lower respiratory infections magnitude métapneumovirus monthly rate nasopharyngeal Nonpharmaceutical interventions nonpneumonia parainfluenza Pathogens persistent pneumococcal pneumococcal pneumoniae pneumococcus Pneumonia pneumoniae polymerase chain polymerase chain reaction Prevalence Previous studies previous study Prospective reduced reduction reductions respiratory respiratory infection respiratory infections respiratory syncytial virus respiratory virus respiratory viruses respiratory viruses. resulting rhinovirus SARS-CoV-2 seasonal serotype suppression Surveillance Transmission [DOI] 10.1093/cid/ciab1014 PMC 바로가기 [Article Type] Article
Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapyArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료제, [키워드] ACE2 ACE2 receptors acute respiratory syndrome Analysis Anti-viral antiviral activity article Ashwagandha build Clinical management Compound coronavirus Coronavirus disease 2019 COVID-19 Critical disease drug Drug discovery flu help Immune homeostasis implicated Infection Inflammation information inhibit knowledge management MPro multiple organs organs other compounds pandemic parameter Patient patients Population pro-inflammatory cytokine protease provided Regulation SARS-CoV-2 SARS-COV-2 infection secure Side effect Standardization targeted therapy targeted therapy. the patient Treatment Vaccine virus was performed Withania somnifera [DOI] 10.3389/fcimb.2022.933824 PMC 바로가기
Anti-neuronal antibodies against brainstem antigens are associated with COVID-19Article Published on 2022-08-112022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Affect AIFM1 antibody Antigen appear assisted ventilation Autoimmunity Brainstem Control controls Course COVID-19 patient COVID-19 patients DAB1 determine diagnostic Disabled Economy elevated Encephalitis epitope Epitopes finding foundation funding Germany Greifswald group help homolog hypothesised IgG IgG and IgM IgG level IgM implicated in both groups initiative intensive care Invasion long-COVID marker Medicine Microarray Mild Occurrence pathogenic pathway Patient peptide epitope predicted responsible SARS-CoV-2 serum severe disease severely ill patient significantly state Support SURF1 the disease therapeutic understanding university unlikely with COVID-19 [DOI] 10.1016/j.ebiom.2022.104211 [Article Type] Article