Anakinra after treatment with corticosteroids alone or with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammation. A retrospective cohort study중증 COVID-19 폐렴 및 중등도 과염증 환자에서 코르티코스테로이드 단독 또는 토실리주맙 치료 후 아나킨라. 후향적 코호트 연구Observational Study Published on 2021-06-012022-09-12 Journal: Internal and Emergency Medicine [Category] MERS, 임상, 진단, [키워드] 95% CI according to protocol adjusted hazard ratio Admission age Anakinra analyzed appear carried CD4 Characteristics clinical Clinical course Clinical severity Corticosteroid corticosteroid pulse COVID-19 Cytokine storm syndrome death died Evidence hyperinflammation hyperinflammatory state IMPROVE infectious complication Infectious complications intensive care Laboratory management Methylprednisolone moderate Mortality Observational cohort study Patient patients with moderate Prognosis pulse receiving receptor reduced risk retrospective retrospective cohort study Severe COVID-19 pneumonia Standard therapy Tocilizumab tocilizumab therapy Treatment treatment with anakinra [DOI] 10.1007/s11739-020-02600-z PMC 바로가기 [Article Type] Observational Study
Hypoalbuminemia as Surrogate and Culprit of InfectionsReview Published on 2021-04-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acquisition acute lung injury Adaptive immune response Affect albumin albumin level albumins/pharmacology Antimicrobial therapy Antimicrobials Bacteremia Bacterial bioactive lipid mediators causal link changes in chronic conditions cirrhosis Clinical practice Clostridium difficile community-acquired pneumonia Complication coronavirus disease Defense Diseases Effect evidence of fungal infections Healthcare-associated infection Hypoalbuminemia hypothese in viral increased risk Infection infections infectious complication Infectious complications infusion Innate immunity Interaction lipid mediator liver management organ dysfunction Patient predict Prognostic value Prospective Randomized controlled trial RCT RCTs risk secondary infections Sepsis serum albumin severity supported surrogate Treatment Viral load [DOI] 10.3390/ijms22094496 PMC 바로가기 [Article Type] Review
Obesity, Nutrients and the Immune System in the Era of COVID-19Review Published on 2021-02-132022-10-31 Journal: Nutrients [Category] COVID-19, MERS, [키워드] acute respiratory distress addition adipocyte adipocytes adipose Affect alteration Apoptosis cardiovascular complications caused characteristic chronic disease circulation complications Compound COVID-19 cytokine Cytokines death decrease disrupting Disseminated intravascular coagulation Effects element endothelial Endothelial dysfunction Endotheliitis excess Excessive activation fat Fat mass forms function hypercoagulability hypertrophic Immune cell immune cells immune system increase increase in induce Infection infection-related mortality Infectious complications infiltration Inflammasome Inflammation inflammatory state insulin resistance Leptin Lipid Lymphoid Organ Macrophage multiple organ failure NLRP3 inflammasome nutrient obese obesity pro-inflammatory promote recruitment released responsible risk risk factor risk of infection SARS-COV-2 infection saturated secondary bacterial infection severe complication severe COVID-19 Severe infection Shock shown subjects sugar susceptibility syndrome System systemic inflammatory These cells tissue [DOI] 10.3390/nu13020610 PMC 바로가기 [Article Type] Review
Impact of coronavirus disease 2019 (COVID-19) outbreak on outcome of myocardial infarction in Hong Kong, ChinaObservational Study Published on 2021-02-012022-10-05 Journal: Catheterization and cardiovascular interventions : official journal of the [Category] 임상, [키워드] ACS/NSTEMI acute myocardial infarction/STEMI Affect Analysis Care China communicable Community Contact coronavirus disease Course COVID-19 COVID-19 outbreak COVID-19 pandemic cross-sectional determine Diagnosis disease emergency response Health health care outcomes. healthcare Healthcare system Hong Kong hospital human behavior Impact In-hospital In-hospital death Infectious complications Infectious disease measure Myocardial Myocardial infarction outbreak outcome outcomes Patient reduction in resource Shock significantly single center Stress Support sustained Tachycardia Treatment ventricular [DOI] 10.1002/ccd.28943 PMC 바로가기 [Article Type] Observational Study
