Real-World Evidence for COVID-19 Delta Variant’s Effects on the Digestive System and Protection of Inactivated Vaccines from a Medical Center in Yangzhou, China: A Retrospective Observational StudyObservational Study Published on 2022-08-192022-10-04 Journal: International journal of clinical practice [Category] SARS, 바이오마커, 변종, 임상, [키워드] addition Affect alanine aminotransferase ALT analysis of variance ANOVA AST Bilirubin biochemical center changes in Chinese Cohort Coronavirus disease 2019 COVID-19 Critical Critical disease Delta delta variant diagnosed digestive system dysfunction early stage Effect evaluate function Gastrointestinal symptom global public health IL-6 level Inactivated vaccine inactive Infection interleukin 6 (IL-6 investigated lactate dehydrogenase LDH liver dysfunction marker mild illness moderate no significant difference p value Patient prevalent Prevent promoted PROTECT protection public health reported respiratory tract retrospective serum severity Significant significant difference significantly more Sinopharm Sinovac statistically significant Symptom System three group three groups total bilirubin Treatment Vaccine variant was used [DOI] 10.1155/2022/7405448 PMC 바로가기 [Article Type] Observational Study
Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trialClinical Trial Published on 2022-08-102022-10-06 Journal: The Lancet. Infectious Diseases [Category] SARS, 변종, 진단, [키워드] 1:1 Administered administration adverse event adverse events age amplifying analysed Analysis antibody concentration Antigen assigned available data BMI booster booster dose Breastfeeding Coalition Contraception COVID-19 pandemic diagnosis of COVID-19 dose Efficacy enrolled evaluated event Evidence exclusion geometric mean titre GMT group healthy homologous IgG immune response inactive increase in initial intramuscular Local Matrix-M median Medical conditions Novavax NVX-CoV2373 outcome participant per-protocol per-protocol population phase 2 trial phase 3 study Placebo placebo-controlled pregnant primary endpoint proportion Protein randomisation randomised Randomly reaction reactogenicity receive Recombinant spike protein recruited regimens Registered Safety SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant screened serum IgG single booster dose stratified Support the SARS-CoV-2 the vaccine titres Treatment Trial USA vaccination Vaccine variant were excluded women [DOI] 10.1016/S1473-3099(22)00420-0 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 specific antibody responses in healthcare workers after a third booster dose of CoronaVac or BNT162b2 vaccineCoronaVac 또는 BNT162b2 백신의 3차 추가 접종 후 의료 종사자의 SARS-CoV-2 특이 항체 반응Article Published on 2022-08-012022-09-12 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, [키워드] adverse event Antibody Response Antibody titer BNT162b2 BNT162b2 vaccine booster dose chose CoronaVac Day eligible evaluate female HCW HCWs healthcare worker humoral Immunoglobulin Immunoglobulin G inactive individual male marker median Ministry of Health mRNA vaccine participant reported SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-CoV-2 vaccination serum significant difference Sinovac the S1 subunit the spike protein Turkey vaccination Vaccine virus were given [DOI] 10.1002/jmv.27794 PMC 바로가기 [Article Type] Article
Anxiety is more related to inadequate eating habits in inactive than in physically active adults during COVID-19 quarantineResearch article Published on 2022-08-012022-10-05 Journal: Clinical nutrition ESPEN [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI adjusted age Anxiety association body mass index COVID-19 COVID-19 pandemic Depression eating habits exercise Final food Health inactive individual less Logistic regression media mental health Motor behavior Pandemics participant Participants physical activity physically quarantine question questionnaire reduced Result Sex social isolation Stress sweet was related were assessed women [DOI] 10.1016/j.clnesp.2022.08.010 [Article Type] Research article
Effects of Structured Supervised Exercise Training or Motivational Counseling on Pregnant Women’s Physical Activity Level: FitMum – Randomized Controlled TrialRandomized Controlled Trial Published on 2022-07-202022-10-04 Journal: Journal of Medical Internet Research [Category] 임상, [키워드] 95% CI activity addition adjusted Adverse age Analysis association Attendance average baseline Changing commercial activity tracker complementary Compliance Controlled counseling COVID-19 Digital health doubly labeled water Effect effective evaluate the effect event EXE exercise fitness Garmin gold standard groups Health health outcome healthy hypothese IMPROVE inactive intensity Intervention intervention group investigated IQR Maternal Maternal Health maternity measure median motivation not affect not differ Offering participant performed physical physical activity physical activity questionnaire pregnancies Pregnancy pregnant pregnant women Primary outcome primary outcome analysis randomization Randomized Randomized controlled trial RCT recommendation Registered Safe Serious Adverse Event standard care tracker training was measured was performed women women's