Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor시험관 내 및 생체 내에서 SARS-CoV-2 감염에 대한 선택적 에스트로겐 수용체 조절제의 항바이러스 효능은 진입 억제제로서 바제독시펜 아세테이트를 나타냅니다Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] Acetate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiviral efficacy Bazedoxifene bazedoxifene acetate candidate cholesterol cholesterol distribution citrate clinical Clomifene Clomifene citrate contagious coronavirus Coronaviruses Critical delta variant distribution drugs Effect Efficacy endosome acidification Estrogen estrogen receptor evaluated exhibited expression hamster hamsters human cell lines humans identify in vitro in vivo infect Infection information inhibited inhibitor interleukin-6 offer omicron Omicron variant pathogenic variant penetration Postinfection pseudovirus pseudoviruses pulmonary viral reduced reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection selective selective estrogen receptor modulator severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2. Tamoxifen toremifene toremifene citrate variant Vero E6 Vero E6 cell VERO E6 cells weight loss [DOI] 10.1002/jmv.27951 PMC 바로가기 [Article Type] Article
Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 네이티브, 엔지니어링 및 드노보 디자인 리간드Review Published on 2022-10-012022-09-12 Journal: Biotechnology advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome affinity Affinity ligands antibody binding Cell concerning Contact coronavirus coronavirus disease de novo de novo design. develop diagnostic diagnostics hACE2 Host human Angiotensin-converting enzyme in vivo infect Interaction lesson Ligand ligands molecular Native natural pandemic Pandemics Patient Prophylactic Protein public health receptor reported responsible S-protein SARS-CoV-2 SARS-CoV-2 proteins Scientific community spike Spike protein the SARS-CoV-2 therapeutic therapy Vaccine virus yielding [DOI] 10.1016/j.biotechadv.2022.107986 PMC 바로가기 [Article Type] Review
Temperature Influences the Interaction between SARS-CoV-2 Spike from Omicron Subvariants and Human ACE2Article Published on 2022-09-302022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] ACE2 ACE2 affinity ACE2 receptor Affect arising BA.4 BA.5 COVID-19 domain enzyme glycoprotein Human immunogenic include infect influence Interaction multiple mutation mutated omicron other variants plasma RBD receptor SARS-CoV-2 shown significantly increased spike spike glycoprotein temperature the Spike translate Transmission vaccinated individuals variant Variant of concern. Viral transmission VoC [DOI] 10.3390/v14102178 PMC 바로가기
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent mannerArticle Published on 2022-09-292022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] ACE2 adipose Adiposity anatomical Cell cell death cells cellular response Disease progression Express expression fat fat cell infect Infection Lineage occur pro-inflammatory cytokines risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility susceptible the SARS-CoV-2 tissue variant viability visceral [DOI] 10.1038/s41467-022-33218-8 PMC 바로가기
SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expressionArticle Published on 2022-09-232022-11-16 Journal: Science Advances [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome blood vessels CLDN5 coronavirus coronavirus disease COVID-19 disrupt disrupting down-regulation endothelial epithelial cell expression fluvastatin infect initial investigated junctions lung mechanism organ other organ overexpression patient with COVID-19 produced Protein protein expression rescued respiratory epithelial cell SARS-CoV-2 therapeutic strategy transfer Treatment Vascular [DOI] 10.1126/sciadv.abo6783 PMC 바로가기
An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccinesArticle Published on 2022-09-222022-11-15 Journal: PLoS Pathogens [Category] SARS, 진단, [키워드] acute respiratory syndrome Asia bat bats Cell cell entry circulating COVID-19 pandemic Cross reactivity engage facilitate Health host cell Human human ACE2 human cells human pathogen identify individual infect Invasion Lineage majority monoclonal antibody outbreak pseudotype RBD receptor Receptor binding domain sarbecovirus SARS-CoV SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine serological serum tested the RBD Vaccine virus virus while [DOI] 10.1371/journal.ppat.1010828 PMC 바로가기
Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virionsArticle Published on 2022-09-192022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] 6-Thioguanine ACE2-expressing cells acting antiviral activity antiviral drug antivirals approach betacoronavirus betacoronaviruses biochemical Cell complementary coronavirus demonstrated early stage ectopic expression Effect full-length Genetic GTPase had no HCoV-OC43 HPRT1 in vitro infect Infection inhibit inhibitor lentivirus nucleotide oligosaccharide outcome progeny virion Protein pseudotyped pseudovirus Replication SARS-CoV-2 selective shown spike structural proteins subgenomic RNA target Treatment Viral diseases viral genomes Virus-like particle VLPs yielding [DOI] 10.1371/journal.ppat.1010832 PMC 바로가기
SARS-CoV-2 can infect human embryosArticle Published on 2022-09-142022-11-15 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] ACE2 antibody canonical Cell cell entry cells co-expressed COVID-19 COVID-19 pandemic Effect Embryo embryogenesis embryos Factor fluorescent glycoprotein Health human tissue identify immunofluorescence implicated implication infect Infection observé organ pandemic Pregnancy reporter reproductive resulting RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection spike Spread susceptibility susceptible Symptom target tissue TMPRSS2 viral entry virions pseudotyped [DOI] 10.1038/s41598-022-18906-1 PMC 바로가기
SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy PathogenesisArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 acute respiratory distress alveolar angiotensin-converting enzyme 2 binding blocked Blood coagulation Capillaries cell types cellular co-culture Coagulopathy communication Contact COVID-19 COVID-19 patient Delta Disease progression drug DTNB endothelial Endothelial cell endotheliopathy Evidence Express expression extrinsic pathway Factor Factor-V fibrinogen functional groups had no Human human lung human lung endothelial cells humans induce infect inhibited inhibitor interactions investigated leukocyte mechanism Microvascular thrombosis neutrophil Neutrophils Pathogenesis pathway Patient potential mechanisms prevented Protein pulmonary complication Pulmonary endothelium recombinant S-protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 variant SARS-CoV-2 virion secretion severe lung injury significantly increased spike syndrome target cell TFPI therapeutic strategy thrombin thrombomodulin thrombosis tissue Tissue factor. Transcriptional upregulation vascular endothelial cell vessel Wuhan [DOI] 10.3390/ijms231810436 PMC 바로가기
Susceptibility of Domestic Goat ( Capra aegagrus hircus) to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.351/Beta VariantArticle Published on 2022-09-092022-11-16 Journal: Viruses [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 Beta Beta variant classical coronavirus coronavirus 2 demonstrated distribution ELISA Evidence Experimental infection goat immunohistochemistry in silico Approach infect Infection Live virus nasal swab natural neutralisation assays performed predict reported respiratory RT-qPCR ruminant SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility Susceptibility. susceptible the receptor-binding domain the spike protein tissue unlikely variant Viral variants was used wild animals [DOI] 10.3390/v14092002 PMC 바로가기