increased expression – Page 2 – Communicable Diseases Research

Whole-genome sequencing reveals host factors underlying critical COVID-19

전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다

Article

Published on 2022-07-012022-09-11
Journal: Nature
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제,

Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing

단일 세포 RNA 시퀀싱으로 밝혀진 COVID-19 회복기 개인의 면역 기능

Article

Published on 2022-07-012022-09-11
Journal: International immunopharmacology
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Activation addition B cell B cell subset B cells Bioinformatics analysis biological processe biological processes CD4 CD8 Cell cell receptor cell-cell adhesion clonal expansions Cluster convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent individual convalescent individuals convalescent patient Convalescent patients COVID-19 Critical declined decreased expression differentiation downregulation effector memory feature function functions GNLY HLA class I HLA class II HLA class II genes humoral immune response Humoral immunity immune protection immune response immune responses increased expression infections Innate innate immune responses Innate immunity Interferon-gamma involved leukocyte mapped marginal zone mechanism Migration moderate natural infection neutrophil Peripheral blood peripheral blood samples phenotypic reflected Regulation Reinfection retained RNA SARS-CoV-2 SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses severe cases single cell RNA sequencing Single-cell RNA sequencing subjects subset sustained T cell T cell activation T cell response T/B cell receptor repertoire. TCR upregulation was increased weakened with COVID-19 zone
[DOI] 10.1016/j.intimp.2022.108767 PMC 바로가기 [Article Type] Article

Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations

폐 내피 세포의 단일 세포 전사체 프로파일링은 동적 염증 및 재생 하위 집단을 식별합니다

Article

Published on 2022-06-082022-09-11
Journal: JCI Insight
[Category] COVID19(2023년), SARS, 신종인플루엔자, 유전자 메커니즘,

[키워드] Activation Bacterial infections baseline Cell Clustering defined demonstrated division endothelial endothelial cells Endothelium expression Gene Expression H1N1 H1N1 influenza H1N1 influenza virus heterogeneity identify immune response gene immune response genes increased expression infected with SARS-CoV-2 Infectious disease Inflammatory inflammatory lung injury inflammatory signaling Influenza Injury labor limit LPS lung lung endothelial Lung injury MHC gene MHC genes murine organ overexpression Pathway analysis performed phenotypic prevented proliferative promote Pulmonology Pulmonology. regeneration regenerative respond Seurat single-cell single-cell RNA-seq Sox17 subpopulation targeted therapy transcriptomic Vascular vascular bed vascular endothelial cell vascular endothelial cells virus
[DOI] 10.1172/jci.insight.158079 PMC 바로가기 [Article Type] Article

Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

치주염은 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 프라이밍 프로테아제인 치은 막횡단 세린 프로테아제 2(TMPRSS2)의 발현을 촉진합니다

Article

Published on 2022-06-012022-09-11
Journal: Journal of oral biosciences
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome Analysis analyzed anti-TMPRSS2 antibody cell membrane ChIP coronavirus correlation COVID-19 dataset datasets ESR1 Estrogen estrogen receptor Express expressed expression Gene Expression Gene Expression Omnibus GEO GEO dataset Gingiva Human increase increased expression investigated keratinocytes Ligand oral cavity Periodontitis priming promote promoter promoter region protease Quantitative responsible reverse transcription SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2. screened Serine Spike protein the SARS-CoV-2 tissue tissues TMPRSS2 TMPRSS2 expression transcription factor transcription factors transmembrane serine protease transmembrane serine protease 2 was performed western blot Western blot analysis
[DOI] 10.1016/j.job.2022.04.004 PMC 바로가기 [Article Type] Article

Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages

단핵구 및 대식세포의 케모카인 수용체 유전자 조절과 관련된 심각한 COVID-19 관련 변이체

Article

Published on 2022-04-142022-09-11
Journal: Genome Biology
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19

PathogenTrack 및 Yeskit: COVID-19에 적용하여 설명된 단일 세포 RNA 시퀀싱 데이터 세트에서 세포내 병원체를 식별하기 위한 도구

Article

Published on 2022-04-012022-09-11
Journal: Frontiers of medicine
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] addition Analysis Antigen Bacteria bacterium BALF Bronchoalveolar lavage fluid cancers cell type cellular cellular distribution Co-infection COVID-19 COVID-19 patient COVID-19 patients database dataset dysfunction epithelial cell epithelial cells feature fungi Github Haemophilus host cell host cells identify immune response in some increased expression induce Infectious disease interferon pathway intracellular pathogen introduced Macrophage macrophages microbe neutrophil other disease other diseases pathogen Pathogens pathway presenting R package raw data robustness SARS-CoV-2 SARS-CoV-2 virus scRNA-seq scRNA-seq data scRNA-seq datasets scRNA-seq. Severe case single-cell level Single-cell RNA-sequencing SRA Still Taking tested the SARS-CoV-2 virus transcriptomic type I interferon type I interferon pathway viruses
[DOI] 10.1007/s11684-021-0915-9 PMC 바로가기 [Article Type] Article