health would increase [DOI] 10.2196/37699 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2뉴클레오사이드/뉴클레오타이드 유사체 테노포비르와 엠트리시타빈은 SARS-CoV-2에 대해 비활성입니다Article Published on 2022-06-302022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerated active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity antiviral agent Antiviral agents Antiviral effect approaches approved approved drug biochemical causative pathogen caution Cell clinicians and researcher Concentration coronavirus COVID-19 COVID-19 pandemic demonstrated Efficiency emtricitabine epithelial FTC HIV-1 HIV-1 NRTI human lung in vitro data inactive indicate inhibitor lack metabolite NHBE NTP nucleoside polymerase Prevent RdRP RdRp active site required reverse transcriptase RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus TAF TDF tenofovir Tenofovir alafenamide the SARS-CoV-2 transcriptase treat unlikely [DOI] 10.3390/molecules27134212 PMC 바로가기 [Article Type] Article
Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system원핵생물 발현 시스템에서 기능적으로 활성인 재조합 SARS-CoV-2(COVID-19) 3C 유사 프로테아제 및 가용성 불활성 3C 유사 프로테아제-RBD 키메라의 생산Article Published on 2022-06-202022-09-11 Journal: Epidemiology and Infection [Category] COVID19(2023년), SARS, 치료제, [키워드] 3C-like protease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antigenicity approach blocked carrier cells Chimer chimeric chymotrypsin co-expressed complex coronavirus COVID-19 COVID-19 vaccines cysteine cysteine protease cysteine proteases dimeric disease drug ELISAs enzyme Escherichia coli Escherichia coli BL21 exhibit expression function inactive inhibitors inhibitory main protease non-structural protein non-structural proteins Papain Papain-like protease PLPro polyproteins pp1a pp1ab processing produced Production prokaryotic expression system protease Proteases Protein purification RBD Receptor binding domain RTC SARS-CoV-2 Serine serum severe acute respiratory syndrome Coronavirus solubility Spike protein target tested the Spike Transcription vaccinated individual vaccinated individuals viral replication [DOI] 10.1017/S0950268822001078 PMC 바로가기 [Article Type] Article
Impact of Physical Activity Differences Due to COVID-19 Pandemic Lockdown on Non-Alcoholic Fatty Liver Parameters in Adults with Metabolic Syndrome대사 증후군이 있는 성인의 비알코올성 지방간 매개변수에 대한 COVID-19 유행성 폐쇄로 인한 신체 활동 차이의 영향Article Published on 2022-06-082022-09-11 Journal: Nutrients [Category] 임상, [키워드] activity affected Analysis blood collection Characteristics cholesterol COVID-19 COVID-19 lockdown COVID-19 pandemic decrease difference disease Efficiency Fatty liver fatty liver disease fitness functional group groups HDL-cholesterol healthy Impact IMPROVE inactive intensity lockdown longitudinal magnetic resonance imaging Mediterranean diet Mediterranean lifestyle medium metabolic metabolic syndrome moderate motivation MRI NAFLD Non-alcoholic fatty liver disease parallel-group parameter participant Patient per day physical activity progression questionnaire randomized trial Stopping syndrome were assessed worsening [DOI] 10.3390/nu14122370 PMC 바로가기 [Article Type] Article
Train at home, but not alone: a randomised controlled multicentre trial assessing the effects of live-streamed tele-exercise during COVID-19-related lockdownsRandomized Controlled Trial Published on 2022-06-012022-10-04 Journal: British journal of sports medicine [Category] 임상, [키워드] 95% CI activity addition Analysis Anxiety applied both group caused chronic control group country COVID-19 COVID-19 pandemic decrease Effect ENhance exercise Factors female Generalized GRADE Health healthy individual implementation inactive Intervention investigated lockdown lockdowns marker mean difference Mental moderate multicentre nine physical activity Preventive medicine Public randomised controlled randomised controlled trial reduce reductions in Research scale selected Sleep sleep quality Trial was performed Well-being were used [DOI] 10.1136/bjsports-2021-104994 PMC 바로가기 [Article Type] Randomized Controlled Trial
Longitudinal profile of neutralizing and binding antibodies in vaccinated and convalescent COVID-19 cohorts by chemiluminescent immunoassays화학발광 면역분석에 의한 백신 접종 및 회복기 COVID-19 코호트에서 중화 및 결합 항체의 종단 프로필Article Published on 2022-06-012022-09-11 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] antibodies antibody antibody profile, COVID-19 convalescent Antibody testing binding antibody booster vaccination chemiluminescent immunoassay coefficient coefficient of correlation convalescent correlation COVID-19 COVID-19 cohort diagnostic dose elicited enrolled enzyme evaluate evaluated exhibited extension humoral immune response Humoral immunity IgG Immune status Immunity immunoassay Immunoglobulin Immunoglobulin G inactive Infection Interpretation longitudinal Neutralizing neutralizing antibody no difference priming priming dose Protective RBD RBD IgG referred to risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD SARS-CoV-2 vaccine seroconversion rate serological Serological assay serum surrogate the SARS-CoV-2 therapy threshold trajectory vaccination vaccination schedule Vaccine Volunteer was collected [DOI] 10.1002/iid3.612 PMC 바로가기 [Article Type] Article