Novel Engineered SARS-CoV-2 HR1 Trimer Exhibits Improved Potency and Broad-Spectrum Activity against SARS-CoV-2 and Its Variants신규 설계된 SARS-CoV-2 HR1 삼량체, SARS-CoV-2 및 그 변이체에 대해 향상된 효능 및 광범위한 활성을 나타냄Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activities activity adopted affinity antibodies binding affinity C terminus caused cell-cell fusion develop domain effective Effectiveness foldon foundation fusing fusion fusion inhibitor global public health HR1 HR1 domain Improved increased the risk information inhibit inhibit SARS-CoV-2 inhibitor inhibitors inhibitory inhibitory activity limit MERS MERS-CoV MERS-CoV pseudoviruses motif much higher Multiple NAbs Neutralizing antibodies neutralizing antibody novel pandemic of COVID-19 peptide Peptide inhibitor Peptide Inhibitors peptides potency provide pseudoviruses reported S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Spread the S protein the SARS-CoV-2 theory treating SARS-CoV-2 infection trimer trimeric Vaccine variants viral infection viral S protein viral variant Viral variants VOCs [DOI] 10.1128/jvi.00681-22 PMC 바로가기 [Article Type] Article
Improved HPLC method for the determination of ribavirin concentration in red blood cells and its application in patients with COVID-19적혈구 내 리바비린 농도 측정을 위한 개선된 HPLC 방법 및 COVID-19 환자에 대한 적용Article Published on 2022-07-012022-09-11 Journal: Biomedical chromatography : BMC [Category] 치료제, [키워드] addition Adverse drug reactions Anemia antiviral drug Blood changes in Concentration correlation coefficient COVID-19 declined determine Efficacy erythrocyte hematocrit hematological parameter hematological parameters hemoglobin HPLC Improved Interim linear lowest Patient patients with COVID-19 phosphatase phosphorylated ranged red blood cell red blood cells ribavirin synthetic the patient [DOI] 10.1002/bmc.5370 PMC 바로가기 [Article Type] Article
Research on Mask-Wearing Detection Algorithm Based on Improved YOLOv5개선된 YOLOv5 기반 마스크 착용 감지 알고리즘 연구Article Published on 2022-06-292022-09-11 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, 치료제, [키워드] Accuracy Algorithm Attention average baseline bidirectional BiFPN complex contagious Coordinate Coordinate Attention COVID-19 Critical decrease detection distance Factor feature IMPROVE Improved introduced Mask mechanism object detection overlapping replaced Spread Stress suppression targets union virus YOLOv5 [DOI] 10.3390/s22134933 PMC 바로가기 [Article Type] Article
Improved Analysis of COVID-19 Influenced Pneumonia from the Chest X-Rays Using Fine-Tuned Residual Networks미세 조정된 잔류 네트워크를 사용하여 흉부 X선에서 코로나19 영향 폐렴에 대한 향상된 분석Article Published on 2022-06-162022-09-11 Journal: Computational Intelligence and Neuroscience [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy addressed Analysis Antigen approach Chest chest X-ray Chest X-ray images chest X-rays CNN contagious Convolutional neural network COVID COVID-19 Critical CXR dataset demonstrated Diagnosis effective Epidemic examined Genetic highest IMPROVE Improved indicated individual instance network occurred outcome past positive positive individuals Prevent reached reduction in cases remained residual resulting RT-PCR screened time-consuming virus weakness X-ray [DOI] 10.1155/2022/9414567 PMC 바로가기 [Article Type] Article
Chasing LDL cholesterol to the bottom — PCSK9 in perspective Reviews Published on 2022-06-152022-10-05 Journal: The Pan African Medical Journal [Category] 유전자 메커니즘, [키워드] alleviate Atherosclerosis atherosclerotic cardiovascular disease cardiovascular risk combating Concentration contribute events Health Improved Intervention investigators LDL LDL cholesterol LDL-C Low-density lipoprotein Measures notable outcome PCSK9 Perspective Prevent recent reflect therapeutic therapy [DOI] 10.1038/s44161-022-00085-x [Article Type] Reviews
Remdesivir for the treatment of patients hospitalized with COVID-19 receiving supplemental oxygen: a targeted literature review and meta-analysis산소 보충을 받고 있는 COVID-19로 입원한 환자의 치료를 위한 렘데시비르: 표적 문헌 검토 및 메타 분석Review Published on 2022-06-102022-09-11 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] baseline Controlled trial controlled trials credible interval CrI Efficacy HFO High-flow oxygen hospitalized patient hospitalized patients IMPROVE Improved literature review low-flow oxygen Meta-analysis Mortality need for oxygen Network meta-analysis NIV NMA NMAs Non-invasive non-invasive ventilation oxygen oxygen support Patient patients patients hospitalized performed receiving Remdesivir requiring supplemental oxygen risk risk ratio subgroups supplemental oxygen Support supportive care Treatment with COVID-19 [DOI] 10.1038/s41598-022-13680-6 PMC 바로가기 [Article Type] Review
Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation: An Update From the COV-AD Study3차 1차 SARS-CoV-2 예방접종 후 혈청유병률 증가 및 항체 반응 개선: COV-AD 연구의 업데이트Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Anti-spike antibody Antibody Response AstraZeneca B.1.1.529 cellular immunity cellular response ChAdOx1 ChAdOx1 nCoV-19 cohort of patient COVID-19 cross-reactive CVID deficiency detectable determine dose ELISA ELISpot assays ENhance enrolled glycoprotein healthy control healthy controls heterogeneous heterologous vaccine humoral Humoral immunity immunodeficiency immunogenicity Improved Inborn errors inborn errors of immunity Increased individual initial magnitude mounted neutralisation neutralising no differences participant Pfizer Primary Immunodeficiency remained response SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine secondary antibody secondary immunodeficiency Seroconversion serological response seronegative Seroprevalence significantly increased significantly lower significantly more Support T cell T cell response the antibody response the SARS-CoV-2 These data vaccination Vaccine vaccine dose vaccine doses variant widespread [DOI] 10.3389/fimmu.2022.912571 PMC 바로가기 [Article Type] Article
T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severityT 세포 수용체 시퀀싱은 이전 SARS-CoV-2 감염을 식별하고 중화 항체 및 질병 중증도와 상관관계가 있습니다Article Published on 2022-05-232022-09-12 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adaptive Biotechnologies Adaptive immunity antibody blood sample breadth conducted correlated COVID-19 Decline diagnostics difficulty breathing disease severity evaluated Fever Frederick greater Hospitalization humoral identify immune response Improved individual induce Infection Infectious disease initial less magnitude NAb neutralizing antibody NIAID protective immunity response SARS-CoV-2 SARS-COV-2 infection sensitivity Sequencing serology serology test severe disease significantly Society Support T cell T cell receptor T cell response T cell responses TCR transplantation Trial undetectable [DOI] 10.1172/jci.insight.150070 PMC 바로가기 [Article Type] Article
Improved methods for the detection and quantification of SARS-CoV-2 RNA in wastewater폐수에서 SARS-CoV-2 RNA의 검출 및 정량화를 위한 개선된 방법Article Published on 2022-05-032022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] aluminum aluminum hydroxide buffer complexity Concentration confirmed cases coronavirus correlation COVID-19 pandemic detect enveloped virus epidemiological data genetic material glycine hydroxide Improved lack matrix mengovirus methodology N1 and N2 organic matter positive Precipitation problems produced quantification quantity reduction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection selected targets virus wastewater [DOI] 10.1038/s41598-022-11187-8 PMC 바로가기 [Article Type] Article
Improved immunologic response to COVID-19 vaccine with prolonged dosing interval in haemodialysis patients혈액투석 환자에서 투여 간격 연장으로 코로나19 백신에 대한 면역 반응 개선Article Published on 2022-05-012022-09-12 Journal: Scandinavian journal of immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 2019 coronavirus disease affecting anti-SARS-CoV-2 anti-SARS-CoV-2 spike protein IgG antibodies antibody Antibody titre antibody titres BNT162b2 Combination coronavirus COVID-19 COVID-19 infection COVID-19 vaccine cross-sectional disease incidence dose doses dosing interval eligible Factor group Haemodialysis IgG IgG test immunologic response Improved Inclusion Increasing median mRNA vaccine mRNA-1273 not differ parameters Patient patients Phadia reduce respiratory syndrome coronavirus response rate SARS-CoV-2 SARS-CoV-2 antibody titre second dose serum calcium severity Spike protein Swedish Thermo Fisher Scientific titre vaccination vaccine dose Vaccines while [DOI] 10.1111/sji.13152 PMC 바로가기 [Article Type] Article