In situ hybridization – Page 2 – Communicable Diseases Research

Histologic, viral, and molecular correlates of heart disease in fatal COVID-19

Research article

Published on 2022-10-012022-10-05
Journal: Annals of diagnostic pathology [Category] COVID19(2023년), SARS, 진단, 치료기술,

Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis

Epipharyngeal Abrasive Therapy(EAT)는 만성 인두염에서 주요 전염증성 사이토카인 IL-6의 mRNA 발현을 감소시킵니다

Article

Published on 2022-08-162022-09-11
Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘,

[키워드] Abrasive addition aggregation Alpha analyzed anti-inflammatory effect Cell chronic chronic fatigue syndrome chronic inflammation contribute cough COVID cytokine cytokine network Cytokines Diseases effective epipharyngeal abrasive therapy (EAT) epipharyngitis epipharynx expression expression pattern fatigue fatigue syndrome Hypothesis IgA IgA nephropathy IL-6 IL-6 expression IMPROVE In situ hybridization induce Inflammatory cytokine Inflammatory cytokines Inflammatory diseases interleukin interleukin 6 interleukin 6 (IL-6) intractable involved Japan Local Long Long COVID Major mechanisms mRNA myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) nasal Nasal cavity Necrosis nephropathy Patient postnasal drip Proinflammatory cytokine reduced reported responsible Sedation significantly lower subject suggested suppressed suppression Symptom syndrome systemic inflammatory disease systemic inflammatory diseases systemic symptoms therapy TNFα treated Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha tumor necrosis factor alpha (TNFα). upper respiratory tract
[DOI] 10.3390/ijms23169205 PMC 바로가기 [Article Type] Article

Cell tropism and viral clearance during SARS-CoV-2 lung infection

SARS-CoV-2 폐 감염 중 세포 친화성 및 바이러스 제거

Article

Published on 2022-08-012022-09-11
Journal: Pathology, research and practice [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

[키워드] Alpha alveolar macrophage Alveolar macrophages autopsy studies B.1.1.529 B.1.1.7 B.1.617.2 capillary microthrombosis caused Cellular target COVID-19 debate Delta detect driving Endothelial cell endothelial cells Endothelialitis epithelial cells fatal COVID-19 high viral load identify In situ hybridization infected cell key factor Lung infection lung tissue macrophages Microthrombosis omicron original virus strain Patient protein-coding RNA pulmonary reported RNA SARS-CoV-2 SARS-COV-2 infection severe COVID-19 spike Spike protein Time-course. variants variants of concern viral clearance viral infection Viral load Viral RNA was used
[DOI] 10.1016/j.prp.2022.154000 PMC 바로가기 [Article Type] Article

Coronavirus disease 2019 and the placenta: A literature review

코로나바이러스 질병 2019 및 태반: 문헌 검토

Review

Published on 2022-08-012022-09-11
Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus
[DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review

Fluorescent Platforms for RNA Chemical Biology Research

RNA 화학 생물학 연구를 위한 형광 플랫폼

Review

Published on 2022-07-272022-09-11
Journal: Genes [Category] 치료제,

[키워드] activities activity applied assays binding Biology Biotin change Chemical Chemical biology Clinical research clinically COVID-19 test COVID-19 tests CRISPR Degradation demonstrated detect Drug discovery drugs targeting Efficacy Efficiency efficient energy transfer ENhance enzyme Enzyme labeling example facilitate fit Fluorescence fluorescence anisotropy Fluorescence imaging fluorescent fluorescent assays. Forced In situ hybridization increase invention lAbel labeling living cells Mango microRNA miRNA movement mRNA ncRNAs non-coding RNA Non-coding RNAs Nuclease observation overcome probe Research ribonucleoprotein RNA ROI subcellular T-box tumors
[DOI] 10.3390/genes13081348 PMC 바로가기 [Article Type] Review

Suppression of Pituitary Hormone Genes in Subjects Who Died From COVID-19 Independently of Virus Detection in the Gland

