Safety and immunogenicity of the measles vector-based SARS-CoV-2 vaccine candidate, V591, in adults: results from a phase 1/2 randomised, double-blind, placebo-controlled, dose-ranging trial성인에서 홍역 벡터 기반 SARS-CoV-2 백신 후보 V591의 안전성 및 면역원성: 1/2상 무작위, 이중 맹검, 위약 대조, 용량 범위 시험 결과Clinical Trial Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] SARS, 임상, 치료기술, [키워드] Adverse adverse events anti-SARS-CoV-2 assigned convalescent serum COVID-19 COVID-19 disease Culture Day death dose double-blind event fatigue headache healthy humoral immunogenicity immunogenicity Inc. infectious dose injection Injection-site pain Intramuscular injection median multicentre myalgia neutralising antibody occurred Older participant Placebo placebo-controlled randomised response Safety SARS-CoV-2 SARS-CoV-2 vaccine screened secondary secondary outcome Serious Adverse Event Serious Adverse Events serum Sharp single dose subsidiary TCID tissue tissue culture titre titres Trial USA Vaccine [DOI] 10.1016/j.ebiom.2021.103811 PMC 바로가기 [Article Type] Clinical Trial
Enhanced apoptosis as a possible mechanism to self-limit SARS-CoV-2 replication in porcine primary respiratory epithelial cells in contrast to human cellsArticle Published on 2021-12-102022-10-31 Journal: Cell Death Discovery [Category] COVID-19, [키워드] ACE2 expression Activation Analysis Apoptosis apoptotic caspase Cell Clinical sign COVID-19 dose-dependent dose-dependent manner enhanced ferrets former hallmark hamsters Health HREC human cell humans Immune cell death in vivo infect Infection infectious dose investigated less mechanism Microbiology Morphological replicated reported respiratory epithelial cell respiratory epithelial cells SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 replication Seroconversion susceptibility susceptible therapeutic Transmission Treatment viral shedding virus [DOI] 10.1038/s41420-021-00781-w PMC 바로가기 [Article Type] Article
An upper bound on one-to-one exposure to infectious human respiratory particles405 Published on 2021-12-022022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] acute respiratory syndrome affected airways ambient calculate Community coronavirus COVID-19 database disease transmission effective Effectiveness Evidence Face mask individuals infection risk infectious dose less Mask near-field model Particle provide reduce reducing risk risk of infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 viral load Significance significantly social distancing surgical susceptible Transmission wearing [DOI] 10.1073/pnas.2110117118 PMC 바로가기 [Article Type] 405
SARS-CoV-2 and the role of orofecal transmission: a systematic reviewSARS-CoV-2와 구강내 전파의 역할: 체계적인 검토Systematic Review Published on 2021-11-022022-09-11 Journal: F1000Research [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] addition articles average Case series case sery China Cohort cohort study Contact content COVID-19 COVID-19 diagnosis COVID-19 patients criteria Culture demonstrated Diagnosis Dynamics epithelial cells Evidence fecal fecal samples feces FIVE gastrointestinal disease gastrointestinal tract Google Google Scholar include individuals with COVID-19 infect infectious dose Infectious virus intestinal epithelial cells Invasion medRxiv mode observational studies observational study open Orofecal patients positive public health Quantitative data recorded reported respiratory respiratory sample Respiratory samples review RT-PCR SARS-CoV-2 SARS-CoV-2 RNA Symptom systematic review tested Transmission Transmission dynamics transmission of SARS-CoV-2 transmitted Viral viral culture virus wastewater water WHO [DOI] 10.12688/f1000research.51592.2 PMC 바로가기 [Article Type] Systematic Review
Breathing, speaking, coughing or sneezing: What drives transmission of SARS-CoV-2?Review Published on 2021-11-012023-06-19 Journal: Journal of Internal Medicine [Category] MERS, SARS, [키워드] aerosol Airborne transmission infectious dose SARS-CoV-2 speech droplet superspreading events. [DOI] 10.1111/joim.13326 PMC 바로가기 [Article Type] Review
The effectiveness of various gargle formulations and salt water against SARS-CoV-2SARS-COV-2에 대한 다양한 양치용 제제 및 바닷물의 효과Article Published on 2021-10-152022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료제, [키워드] addition Asymptomatic asymptomatic patient asymptomatic patients BSA calculated chlorhexidine chloride condition conditions COVID-19 Culture cytotoxicity disease disease spread effective Effectiveness eliminating erythrocytes European evaluated Formulation gargle Gargling hexetidine inactivation Incubation period infected patient infected patients infectious dose kill log Medical research Microbiology preventive measure preventive measures protocol reducing reduction in risk of transmission salt SAR-CoV-2 SARS-CoV-2 Spearman-Karber Spread Standard tested the disease Thymol tissue tissue culture titre titres Transmissibility Transmission Treatment Vero E6 VERO E6 cells Viral virucidal virus virus titer virus titre Virus titres virus transmission water [DOI] 10.1038/s41598-021-99866-w PMC 바로가기 [Article Type] Article