ACE2 protein expression in lung tissues of severe COVID-19 infection

중증 코비드 -19 감염의 폐 조직에서의 ACE2 단백질 발현

Article

Published on 2022-03-082022-09-01
Journal: Scientific Reports
[Category] MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] ACE2 ACE2 expression ACE2 protein acute lung injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen Biomarkers bronchopneumonia CD163 cells Complication controls Coronavirus-2 Correlation analysis COVID-19 COVID-19 disease DAD died Diffuse alveolar damage disease severity Diseases enzyme expression Histomorphology host protein Hypothesis hypothesised IHC immunohistochemistry immunostaining increased expression increased risk indications lung Lung injury lung tissue Macrophage Macrophage infiltration macrophages Medical research microthrombi Molecular biology non-COVID-19 patient Non-COVID-19 patients Pathogenesis Patient performed Platelet positively correlated post-mortem lung Protein protein expression random respiratory Risk factors Sample size SARS-CoV-2 SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection Severe infection significantly higher subset tested tissue Viral Virus Disease was performed were used
[DOI] 10.1038/s41598-022-07918-6 PMC 바로가기 [Article Type] Article

Potential “Therapeutic” Effects of Tocotrienol-Rich Fraction (TRF) and Carotene “Against” Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling Pathways

Article

Published on 2022-03-052022-10-31
Journal: Nutrients
[Category] COVID-19, MERS, SARS,

[키워드] administration alteration Anti-inflammatory antioxidant Apoptosis approach Bacterial biochemical BLM candidate carotene caused collagen Combination demonstrated develop disease downregulated downregulation drug Effect expressions Factors fibrosis fraction functions genetics histopathological histopathological finding hydroxyproline increased expression Inflammatory cytokine influences inhibit injection interstitial investigated Lung fibrosis Lung injury lung tissues management modulation molecular NF-κB NF-κB signaling Pathways post-COVID-19 patient Potential preventive effects Probability proinflammatory cytokines provided pulmonary pulmonary fibrosis rapid progress RAT reduction in reported shown significantly tocotrienol-rich fraction treated Treatment TRF upregulation variety viral infections
[DOI] 10.3390/nu14051094 PMC 바로가기 [Article Type] Article

Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors

COVID-19 및 가와사키병의 타고난 면역 반응 분석은 MIS-C 예측 인자를 밝힙니다

Article

Published on 2022-03-012022-09-11
Journal: Journal of the Formosan Medical Association = Taiw
[Category] SARS, 변종, 치료기술,

[키워드] acute SARS-CoV-2 infection Adults analyses Analysis ArrayExpress association Blood blood cell Blood cells CASP1 CD14 CD36 children Cohort correlated COVID-19 COVID-19 diagnosis COVID-19 severity dataset determine disease downloaded dysregulated dysregulation enriched pathway enriched pathways expression level FCGR2A gene expression signature genetic polymorphisms HLA-DOB IFI16 IFNAR1 immune dysregulation immune response immune responses increased expression Inflammatory Innate innate immune innate immune gene innate immune genes innate immune response Innate immunity Interaction interactions irak4 IRF3 Kawasaki disease MIS-C moderate multisystem inflammatory syndrome. network network analysis NLRP3 pathway Patient PELI1 polymorphism predict predictor predisposition Pycard reveal SARS-CoV-2 infections severe COVID-19 severity STAT3 STING susceptibility syndrome TLR2 TLR7 TLR8 Transcriptome transcriptome datasets transcriptomes variant variants was used with COVID-19
[DOI] 10.1016/j.jfma.2021.06.009 PMC 바로가기 [Article Type] Article

Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations

인도 인구 중 COVID-19 사례 사망률과 TMPRSS2 rs2070788 다형성의 유전적 연관성

Article

Published on 2022-03-012022-09-11
Journal: Infection, genetics and evolution : journal of mol
[Category] SARS, 바이오마커, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 gene ACE2 receptor Analysis analyzed antagonistic approach Asia Asians association Biomarker Case fatality rate causative agent CFR COVID-19 COVID-19 infection COVID-19 susceptibility disease disease susceptibility disparity East engage eQTL analysis expression Fatality rate Frequency G allele Genetic genetic association Genotype Haplotype help Host host cell increased expression India individual information intensity linkage Linkage disequilibrium lung Next-generation sequencing NGS observation pandemic pathogenicity Phylogenetic polymorphism Population populations positive predict priming risk rs2070788. S protein SARS-CoV-2 Serine serine protease severity significantly higher SNP South South Asian susceptibility tested the SARS-CoV-2 TMPRSS2 variant Variation West with COVID-19
[DOI] 10.1016/j.meegid.2022.105206 PMC 바로가기 [Article Type] Article