샘에서 바이러스 검출과 독립적으로 COVID-19로 사망한 피험자의 뇌하수체 호르몬 유전자 억제

Article

Published on 2022-07-142022-09-11
Journal: The Journal of Clinical Endocrinology and Metaboli [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] ACTH adrenocorticotropic adrenocorticotropic hormone Antigen antigens cardiac death Cell Chain Reaction changes in clinically controls COVID-19 COVID-19 case COVID-19 group cytotoxic cell death deficiency detection died direct viral infection dysfunction evaluate exploration expression Gene Expression Genes gland hormone Hormones hospitalized patients hypophysis immune immunohistochemistry In situ hybridization investigated Involvement Level mRNA transcript mRNA transcripts neurohypophysis neutrophil Patient PCR Pituitary pituitary apoplexy pituitary gland pituitary hormone pituitary hormones. polymerase chain polymerase chain reaction Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection searched serum severe COVID-19 Signaling subject sudden cardiac death suggested Support suppressed suppression the SARS-CoV-2 genome transmission electron microscopy trauma tropism tropism of SARS-CoV-2 type I interferon Viral viral genome viral infection virus were measured
[DOI] 10.1210/clinem/dgac312 PMC 바로가기 [Article Type] Article

SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent origin

SARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.

Article

Published on 2022-07-012022-09-11
Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified Analysis approaches assays Autoimmune disease Autoimmune diseases Betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology
[DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article

Histopathology and localization of SARS-CoV-2 and its host cell entry receptor ACE2 in tissues from naturally infected US-farmed mink ( Neovison vison)

Article

Published on 2022-07-012023-07-08
Journal: Veterinary pathology [Category] COVID19(2023년),

[키워드] angiotensin-converting enzyme 2 COVID-19 immunohistochemistry In situ hybridization Minks olfactory marker protein RT-PCR severe acute respiratory syndrome coronavirus 2
[DOI] 10.1177/03009858221079665

SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13

기도 세포의 SARS-CoV-2 감염은 IL-13에 의해 영향을 받는 두 가지 확산 메커니즘인 강력한 바이러스 및 세포 방출을 유발합니다

Article

Published on 2022-04-192022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected airway airways Allergic asthma Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Asthma asthmatic cause caused Cell Cell culture cell cultures cell tropism cells ciliated cell ciliated cells coronavirus COVID-19 COVID-19 severity down-regulated gene down-regulated genes electron microscopy enzyme epithelial epithelial cells examined expression gene expression analyses Gene Expression Omnibus Genes glycoprotein HAE high risk host–virus interaction human airway human airway epithelial human airway epithelial cells IL-13 IL-13 cytokine immunohistochemistry In situ hybridization infected cells Infection interferon interleukin interleukin-13 Intracellular involved keratan sulfate Lung disease mechanism Messenger RNA Microscopy MUC5AC mucin Mucus number of infected primary human airway reduced removal Replication RNA RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shedding shielding significantly Spread sulfate susceptibility Transmission Transport TRAP treated up-regulated viral egress viral entry Viral load Viral reservoir viral spread viral titers virions viruses were infected
[DOI] 10.1073/pnas.2119680119 PMC 바로가기 [Article Type] Article

Activation of STAT3 signaling pathway in the kidney of COVID-19 patients

코로나19 환자의 신장에서 STAT3 신호전달 경로 활성화

Observational Study

Published on 2022-04-012022-09-11
Journal: Journal of Nephrology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술,

[키워드] ACE2 expression activated Acute kidney injury AKI Autopsy cells COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines detect died disease electron microscopy glomerular glomerular disease glomerulosclerosis immunofluorescence immunostaining In situ hybridization Injury investigated kidney Kidney injury light microscopy mechanism Microscopy mononuclear cell mononuclear cells Mount Sinai NF-kB observational study pandemic Pathologists pathology Patient patients with COVID-19 performed peritubular capillary Phosphorylation renal Renal pathology. SARS-CoV-2 Serine signaling pathway significant increase STAT3 TMPRSS2 transcription factor transcription factors tubular cell tubular cells two patients tyrosine was increased was reduced with COVID-19
[DOI] 10.1007/s40620-021-01173-0 PMC 바로가기 [Article Type] Observational Study