Anti-IL6 treatment of serious COVID-19 disease A monocentric retrospective experience심각한 COVID-19 질병의 항IL6 치료 단일 중심적 후향적 경험4900 Published on 2021-01-082022-09-12 Journal: Medicine [Category] 진단, [키워드] acting Acute myocardial infarction acute respiratory distress acute respiratory distress syndrome anti-cytokine anti-IL6 ARDS candidate Candidates clinical trial collected data Complication complications control group coronavirus counterproductive COVID-19 COVID-19 pneumonia cytokine determine died discharged disease drug effective eligible event form framework help Hospitalization Hospitalized identify IL6 Infectious complications Inflammation intensive care interleukin-6 Intervention intravenously Intubated lower mortality medium Mortality multi-organ failure Patient Pneumonia Prognosis Pulmonary thromboembolism reducing respiratory complication Respiratory complications respiratory distress Respiratory failure retrospective risk sarilumab serious COVID-19 severe acute respiratory distress syndrome severe respiratory failure single center Standard of care suffered syndrome systemic level Therapies Thromboembolism Tocilizumab treated Treatment [DOI] 10.1097/MD.0000000000023582 PMC 바로가기 [Article Type] 4900
Effects of Tocilizumab in COVID-19 patients: a cohort studyCOVID-19 환자에서 Tocilizumab의 효과: 코호트 연구Observational Study Published on 2020-12-222022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 임상, 진단, [키워드] Administered black Clinical improvement cohort study Complication conducted coronavirus COVID-19 CRP cytokine Cytokine release syndrome Cytokine storm demonstrated died discharged dose early administration early treatment Effect evaluated help Hispanic hospital Hospital admission Hospitalized Hyperinflammatory Hyperinflammatory response IL-6 IL-6 receptor Infectious complications initial initial symptom initial symptoms intravenous tocilizumab lack male median median age mitigate Most patient Most patients observational study occurred PaO Patient progressive respiratory failure randomized controlled study receiving reduction in remained Respiratory failure Result retrospective SARS-CoV-2 slight increase subsequent supplementary material sustained Therapies Tocilizumab [DOI] 10.1186/s12879-020-05701-4 PMC 바로가기 [Article Type] Observational Study
Impact of COVID-19 pandemic on patient satisfaction and surgical outcomes: A retrospective and cross sectional studyOriginal Research Published on 2020-08-212022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] Admission affected Complication complications conducted COVID-19 COVID-19 pandemic cross discharge domains evaluate female Health care system hospital ICU Impact indicate Infectious complications Khalid King measure Measures median Nurse objective oncology outcome outcome measures outcomes pandemic parameter participant Patient Patient care Patient satisfaction Patient's satisfaction patients patients died positive patient postoperative provided reported required Result retrospective Retrospective cross-sectional study Safe Satisfaction Saudi Arabia selective Surgeries surgical Surgical Procedure sustained the patient treated university [DOI] 10.1016/j.amsu.2020.08.020 PMC 바로가기 [Article Type] Original Research
Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern ItalyCommunication Published on 2020-06-302022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] acute respiratory distress Administered calcineurin calcineurin inhibitors Clinical course CNI cohort of patient cohort study collected Comorbidities consecutive patient Course COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients diarrhea died disease disorder evaluate evaluated Fever generally mild hospital Hospitalized Immunosuppression Infectious complications inhibitor inhibitors IQR Italy males median age North outcome Patient presenting Result Rheumatic diseases risk solid organ transplantation syndrome therapy Treatment [DOI] 10.3390/microorganisms8070977 PMC 바로가기 [Article Type] Communication
Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantationArticle Published on 2017-07-012023-06-02 Journal: Vox Sanguinis [Category] 두창, [키워드] allogeneic hematopoietic stem cell transplantation fascia Infectious complications stem cell products transferred immunity. [DOI] 10.1111/vox.12521 PMC 바로가기
Risk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase InhibitorsReview Published on 2015-04-212024-09-04 Journal: Biomarker Insights [Category] 대상포진, [키워드] BCR signaling BCR-ABL BRAF EGFR infections Infectious complications Jak kinase inhibitors mTOR targeted therapy TKI VEGF [DOI] 10.4137/BMI.S22430 PMC 바로가기 [Article Type] Review