Improving human coronavirus OC43 (HCoV-OC43) research comparability in studies using HCoV-OC43 as a surrogate for SARS-CoV-2Article Published on 2021-10-092022-10-04 Journal: Journal of virological methods [Category] MERS, SARS, 치료기술, 치료제, [키워드] accompany acute respiratory syndrome added African green monkey analyzed antibodies antibody concentration approach biosafety BSL-3 Cell cell line cells Colon cancer Combination common cold comparability complicate conducted coronavirus counter CPE Culture Cytopathic effect days post infection demonstrated described droplet fibroblast Flow virometry growth Growth Curve HCoV-OC43 human coronavirus human coronavirus OC43 human lung Improving Infection infectious dose investigated kidney less multiplicity of infection pandemic parameter Plaque assay produced quantification quantified reached reducing reproducibility required Research respiratory aerosol Respiratory system Sample SARS-CoV-2 Sartorius Seven Standardization target TCID these cell tissue transmitted Vero E6 Vero E6 cell virion virus particle Virus titration [DOI] 10.1016/j.jviromet.2021.114317 PMC 바로가기 [Article Type] Article
Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset증상 발병 전 인플루엔자 및 감기를 감지하기 위해 비침습적 웨어러블 생체 모니터링 센서를 사용하는 것의 타당성 평가Research Published on 2021-09-292022-09-25 Journal: JAMA Network Open [Category] Fulltext, 신종인플루엔자, 임상, 진단, [키워드] 24 hour Accuracy age Analysis assessment AUC Can characteristic chronic respiratory Cohort cohort study Cold collected common conducted Contagion COVID-19 criteria Culture detect evaluate exposure feasibility feasible finding General population H1N1 H1N1 influenza help Human rhinovirus identify Importance individual Infection infectious dose Influenza inoculated Intervention intranasal limit measure men Mild moderate monitoring noninvasive objective Onset participant Patient Performance metrics Point Precision predict presymptomatic prevent disease spread primary outcome measure random recruited Relevance resource respiratory virus Result rhinovirus screening method sensitivity sensor Separate serum antibodies setting severity specificity Spread strain type Support Symptom symptom onset TCID50 the median tissue took place trajectory viral challenge viral infection viral respiratory infection viral respiratory infections virus [DOI] 10.1001/jamanetworkopen.2021.28534 PMC 바로가기 [Article Type] Research
Hypochlorous acid solution is a potent antiviral agent against SARS‐CoV‐2차아염소산 용액은 SARS-CoV-2에 대한 강력한 항바이러스제입니다.Original Article Published on 2021-09-172022-09-10 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity can be used caused Concentration coronavirus COVID‐19 Culture demonstrated Detection limit Diseases disinfectant evaluated expected flammable foetal bovine serum gastroenteritis HClO hypochlorous acid Impact inactivated incubated infectious dose irritation material Novel coronavirus organic matter pandemic phosphate phosphate‐buffered saline presence or absence purified reduction respiratory responsible Result Saline SARS‐CoV‐2 SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus Significance skin TCID TGEV tissue tissue culture titre Toxicity transmissible gastroenteritis virus virus virus titre was used Wuhan Wuhan, China [DOI] 10.1111/jam.15284 PMC 바로가기 [Article Type] Original Article
Evaluation of the SARS-CoV-2 Inactivation Efficacy Associated With Buffers From Three Kits Used on High-Throughput RNA Extraction PlatformsCellular and Infection Microbiology Published on 2021-09-162022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] acid addition biosafety Clinical diagnosis clinical samples Combination Culture demonstrated diagnostic Efficacy evaluated extraction guanidinium heat high throughput inactivation infectious dose isopropanol Laboratory laboratory-acquired infection lysis buffer operator PCR platform Qiagen Rapid reduced reduction Result RNA RNA extraction SARS-CoV-2 shown TCID tested the SARS-CoV-2 Thermo Fisher tissue titre Treatment viral RNA extraction Viral transport medium virus Volume VTM [DOI] 10.3389/fcimb.2021.716436 PMC 바로가기 [Article Type] Cellular and Infection Microbiology